Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer.

التفاصيل البيبلوغرافية
العنوان:	Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer.
المؤلفون:	Lee SY; Department of Surgery, Inha University Hospital, Incheon, Korea., Yoo TK; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Kim J; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Chung IY; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Ko BS; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Kim HJ; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Lee JW; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Son BH; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea., Lee SB; Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea. newstar153@hanmail.net.
المصدر:	Breast cancer research and treatment [Breast Cancer Res Treat] 2024 Aug; Vol. 206 (3), pp. 495-507. Date of Electronic Publication: 2024 Apr 25.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE
أسماء مطبوعة:	Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981-
مواضيع طبية MeSH:	Breast Neoplasms/pathology , Breast Neoplasms/surgery , Lymphatic Metastasis/pathology , Axilla , Sentinel Lymph Node Biopsy* , Lymph Nodes/pathology , Lymph Nodes/surgery, Humans ; Female ; Middle Aged ; Retrospective Studies ; Risk Factors ; Adult ; Aged ; Lymph Node Excision ; Neoplasm Invasiveness ; Mastectomy ; Aged, 80 and over
مستخلص:	Purpose: To select patients who would benefit most from sentinel lymph node biopsy (SLNB) by investigating the characteristics and risk factors of axillary lymph node metastasis (ALNM) in microinvasive breast cancer (MIBC). Methods: This retrospective study included 1688 patients with MIBC who underwent breast surgery with axillary staging at the Asan Medical Center from 1995 to 2020. Results: Most patients underwent SLNB alone (83.5%). Seventy (4.1%) patients were node-positive, and the majority had positive lymph nodes < 10 mm, with micro-metastases occurring frequently (n = 37; 55%). Node-positive patients underwent total mastectomy and axillary lymph node dissection (ALND) more than breast-conserving surgery (BCS) and SLNB compared with node-negative patients (p < 0.001). In the multivariate analysis, independent predictors of ALNM included young age [odds ratio (OR) 0.959; 95% confidence interval (CI) 0.927-0.993; p = 0.019], ALND (OR 11.486; 95% CI 5.767-22.877; p < 0.001), number of lymph nodes harvested (≥ 5) (OR 3.184; 95% CI 1.555-6.522; p < 0.001), lymphovascular invasion (OR 6.831; 95% CI 2.386-19.557; p < 0.001), presence of multiple microinvasion foci (OR 2.771; 95% CI 1.329-5.779; p = 0.007), prominent lymph nodes in preoperative imaging (OR 2.675; 95% CI 1.362-5.253; p = 0.004), and hormone receptor positivity (OR 2.491; 95% CI 1.230-5.046; p = 0.011). Conclusion: Low ALNM rate (4.1%) suggests that routine SLNB for patients with MIBC is unnecessary but can be valuable for patients with specific risk factors. Ongoing trials for omitting SLNB in early breast cancer, and further subanalyses focusing on rare populations with MIBC are necessary. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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معلومات مُعتمدة:	2017-1341 Asan Institute for Life Sciences, Asan Medical Center
فهرسة مساهمة:	Keywords: Axillary lymph node metastasis; Lymphovascular invasion; Microinvasive breast cancer; Sentinel lymph node biopsy
تواريخ الأحداث:	Date Created: 20240424 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث:	20240626
DOI:	10.1007/s10549-024-07305-x
PMID:	38658448
قاعدة البيانات:	MEDLINE

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تدمد:	1573-7217
DOI:	10.1007/s10549-024-07305-x