دورية أكاديمية
Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection.
العنوان: | Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection. |
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المؤلفون: | Yousfi FZE; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Haroun AE; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Nebhani C; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Belayachi J; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco., Askander O; Faculty of Medical Science, Mohammed VI Polytechnic University, Benguerir, Morocco., Fahime EE; Molecular Biology and Functional Genomics Platform, National Center for Scientific and Technical Research, Rabat, Morocco., Fares H; Intensive Care Department, Cheikh Zaid International Universitary Hospital, Rabat, Morocco., Ennibi K; Virology, Infectious and Tropical Diseases Center, Hopital Militaire d'Instruction Mohammed V, Rabat, Morocco., Abouqal R; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Razine R; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Bouhouche A; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco. a.bouhouche@um5r.ac.ma.; Genomic Center of the Cheikh Zaid Foundation, Abulcasis International University of Health Sciences, Rabat, Morocco. a.bouhouche@um5r.ac.ma. |
المصدر: | Archives of virology [Arch Virol] 2024 Apr 25; Vol. 169 (5), pp. 109. Date of Electronic Publication: 2024 Apr 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Wien, New York, Springer-Verlag. |
مواضيع طبية MeSH: | 2',5'-Oligoadenylate Synthetase*/genetics , COVID-19*/genetics , COVID-19*/virology , COVID-19*/epidemiology , Polymorphism, Single Nucleotide*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Africa, Northern ; Alleles ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; North African People ; Prevalence |
مستخلص: | The clinical presentation of COVID-19 shows high variability among individuals, which is partly due to genetic factors. The OAS1/2/3 cluster has been found to be strongly associated with COVID-19 severity. We examined this locus in the Moroccan population for the occurrence of the critical variant rs10774671 and its respective haplotype blocks. The frequency of single-nucleotide polymorphisms (SNPs) in the cluster of OAS immunity genes in 157 unrelated individuals of Moroccan origin was determined using an in-house exome database. OAS1 exon 6 of 71 SARS-CoV-2-positive individuals with asymptomatic/mild disease and 74 with moderate/severe disease was sequenced by the Sanger method. The genotypic, allelic, and haplotype frequencies of three SNPs were compared between these two groups. Finally, males in our COVID-19 series were genotyped for the Berber-specific marker E-M81. The prevalence of the OAS1 rs10774671-G allele in present-day Moroccans was found to be 40.4%, which is similar to that found in Europeans. However, it was found equally in both the Neanderthal GGG haplotype and the African GAC haplotype, with a frequency of 20% each. These two haplotypes, and hence the rs10774671-G allele, were significantly associated with protection against severe COVID-19 (p = 0.034, p = 0.041, and p = 0.008, respectively). Surprisingly, in men with the Berber-specific uniparental markers, the African haplotype was absent, while the prevalence of the Neanderthal haplotype was similar to that in Europeans. The protective rs10774671-G allele of OAS1 was found only in the Neanderthal haplotype in Berbers, the indigenous people of North Africa, suggesting that this region may have served as a stepping-stone for the passage of hominids to other continents. (© 2024. The Author(s).) |
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المشرفين على المادة: | EC 2.7.7.84 (2',5'-Oligoadenylate Synthetase) EC 2.7.7.- (OAS1 protein, human) |
تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240425 Latest Revision: 20240523 |
رمز التحديث: | 20240523 |
مُعرف محوري في PubMed: | PMC11043147 |
DOI: | 10.1007/s00705-024-06038-y |
PMID: | 38658463 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-8798 |
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DOI: | 10.1007/s00705-024-06038-y |