دورية أكاديمية
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Parotid hypersalivation after inferior salivatory nucleus glutamate/NMDA receptor excitation in the rat.

التفاصيل البيبلوغرافية
العنوان: Parotid hypersalivation after inferior salivatory nucleus glutamate/NMDA receptor excitation in the rat.
المؤلفون: Ramos JMJ; Department of Psychobiology and Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, Granada 18071, Spain. Electronic address: jmjramos@ugr.es.
المصدر: Physiology & behavior [Physiol Behav] 2024 Jun 01; Vol. 280, pp. 114564. Date of Electronic Publication: 2024 Apr 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
أسماء مطبوعة: Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
مواضيع طبية MeSH: N-Methylaspartate*/pharmacology , N-Methylaspartate*/metabolism , Parotid Gland*/metabolism , Parotid Gland*/drug effects , Receptors, N-Methyl-D-Aspartate*/metabolism , Salivation*/drug effects , Salivation*/physiology, Animals ; Male ; Rats ; Adrenergic beta-Antagonists/pharmacology ; Atropine/pharmacology ; Excitatory Amino Acid Agonists/pharmacology ; Medulla Oblongata/metabolism ; Medulla Oblongata/drug effects ; Microinjections ; Propranolol/pharmacology ; Rats, Wistar ; Saliva/metabolism ; Sialorrhea
مستخلص: Although salivation is essential during eating behavior, little is known about the brainstem centers that directly control the salivary glands. With regard to the inferior salivatory nucleus (ISN), the site of origin of the parasympathetic preganglionic cell bodies that innervate the parotid glands, previous anatomical studies have located it within the rostrodorsal medullary reticular formation. However, to date there is no functional data that shows the secretory nature of the somas grouped in this region. To activate only the somas and rule out the activation of the efferent fibers from and the afferent fibers to the ISN, in exp. 1, NMDA neurotoxin was administered to the rostrodorsal medullary region and the secretion of saliva was recorded during the following hour. Results showed an increased secretion of parotid saliva but a total absence of submandibular-sublingual secretion. In exp. 2, results showed that the hypersecretion of parotid saliva after NMDA microinjection was completely blocked by the administration of atropine (a cholinergic blocker) but not after administration of dihydroergotamine plus propranolol (α and β-adrenergic blockers, respectively). These findings suggest that the somata of the rostrodorsal medulla are secretory in nature, controlling parotid secretion via a cholinergic pathway. The data thus functionally supports the idea that these cells constitute the ISN.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Inferior salivatory nucleus; Parotid; Saliva; Salivary glands; Salivation
المشرفين على المادة: 0 (Adrenergic beta-Antagonists)
7C0697DR9I (Atropine)
0 (Excitatory Amino Acid Agonists)
6384-92-5 (N-Methylaspartate)
9Y8NXQ24VQ (Propranolol)
0 (Receptors, N-Methyl-D-Aspartate)
تواريخ الأحداث: Date Created: 20240424 Date Completed: 20240505 Latest Revision: 20240530
رمز التحديث: 20240531
DOI: 10.1016/j.physbeh.2024.114564
PMID: 38657747
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-507X
DOI:10.1016/j.physbeh.2024.114564