دورية أكاديمية
Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer.
العنوان: | Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer. |
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المؤلفون: | Lee SY; Department of Surgery, Inha University Hospital, Incheon, Korea., Yoo TK; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Kim J; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Chung IY; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Ko BS; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Kim HJ; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Lee JW; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Son BH; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Lee SB; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea. newstar153@hanmail.net. |
المصدر: | Breast cancer research and treatment [Breast Cancer Res Treat] 2024 Aug; Vol. 206 (3), pp. 495-507. Date of Electronic Publication: 2024 Apr 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981- |
مواضيع طبية MeSH: | Breast Neoplasms*/pathology , Breast Neoplasms*/surgery , Lymphatic Metastasis*/pathology , Axilla* , Sentinel Lymph Node Biopsy* , Lymph Nodes*/pathology , Lymph Nodes*/surgery, Humans ; Female ; Middle Aged ; Retrospective Studies ; Risk Factors ; Adult ; Aged ; Lymph Node Excision ; Neoplasm Invasiveness ; Mastectomy ; Aged, 80 and over |
مستخلص: | Purpose: To select patients who would benefit most from sentinel lymph node biopsy (SLNB) by investigating the characteristics and risk factors of axillary lymph node metastasis (ALNM) in microinvasive breast cancer (MIBC). Methods: This retrospective study included 1688 patients with MIBC who underwent breast surgery with axillary staging at the Asan Medical Center from 1995 to 2020. Results: Most patients underwent SLNB alone (83.5%). Seventy (4.1%) patients were node-positive, and the majority had positive lymph nodes < 10 mm, with micro-metastases occurring frequently (n = 37; 55%). Node-positive patients underwent total mastectomy and axillary lymph node dissection (ALND) more than breast-conserving surgery (BCS) and SLNB compared with node-negative patients (p < 0.001). In the multivariate analysis, independent predictors of ALNM included young age [odds ratio (OR) 0.959; 95% confidence interval (CI) 0.927-0.993; p = 0.019], ALND (OR 11.486; 95% CI 5.767-22.877; p < 0.001), number of lymph nodes harvested (≥ 5) (OR 3.184; 95% CI 1.555-6.522; p < 0.001), lymphovascular invasion (OR 6.831; 95% CI 2.386-19.557; p < 0.001), presence of multiple microinvasion foci (OR 2.771; 95% CI 1.329-5.779; p = 0.007), prominent lymph nodes in preoperative imaging (OR 2.675; 95% CI 1.362-5.253; p = 0.004), and hormone receptor positivity (OR 2.491; 95% CI 1.230-5.046; p = 0.011). Conclusion: Low ALNM rate (4.1%) suggests that routine SLNB for patients with MIBC is unnecessary but can be valuable for patients with specific risk factors. Ongoing trials for omitting SLNB in early breast cancer, and further subanalyses focusing on rare populations with MIBC are necessary. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
References: | Prasad ML, Osborne MP, Giri DD, Hoda SA (2000) Microinvasive carcinoma (T1mic) of the breast: clinicopathologic profile of 21 cases. Am J Surg Pathol 24(3):422–428. https://doi.org/10.1097/00000478-200003000-00012. (PMID: 10.1097/00000478-200003000-0001210716157) Shatat L, Gloyeske N, Madan R, O’Neil M, Tawfik O, Fan F (2013) Microinvasive breast carcinoma carries an excellent prognosis regardless of the tumor characteristics. Hum Pathol 44(12):2684–2689. https://doi.org/10.1016/j.humpath.2013.07.010. (PMID: 10.1016/j.humpath.2013.07.01024071019) Costarelli L, Cianchetti E, Corsi F, Friedman D, Ghilli M, Lacaria M, Menghini L, Murgo R, Ponti A, Rinaldi S, Del Turco MR, Taffurelli M, Tinterri C, Tomatis M, Fortunato L (2019) Microinvasive breast carcinoma: an analysis from ten Senonetwork Italia breast centres. Eur J Surg Oncol 45(2):147–152. https://doi.org/10.1016/j.ejso.2018.09.024. (PMID: 10.1016/j.ejso.2018.09.02430482543) Giuliano AE, Hunt KK, Ballman KV et al (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305(6):569–575. https://doi.org/10.1001/jama.2011.90. (PMID: 10.1001/jama.2011.90213040825389857) Verreck EEF, van Steenhoven JEC, Kuijer A et al (2023) Trends of axillary treatment in sentinel node-positive