دورية أكاديمية
The transgenerational effects of maternal low-protein diet during lactation on offspring.
| العنوان: | The transgenerational effects of maternal low-protein diet during lactation on offspring. |
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| المؤلفون: | Gu LJ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China., Li L; Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing 100021, China., Li QN; Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, China., Xu K; Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, China., Yue W; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China., Qiao JY; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China., Meng TG; Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, China., Dong MZ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China., Lei WL; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China., Guo JN; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China., Wang ZB; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China., Sun QY; Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, China. Electronic address: sunqy@gd2h.org.cn. |
| المصدر: | Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Apr 23. Date of Electronic Publication: 2024 Apr 23. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Orlando, FL : Science press ; Elsevier |
| مستخلص: | Environmental factors such as diet and lifestyle can influence the health of both mothers and offspring. However, its transgenerational transmission and underlying mechanisms remain largely unknown. Here, using a maternal lactation-period low-protein diet (LPD) mouse model, we show that maternal LPD during lactation causes decreased survival and stunted growth, significantly reduces ovulation and litter size, and alters the gut microbiome in the female LPD-F1 offspring. The transcriptome of LPD-F1 metaphase II (MII) oocytes shows that differentially expressed genes are enriched in female pregnancy and multiple metabolic processes. Moreover, maternal LPD causes early stunted growth and impairs metabolic health, which is transmitted over two generations. The methylome alteration of LPD-F1 oocytes can be partly transmitted to the F2 oocytes. Together, our results reveal that LPD during lactation transgenerationally affects offspring health, probably via oocyte epigenetic changes. Competing Interests: Conflict of interest All authors declare no conflict of competing interest. (Copyright © 2024 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: DNA methylation; Lactation diet; Maternal low-protein diet; Oocyte; Transgenerational effect |
| تواريخ الأحداث: | Date Created: 20240424 Latest Revision: 20240516 |
| رمز التحديث: | 20240517 |
| DOI: | 10.1016/j.jgg.2024.04.008 |
| PMID: | 38657948 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1673-8527 |
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| DOI: | 10.1016/j.jgg.2024.04.008 |