دورية أكاديمية
The role of DNA and RNA guanosine oxidation in cardiovascular diseases.
| العنوان: | The role of DNA and RNA guanosine oxidation in cardiovascular diseases. |
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| المؤلفون: | Li Y; Cardiovascular Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Cardiovascular Research Institute of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai 201203, China., Wang X; Cardiovascular Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Cardiovascular Research Institute of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai 201203, China. Electronic address: wxlqy0214@163.com. |
| المصدر: | Pharmacological research [Pharmacol Res] 2024 Jun; Vol. 204, pp. 107187. Date of Electronic Publication: 2024 Apr 23. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : Amsterdam ; Elsevier Original Publication: London ; San Diego : Academic Press, c1989- |
| مواضيع طبية MeSH: | Cardiovascular Diseases*/metabolism , Cardiovascular Diseases*/genetics , RNA*/metabolism , RNA*/genetics , Oxidation-Reduction* , Guanosine*/analogs & derivatives , Guanosine*/metabolism , DNA*/metabolism , Oxidative Stress* , Guanine*/analogs & derivatives , Guanine*/metabolism, Humans ; Animals ; DNA Damage |
| مستخلص: | Cardiovascular diseases (CVD) persist as a prominent cause of mortality worldwide, with oxidative stress constituting a pivotal contributory element. The oxidative modification of guanosine, specifically 8-oxoguanine, has emerged as a crucial biomarker for oxidative stress, providing novel insights into the molecular underpinnings of CVD. 8-Oxoguanine can be directly generated at the DNA (8-oxo-dG) and RNA (8-oxo-G) levels, as well as at the free nucleotide level (8-oxo-dGTP or 8-oxo-GTP), which are produced and can be integrated through DNA replication or RNA transcription. When exposed to oxidative stress, guanine is more readily produced in RNA than in DNA. A burgeoning body of research surrounds 8-oxoguanine, exhibits its accumulation playing a pivotal role in the development of CVD. Therapeutic approaches targeting oxidative 8-Oxoguanine damage to DNA and RNA, encompassing the modulation of repair enzymes and the development of small molecule inhibitors, are anticipated to enhance CVD management. In conclusion, we explore the noteworthy elevation of 8-oxoguanine levels in patients with various cardiac conditions and deliberate upon the formation and regulation of 8-oxo-dG and 8-oxo-G under oxidative stress, as well as their function in CVD. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 8-hydroxy-2-deoxyguanosine; 8-oxo-guanosine; Cardiovascular diseases; Guanosine oxidation |
| المشرفين على المادة: | 63231-63-0 (RNA) 12133JR80S (Guanosine) 9007-49-2 (DNA) 5614-64-2 (8-hydroxyguanine) 5Z93L87A1R (Guanine) |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240530 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| DOI: | 10.1016/j.phrs.2024.107187 |
| PMID: | 38657843 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-1186 |
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| DOI: | 10.1016/j.phrs.2024.107187 |