دورية أكاديمية
Adult hair follicle stem cells differentiate into neuronal cells in explanted rat intestinal tissue.
| العنوان: | Adult hair follicle stem cells differentiate into neuronal cells in explanted rat intestinal tissue. |
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| المؤلفون: | Sun Z; Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China., Huo J; Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China., Tian Y; Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China., Liu M; Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China., Liu Y; Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China., Xu M; Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China. ntxm@ntu.edu.cn., Yin Q; Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. yinqiyou@aliyun.com. |
| المصدر: | In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 2024 Jun; Vol. 60 (6), pp. 689-696. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-706X (Electronic) Linking ISSN: 10712690 NLM ISO Abbreviation: In Vitro Cell Dev Biol Anim Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Original Publication: Columbia, MD : Tissue Culture Association, c1993- |
| مواضيع طبية MeSH: | Cell Differentiation* , Rats, Sprague-Dawley* , Neurons*/cytology , Neurons*/metabolism , Hair Follicle*/cytology , Adult Stem Cells*/cytology , Adult Stem Cells*/metabolism, Animals ; Rats ; Cell Proliferation ; Intestines/cytology ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Cells, Cultured |
| مستخلص: | Hair follicle stem cells (HFSCs) are adult stem cells located in the outer root sheath of the follicle bulge with high neural plasticity, which promise a potential for the stem cell therapy for neurological diseases. Hirschsprung's disease (HD) is characterized by the absence of ganglia in the distant bowel. In this study, we elucidated the capacity of HFSCs to differentiate into neuronal cells in the aganglionic colon from embryonic rat. HFSCs were isolated from adult Sprague-Dawley (SD) rats and formed spheres that could be passaged. The cultured HFSCs expressed neural crest stem cells (NCSCs) markers such as SOX10, CD34, and nestin, which indicated their neural crest lineage. Subsequent differentiation assays demonstrated that these cells could give rise to neural progeny that expressed neuronal or glial markers. The aganglionic colon from the embryonic intestine was applied as in vitro explant to test the capacity of proliferation and differentiation of HFSCs. The HFSCs expressing GFP or RFP integrated in intestinal explants and maintained proliferative capacity. Moreover, the HFSCs differentiated into Tuj1- or S100β-positive cells in the cultured intestinal explants. The results proposed that the HFSCs might be an alternative source of neural stem cells for the HD therapy. (© 2024. The Society for In Vitro Biology.) |
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| معلومات مُعتمدة: | Z2018008 Jiangsu Commission of Health; 2015-WSW-052 Six Talent Peaks Project in Jiangsu Province |
| فهرسة مساهمة: | Keywords: Aganglionic colon; Hair follicle stem cells; Hirschsprung’s disease; Neural crest cells; Neuronal differentiation |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240729 Latest Revision: 20240729 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1007/s11626-024-00903-5 |
| PMID: | 38656569 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1543-706X |
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| DOI: | 10.1007/s11626-024-00903-5 |