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Advances in preclinical platforms of Loa loa for filarial neglected tropical disease drug and diagnostics research.

التفاصيل البيبلوغرافية
العنوان: Advances in preclinical platforms of Loa loa for filarial neglected tropical disease drug and diagnostics research.
المؤلفون: Wanji S; Parasite and Vector Research Unit (PAVRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation for Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon., Chunda VC; Parasite and Vector Research Unit (PAVRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation for Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon., Fombad FF; Research Foundation for Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon.; Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, Buea, Cameroon., Jélil Njouendou A; Research Foundation for Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon.; Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon., Gandjui NVT; Parasite and Vector Research Unit (PAVRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation for Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon., Ritter M; Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany., Enyong PA; Parasite and Vector Research Unit (PAVRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation for Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon., Mackenzie C; Neglected Tropical Diseases Support Center The Task Force for Global Health, 325 Swanton Way, Decatur, Atlanta, Georgia, United States of America., Taylor MJ; Centre for Drugs and Diagnostics Research and Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK., Hoerauf A; Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne partner site, Bonn, Germany., Turner JD; Centre for Drugs and Diagnostics Research and Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
المصدر: Frontiers in tropical diseases [Front Trop Dis] 2021 Nov 08; Vol. 2.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101779328 Publication Model: Print Cited Medium: Internet ISSN: 2673-7515 (Electronic) Linking ISSN: 26737515 NLM ISO Abbreviation: Front Trop Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2021]-
مستخلص: The tropical disease, loiasis, caused by the filarial parasite, Loa , has gained prominence in global public health as a cause of excess mortality and a barrier to the elimination of the related prioritized neglected tropical diseases (NTDs), lymphatic filariasis and onchocerciasis, within Central Africa. There are no effective drug cures or vaccines available to treat loiasis safely. Here we review recent advances in loiasis preclinical platform technologies, including novel in vitro culturing systems, animal models and innovations in experimental infections of the L. loa vector, Chrysops , that have facilitated access to all L. loa filarial life-cycle stages. We detail applications of these new model systems in anti-filarial drug screening, diagnostic development, immunology, and pathophysiology research. Finally, we provide an overview of how loiasis preclinical platforms may be further utilized in translational medicine applications to support the development of much needed new interventions against filarial NTDs.
Competing Interests: Conflict of Interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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معلومات مُعتمدة: EDCTP_TMA2019SFP-2814 Netherlands EDCTP_ European & Developing Countries Clinical Trials Partnership (EDCTP); NC/M00175X/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research; NC/S001131/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research
فهرسة مساهمة: Keywords: Loa; filariasis; loiasis; lymphatic filariasis; neglected tropical disease; onchocerciasis
تواريخ الأحداث: Date Created: 20240424 Latest Revision: 20240508
رمز التحديث: 20240508
مُعرف محوري في PubMed: PMC7615857
DOI: 10.3389/fitd.2021.778724
PMID: 38654889
قاعدة البيانات: MEDLINE
الوصف
تدمد:2673-7515
DOI:10.3389/fitd.2021.778724