دورية أكاديمية
A rapid review of differences in cerebrospinal neurofilament light levels in clinical subtypes of progressive multiple sclerosis.
العنوان: | A rapid review of differences in cerebrospinal neurofilament light levels in clinical subtypes of progressive multiple sclerosis. |
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المؤلفون: | Desu HL; Neuroimmunology Unit, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada., Sawicka KM; Child Health Evaluative Sciences Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada.; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Wuerch E; Hotchkiss Brain Institute and the Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada., Kitchin V; University of British Columbia Library, Vancouver, BC, Canada., Quandt JA; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
المصدر: | Frontiers in neurology [Front Neurol] 2024 Apr 09; Vol. 15, pp. 1382468. Date of Electronic Publication: 2024 Apr 09 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation, 2010]- |
مستخلص: | Background: Multiple sclerosis (MS) is divided into three clinical phenotypes: relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS). It is unknown to what extent SPMS and PPMS pathophysiology share inflammatory or neurodegenerative pathological processes. Cerebrospinal (CSF) neurofilament light (NfL) has been broadly studied in different MS phenotypes and is a candidate biomarker for comparing MS subtypes. Research Question: Are CSF NfL levels different among clinical subtypes of progressive MS? Methods: A search strategy identifying original research investigating fluid neurodegenerative biomarkers in progressive forms of MS between 2010 and 2022 was applied to Medline. Identified articles underwent title and abstract screen and full text review against pre-specified criteria. Data abstraction was limited to studies that measured NfL levels in the CSF. Reported statistical comparisons of NfL levels between clinical phenotypes were abstracted qualitatively. Results: 18 studies that focused on investigating direct comparisons of CSF NfL from people with MS were included in the final report. We found NfL levels were typically reported to be higher in relapsing and progressive MS compared to healthy controls. Notably, higher NfL levels were not clearly associated with progressive MS subtypes when compared to relapsing MS, and there was no observed difference in NfL levels between PPMS and SPMS in articles that separately assessed these phenotypes. Conclusion: CSF NfL levels distinguish individuals with MS from healthy controls but do not differentiate MS subtypes. Broad biological phenotyping is needed to overcome limitations of current clinical phenotyping and improve biomarker translatability to decision-making in the clinic. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Desu, Sawicka, Wuerch, Kitchin and Quandt.) |
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فهرسة مساهمة: | Keywords: biomarkers; multiple sclerosis; neurodegeneration; neurofilament light; progression |
تواريخ الأحداث: | Date Created: 20240424 Latest Revision: 20240426 |
رمز التحديث: | 20240426 |
مُعرف محوري في PubMed: | PMC11035744 |
DOI: | 10.3389/fneur.2024.1382468 |
PMID: | 38654736 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-2295 |
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DOI: | 10.3389/fneur.2024.1382468 |