breast cancer patients undergoing mastectomy. Ann Surg Oncol. https://doi.org/10.1245/s10434-023-13568-3. (PMID: 10.1245/s10434-023-13568-33737884510409668) Poodt IG, Spronk PE, Vugts G, van Dalen T, Peeters MV, Rots ML, Schipper RJ et al (2018) Trends on axillary surgery in nondistant metastatic breast cancer patients treated between 2011 and 2015: a Dutch population-based study in the ACOSOG-Z0011 and AMAROS era. Ann Surg 268(6):1084–1090. (PMID: 10.1097/SLA.000000000000244028742702) The Breast, Vol.68, Suppl.1-April 2023 https://breast-ibcc-2023.elsevierdigitaledition.com/ Accessed 1 June 2023. Choi B, Jegatheeswaran L, Nakhoul M, Haria P, Srivastava R, Karki S, Babu E et al (2021) Axillary staging in ductal carcinoma in situ with microinvasion: a meta-analysis. Surg Oncol 37:101557. (PMID: 10.1016/j.suronc.2021.10155733819852) Magnoni F, Massari G, Santomauro G, Bagnardi V, Pagan E, Peruzzotti G, Sacchini VS et al (2019) Sentinel lymph node biopsy in microinvasive ductal carcinoma in situ. J Br Surg 106(4):375–383. (PMID: 10.1002/bjs.11079) Guth AA, Mercado C, Roses DF, Darvishian F, Singh B, Cangiarella JF (2008) Microinvasive breast cancer and the role of sentinel node biopsy: an institutional experience and review of the literature. Breast J 14(4):335–339. https://doi.org/10.1111/j.1524-4741.2008.00594.x. (PMID: 10.1111/j.1524-4741.2008.00594.x18537917) Holm-Rasmussen EV, Jensen MB, Balslev E, Kroman N, Tvedskov TF (2019) Sentinel and non-sentinel lymph node metastases in patients with microinvasive breast cancer: a nationwide study. Breast Cancer Res Treat 175:713–719. (PMID: 10.1007/s10549-019-05200-430877405) Paik PS, Paik NS, Lee ES, Choi JE, Jeong J, Youn HJ, Yoo TK et al (2022) Low incidence of lymph node metastasis in patients with microinvasive breast cancer: a Korean nationwide study. Ann Surg Treat Res 102(6):306–312. (PMID: 10.4174/astr.2022.102.6.306358009989204023) Ambrosini-Spaltro A, Di Donato F, Saragoni L, Cserni G, Rakha E, Foschini MP (2023) Prognostic markers of microinvasive breast carcinoma: a systematic review and meta-analysis. Cancers 15(11):3007. https://doi.org/10.3390/cancers15113007. (PMID: 10.3390/cancers151130073729696810252130) Chen J, Luo B, Gao M, Cai G, Luo X, Zhang-Cai Y, Chen Y (2022) Regional lymph node metastasis and axillary surgery of microinvasive breast cancer: a population-based study. Diagnostics 12(5):1049. (PMID: 10.3390/diagnostics12051049356262059139994) Phantana-Angkool A, Voci AE, Warren YE, Livasy CA, Beasley LM, Robinson MM, White RL et al (2019) Ductal carcinoma in situ with microinvasion on core biopsy: evaluating tumor upstaging rate, lymph node metastasis rate, and associated predictive variables. Ann Surg Oncol 26:3874–3882. (PMID: 10.1245/s10434-019-07604-431342378) Flanagan MR, Stempel M, Brogi E, Morrow M, Cody HS (2019) Is sentinel lymph node biopsy required for a core biopsy diagnosis of ductal carcinoma in situ with microinvasion? Ann Surg Oncol 26:2738–2746. (PMID: 10.1245/s10434-019-07475-9311479956684408) Ko BS, Lim WS, Kim HJ, Yu JH, Lee JW, Kwan SB, Ahn SH et al (2012) Risk factor for axillary lymph node metastases in microinvasive breast cancer. Ann Surg Oncol 19:212–216. (PMID: 10.1245/s10434-011-1812-221633867) Kapoor NS, Shamonki J, Sim MS, Chung CT, Giuliano AE (2013) Impact of multifocality and lymph node metastasis on the prognosis and management of microinvasive breast cancer. Ann Surg Oncol 20:2576–2581. (PMID: 10.1245/s10434-013-2924-723468047) Hacking SM, Leonard KL, Wu D et al (2022) Microinvasive breast cancer and the role of sentinel lymph node biopsy. Sci Rep 12:12391. https://doi.org/10.1038/s41598-022-16521-8. (PMID: 10.1038/s41598-022-16521-8358589709300703) Orzalesi L, Casella D, Criscenti V, Gjondedaj U, Bianchi S, Vezzosi V, Nori J, Cecconi L, Meattini I, Livi L, Bernini M (2016) Microinvasive breast cancer: pathological parameters, cancer subtypes distribution, and correlation with axillary lymph nodes invasion: results of a large single-institution series. Breast cancer (Tokyo, Jpn) 23(4):640–648. https://doi.org/10.1007/s12282-015-0616-9. (PMID: 10.1007/s12282-015-0616-9) Matsen CB, Hirsch A, Eaton A, Stempel M, Heerdt A, Van Zee KJ, Cody HS 3rd, Morrow M, Plitas G (2014) Extent of microinvasion in ductal carcinoma in situ is not associated with sentinel lymph node metastases. Ann