دورية أكاديمية
Thyroid and sex hormone disrupting effects of DEHTP at different life stages of zebrafish (Danio rerio).
| العنوان: | Thyroid and sex hormone disrupting effects of DEHTP at different life stages of zebrafish (Danio rerio). |
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| المؤلفون: | Ihn Y; Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address: aamike2@snu.ac.kr., Cho Y; Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address: yoojcho97@gmail.com., Lee Y; Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address: dldbfk2008@naver.com., Seok H; Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address: ssunk10040@gmail.com., Oh JS; Department of Marine Sciences and Convergence Engineering, College of Science and Convergence Technology, Hanyang University, Ansan, 15588, Republic of Korea. Electronic address: healjinsu@gmail.com., Moon HB; Department of Marine Sciences and Convergence Engineering, College of Science and Convergence Technology, Hanyang University, Ansan, 15588, Republic of Korea. Electronic address: hbmoon@hanyang.ac.kr., Choi K; Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea; Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. Electronic address: kyungho@snu.ac.kr. |
| المصدر: | Chemosphere [Chemosphere] 2024 Jun; Vol. 358, pp. 142105. Date of Electronic Publication: 2024 Apr 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Zebrafish* , Endocrine Disruptors*/toxicity , Thyroid Gland*/drug effects , Thyroid Gland*/metabolism , Thyroid Hormones*/metabolism, Animals ; Male ; Gonadal Steroid Hormones/metabolism ; Plasticizers/toxicity ; Larva/drug effects ; Water Pollutants, Chemical/toxicity ; Phthalic Acids/toxicity ; Triiodothyronine ; Diethylhexyl Phthalate/toxicity ; Diethylhexyl Phthalate/analogs & derivatives |
| مستخلص: | Di(2-ethylhexyl) terephthalate (DEHTP) is an alternative plasticizer widely used in numerous consumer products, replacing di(2-ethylhexyl) phthalate (DEHP). Hence, DEHTP has been frequently detected in the environment and humans. As a structural isomer and functional analog of DEHP, DEHTP is a suspected endocrine disruptor. Here, we evaluated thyroid-disrupting effects of DEHTP using embryo-larval and adult male zebrafish. We also investigated its sex hormone disruption potential in the adult zebrafish. After 5- and 7-days of exposure to DEHTP, significant increases in whole-body thyroid hormonal levels were observed in the larval fish. Down-regulation of several thyroid-regulating genes, including trh, tshβ, nis, and dio2, was observed, but only after 5-day exposure. Following a 21-day exposure, the adult male zebrafish exhibited a significant decrease in total triiodothyronine and an increase in thyroid-stimulating hormones. Potential changes in the deiodination of thyroid hormones, supported by the up-regulation of two deiodinases, dio1 and dio3a, along with the down-regulation of dio2, could explain the thyroid hormone changes in the adult zebrafish. Moreover, significant trends of decrease in estradiol and 11-ketotestosterone, along with increase of testosterone (T), were observed in the adult zebrafish. Up-regulation of several steroidogenic genes may explain elevated T, while exact mechanisms of action warrant further investigation. Our results demonstrate that DEHTP can cause disruptions of thyroid and sex hormones at different life stages in zebrafish. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Adult male zebrafish; Alternative plasticizer; Embryo-larva; Endocrine disruption; Terephthalate |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240521 Latest Revision: 20240521 |
| رمز التحديث: | 20240521 |
| DOI: | 10.1016/j.chemosphere.2024.142105 |
| PMID: | 38657690 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2024.142105 |