دورية أكاديمية
Impact of methimazole-induced hypothyroidism on postnatal swine.
| العنوان: | Impact of methimazole-induced hypothyroidism on postnatal swine. |
|---|---|
| المؤلفون: | Fazioli JC; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA., Mulligan MK; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA., Ison EK; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA., Pasternak JA; Department of Animal Science, Purdue University, West Lafayette, Indiana, USA. |
| المصدر: | Physiological reports [Physiol Rep] 2024 Apr; Vol. 12 (8), pp. e16007. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
| مواضيع طبية MeSH: | Methimazole*/toxicity , Methimazole*/adverse effects , Hypothyroidism*/chemically induced , Hypothyroidism*/metabolism , Antithyroid Agents*/toxicity , Antithyroid Agents*/adverse effects , Thyroid Gland*/drug effects , Thyroid Gland*/metabolism , Thyroid Gland*/pathology, Animals ; Swine ; Female ; Triiodothyronine/blood ; Liver/metabolism ; Liver/drug effects ; Liver/pathology ; Thyroxine/blood ; Male |
| مستخلص: | Thyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response to disease or environmental conditions, but the physiological impact of such disruption has not been established. The objective of this study was to evaluate the impact of hypothyroidism induced with the antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for the duration of treatment but had only a transient effect on circulating thyroxine (T4). Thyroid tissue weight was significantly increased by more than 3.5-fold in response to MMI treatment. Histologically, the eosinophilic colloid was largely absent from the thyroid follicle which displayed a disorganized columnar epithelium consistent with goiter. MMI induced hypothyroidism has no effect on growth rate over 28 days. Hepatic expression of genes associated with thyroid metabolism (DIO1, DIO2, and DIO3), lipid utilization (CD36, FASN, and ACACA), apoptosis (TP53, PERP, SIVA1, and SFN) and proliferation (CDK1, CDK2, CDK4, and CDKN1A) were unaffected by treatment. Collectively these results demonstrate that MMI induces mild systemic hypothyroidism and pronounced goiter, indicating a strong homeostatic central regulation within the hypothalamic pituitary thyroid axis. This combined with limited peripheral effects, indicates resilience to hypothyroidism in modern swine. (© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
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| فهرسة مساهمة: | Keywords: goiter; hypothyroidism; methimazole; swine; thyroid Axis regulation |
| المشرفين على المادة: | 554Z48XN5E (Methimazole) 0 (Antithyroid Agents) 06LU7C9H1V (Triiodothyronine) Q51BO43MG4 (Thyroxine) |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240425 Latest Revision: 20240427 |
| رمز التحديث: | 20240427 |
| مُعرف محوري في PubMed: | PMC11043046 |
| DOI: | 10.14814/phy2.16007 |
| PMID: | 38658325 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2051-817X |
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| DOI: | 10.14814/phy2.16007 |