دورية أكاديمية
An electroencephalogram microdisplay to visualize neuronal activity on the brain surface.
| العنوان: | An electroencephalogram microdisplay to visualize neuronal activity on the brain surface. |
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| المؤلفون: | Tchoe Y; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea., Wu T; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., U HS; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Roth DM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA., Kim D; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Lee J; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Cleary DR; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Center for the Future of Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92093, USA., Pizarro P; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Neurological Surgery, Oregon Health & Science University, Mail code CH8N, 3303 SW Bond Avenue, Portland, OR 97239, USA., Tonsfeldt KJ; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Lee K; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Chen PC; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Bourhis AM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Galton I; Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Coughlin B; Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA., Yang JC; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Neurological Surgery, Ohio State University, Columbus, OH 43210, USA., Paulk AC; Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA., Halgren E; Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92093, USA., Cash SS; Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA., Dayeh SA; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. |
| المصدر: | Science translational medicine [Sci Transl Med] 2024 Apr 24; Vol. 16 (744), pp. eadj7257. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Brain*/physiology , Electroencephalography*/methods, Animals ; Swine ; Rats ; Neurons/physiology ; Brain Mapping/methods ; Rats, Sprague-Dawley ; Electrocorticography/methods ; Male |
| مستخلص: | Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which can be time-consuming. In addition, the electrode grids that are used to measure brain activity and to identify the boundaries of pathological versus functional brain regions have low resolution and limited conformity to the brain surface. Here, we present the development of an intracranial electroencephalogram (iEEG)-microdisplay that consists of freestanding arrays of 2048 GaN light-emitting diodes laminated on the back of micro-electrocorticography electrode grids. With a series of proof-of-concept experiments in rats and pigs, we demonstrate that these iEEG-microdisplays allowed us to perform real-time iEEG recordings and display cortical activities by spatially corresponding light patterns on the surface of the brain in the surgical field. Furthermore, iEEG-microdisplays allowed us to identify and display cortical landmarks and pathological activities from rat and pig models. Using a dual-color iEEG-microdisplay, we demonstrated coregistration of the functional cortical boundaries with one color and displayed the evolution of electrical potentials associated with epileptiform activity with another color. The iEEG-microdisplay holds promise to facilitate monitoring of pathological brain activity in clinical settings. |
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| معلومات مُعتمدة: | K99 NS119291 United States NS NINDS NIH HHS; R01 NS109553 United States NS NINDS NIH HHS; UG3 NS123723 United States NS NINDS NIH HHS; R01 NS123655 United States NS NINDS NIH HHS; DP2 EB029757 United States EB NIBIB NIH HHS |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240424 Latest Revision: 20240515 |
| رمز التحديث: | 20240515 |
| مُعرف محوري في PubMed: | PMC11093107 |
| DOI: | 10.1126/scitranslmed.adj7257 |
| PMID: | 38657026 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adj7257 |