دورية أكاديمية
Preparation of Tautomer-Pure Molecular Beams by Electrostatic Deflection.
| العنوان: | Preparation of Tautomer-Pure Molecular Beams by Electrostatic Deflection. |
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| المؤلفون: | Abma GL; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Parkes MA; Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, United Kingdom., Horke DA; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. |
| المصدر: | The journal of physical chemistry letters [J Phys Chem Lett] 2024 May 02; Vol. 15 (17), pp. 4587-4592. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7185 (Electronic) Linking ISSN: 19487185 NLM ISO Abbreviation: J Phys Chem Lett Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مستخلص: | Tautomers are ubiquitous throughout chemistry and typically considered inseparable in solution. Yet (bio)chemical activity is highly tautomer-specific, with common examples being the amino and nucleic acids. While tautomers exist in an equilibrium in solution, in the cold environment of a molecular beam the barrier to tautomerization is typically much too high for interconversion, and tautomers can be considered separate species. Here we demonstrate the first separation of tautomers within a molecular beam and the production of tautomerically pure gas-phase samples. We show this for the 2-pyridone/2-hydroxypyridine system, an important structural motif in both uracil and cytosine. Spatial separation of the tautomers is achieved via electrostatic deflection in strong inhomogeneous fields. We furthermore collect tautomer-resolved photoelectron spectra using femtosecond multiphoton ionization. This paves the way for studying the structure-function-dynamic relationship on the level of individual tautomers, using approaches that typically lack the resolution to do so, such as ultrafast dynamics experiments. |
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| تواريخ الأحداث: | Date Created: 20240424 Latest Revision: 20240508 |
| رمز التحديث: | 20240508 |
| مُعرف محوري في PubMed: | PMC11071072 |
| DOI: | 10.1021/acs.jpclett.4c00768 |
| PMID: | 38656191 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1948-7185 |
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| DOI: | 10.1021/acs.jpclett.4c00768 |