Surg Oncol 21(10):3330–3335. https://doi.org/10.1245/s10434-014-3920-2. (PMID: 10.1245/s10434-014-3920-2250921604389284) Pimiento JM, Lee MC, Esposito NN, Kiluk JV, Khakpour N, Carter WB, Han G, Laronga C (2011) Role of axillary staging in women diagnosed with ductal carcinoma in situ with microinvasion. J Oncol Practe 7(5):309–313. (PMID: 10.1200/JOP.2010.000096) Wang W, Zhu W, Du F, Luo Y, Xu B (2017) The demographic features, clinicopathological characteristics and cancer-specific outcomes for patients with microinvasive breast cancer: a SEER database analysis. Sci Rep 7(1):42045. (PMID: 10.1038/srep42045281650145292735) Chen C, Huang S, Huang A, Jia Y, Wang J, Zhang Z, Mao M, Wang L, Zhou J (2018) Risk factors for lymph node metastasis and the impact of adjuvant chemotherapy on ductal carcinoma in situ with microinvasion: a population-based study. OncoTargets therapy 18:9071–9080. (PMID: 10.2147/OTT.S186228) Lyons JM 3rd, Stempel M, Van Zee KJ, Cody HS 3rd (2012) Axillary node staging for microinvasive breast cancer: is it justified? Ann Surg Oncol 19(11):3416–3421. https://doi.org/10.1245/s10434-012-2376-5. (PMID: 10.1245/s10434-012-2376-522576061) Gooch JC, Schnabel F, Chun J, Pirraglia E, Troxel AB, Guth A, Shapiro R, Axelrod D, Roses D (2019) A nomogram to predict factors associated with lymph node metastasis in ductal carcinoma in situ with microinvasion. Ann Surg Oncol 26(13):4302–4309. https://doi.org/10.1245/s10434-019-07750-. (PMID: 10.1245/s10434-019-07750-31529311) Daidone MG, Coradini D, Martelli G, Veneroni S (2003) Primary breast cancer in elderly women: biological profile and relation with clinical outcome. Crit Rev Oncol Hematol 45(3):313–325. (PMID: 10.1016/S1040-8428(02)00144-012633842) Wildiers H, Van Calster B, van de Poll-Franse LV, Hendrickx W, Røislien J, Smeets A et al (2009) Relationship between age and axillary lymph node involvement in women with breast cancer. J Clin Oncol 27(18):2931–2937. (PMID: 10.1200/JCO.2008.16.761919451448) Han, W., Kang, S. Y., & Korean Breast Cancer Society (2010) Relationship between age at diagnosis and outcome of premenopausal breast cancer: age less than 35 years is a reasonable cut-off for defining young age-onset breast cancer. Breast Cancer Res Treat 119(1):193–200. https://doi.org/10.1007/s10549-009-0388-z. (PMID: 10.1007/s10549-009-0388-z19350387) Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM (2020) Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study. Lancet Glob Health 8(8):e1027–e1037. https://doi.org/10.1016/S2214-109X(20)30215-1. (PMID: 10.1016/S2214-109X(20)30215-132710860) Society of Surgical Oncology: Choosing Wisely (2016) https://www.choosingwisely.org/clinician-lists/sso-sentinel-node-biopsy-in-node-negative-women-70-and-over/ . Accessed 20 Nov 2022. Dihge L, Bendahl PO, Rydén L (2017) Nomograms for preoperative prediction of axillary nodal status in breast cancer. J Br Surg 104(11):1494–1505. (PMID: 10.1002/bjs.10583) Luo N, Wen Y, Zou Q et al (2022) Construction and validation of a risk prediction model for clinical axillary lymph node metastasis in T1–2 breast cancer. Sci Rep 12:687. https://doi.org/10.1038/s41598-021-04495-y. (PMID: 10.1038/s41598-021-04495-y350275888758717) Wang Q, Li B, Liu Z et al (2022) Prediction model of axillary lymph node status using automated breast ultrasound (ABUS) and ki-67 status in early-stage breast cancer. BMC Cancer 22:929. https://doi.org/10.1186/s12885-022-10034-3. (PMID: 10.1186/s12885-022-10034-3360316029420256) Liu Y, Ye F, Wang Y, Zheng X, Huang Y, Zhou J (2022) Elaboration and validation of a nomogram based on axillary ultrasound and tumor clinicopathological features to predict axillary lymph node metastasis in patients with breast cancer. Front Oncol 12:845334. (PMID: 10.3389/fonc.2022.845334356517969148964) |
معلومات مُعتمدة: | 2017-1341 Asan Institute for Life Sciences, Asan Medical Center |
فهرسة مساهمة: | Keywords: Axillary lymph node metastasis; Lymphovascular invasion; Microinvasive breast cancer; Sentinel lymph node biopsy |
تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240626 Latest Revision: 20240626 |
رمز التحديث: | 20240626 |
DOI: | 10.1007/s10549-024-07305-x |
PMID: | 38658448 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7217 |
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DOI: | 10.1007/s10549-024-07305-x |