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Contribution of systemic factors on macular vessel density: a sex-specific population-based study.

التفاصيل البيبلوغرافية
العنوان: Contribution of systemic factors on macular vessel density: a sex-specific population-based study.
المؤلفون: Chan WCF; LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Zhu MM; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Choy BNK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China. bonniechoynk@gmail.com., Chan JCH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Ng ALK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Shih KC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Cheung JJC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Wong JKW; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Shum JWH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Ni MY; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China.; Healthy High Density Cities Laboratory, HKUrbanLab, The University of Hong Kong, Hong Kong SAR, China., Lai JSM; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China., Leung GM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Wong IYH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Hong Kong SAR, China.; Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China.
المصدر: Japanese journal of ophthalmology [Jpn J Ophthalmol] 2024 May; Vol. 68 (3), pp. 174-182. Date of Electronic Publication: 2024 Apr 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Tokyo Country of Publication: Japan NLM ID: 0044652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-2246 (Electronic) Linking ISSN: 00215155 NLM ISO Abbreviation: Jpn J Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2004- : Tokyo : Springer Tokyo
Original Publication: Tokyo, Dept. of Ophthalmology, School of Medicine, Univ. of Tokyo.
مواضيع طبية MeSH: Tomography, Optical Coherence*/methods , Retinal Vessels*/diagnostic imaging , Fluorescein Angiography*/methods , Macula Lutea*/blood supply , Macula Lutea*/diagnostic imaging, Humans ; Male ; Cross-Sectional Studies ; Female ; Middle Aged ; Sex Factors ; Fundus Oculi ; Aged ; Adult ; Risk Factors ; Body Mass Index ; Microvascular Density ; Population Surveillance ; Retrospective Studies
مستخلص: Purpose: To evaluate the influence of systemic factors on macular vessel density in quantitative Optical Coherence Tomography Angiography (OCTA) by sex.
Study Design: A cross-sectional study.
Methods: A total of 2018 adults were recruited in this study. Participants were excluded (n=964) due to missing data, eye-related problems, or low OCTA scan quality. Macular vessel densities were measured with OCTA using split-spectrum amplitude decorrelation angiography algorithm. Only the data from the right eyes were selected for analysis. Multivariable linear regression analysis was performed to determine the associations between macular vessel density and obesity-related systemic factors in each gender group.
Results: The right eyes of 1054 participants (59.6% women) were enrolled. Men had significantly higher obesity parameters and associated risk factors. In multivariable linear regression analysis in men, older age and type 2 diabetes mellitus were independently associated with lower superficial retinal vessel density (β = -0.37, p = 0.002; β = -1.22, p = 0.03) and deep retinal vessel density, respectively (β = -0.66, p < 0.001; β = -1.76, p = 0.02); positive association was also observed between body mass index (BMI) and superficial retinal vessel density (β = 0.56, p = 0.02). In women, only higher systolic blood pressure was independently associated with a lower deep retinal vessel density (β = -0.50, p = 0.003).
Conclusions: This large cross-sectional study shows that older age and type 2 diabetes mellitus are associated with lower superficial and deep retinal capillary vessel density in men. This may help clinicians better understand how systemic factors influence retinal vessel density in different genders and future studies can ascertain more potential sex differences.
(© 2024. Japanese Ophthalmological Society.)
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فهرسة مساهمة: Keywords: Macular microcirculation; OCTA; Obesity; Vessel density
تواريخ الأحداث: Date Created: 20240424 Date Completed: 20240510 Latest Revision: 20240510
رمز التحديث: 20240510
DOI: 10.1007/s10384-024-01053-7
PMID: 38658452
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-2246
DOI:10.1007/s10384-024-01053-7