Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection.

التفاصيل البيبلوغرافية
العنوان:	Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection.
المؤلفون:	Yousfi FZE; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Haroun AE; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Nebhani C; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Belayachi J; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco., Askander O; Faculty of Medical Science, Mohammed VI Polytechnic University, Benguerir, Morocco., Fahime EE; Molecular Biology and Functional Genomics Platform, National Center for Scientific and Technical Research, Rabat, Morocco., Fares H; Intensive Care Department, Cheikh Zaid International Universitary Hospital, Rabat, Morocco., Ennibi K; Virology, Infectious and Tropical Diseases Center, Hopital Militaire d'Instruction Mohammed V, Rabat, Morocco., Abouqal R; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Razine R; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Bouhouche A; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco. a.bouhouche@um5r.ac.ma.; Genomic Center of the Cheikh Zaid Foundation, Abulcasis International University of Health Sciences, Rabat, Morocco. a.bouhouche@um5r.ac.ma.
المصدر:	Archives of virology [Arch Virol] 2024 Apr 25; Vol. 169 (5), pp. 109. Date of Electronic Publication: 2024 Apr 25.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Wien, New York, Springer-Verlag.
مواضيع طبية MeSH:	2',5'-Oligoadenylate Synthetase/genetics , COVID-19/genetics , COVID-19/virology , COVID-19/epidemiology , Polymorphism, Single Nucleotide*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Africa, Northern ; Alleles ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; North African People ; Prevalence
مستخلص:	The clinical presentation of COVID-19 shows high variability among individuals, which is partly due to genetic factors. The OAS1/2/3 cluster has been found to be strongly associated with COVID-19 severity. We examined this locus in the Moroccan population for the occurrence of the critical variant rs10774671 and its respective haplotype blocks. The frequency of single-nucleotide polymorphisms (SNPs) in the cluster of OAS immunity genes in 157 unrelated individuals of Moroccan origin was determined using an in-house exome database. OAS1 exon 6 of 71 SARS-CoV-2-positive individuals with asymptomatic/mild disease and 74 with moderate/severe disease was sequenced by the Sanger method. The genotypic, allelic, and haplotype frequencies of three SNPs were compared between these two groups. Finally, males in our COVID-19 series were genotyped for the Berber-specific marker E-M81. The prevalence of the OAS1 rs10774671-G allele in present-day Moroccans was found to be 40.4%, which is similar to that found in Europeans. However, it was found equally in both the Neanderthal GGG haplotype and the African GAC haplotype, with a frequency of 20% each. These two haplotypes, and hence the rs10774671-G allele, were significantly associated with protection against severe COVID-19 (p = 0.034, p = 0.041, and p = 0.008, respectively). Surprisingly, in men with the Berber-specific uniparental markers, the African haplotype was absent, while the prevalence of the Neanderthal haplotype was similar to that in Europeans. The protective rs10774671-G allele of OAS1 was found only in the Neanderthal haplotype in Berbers, the indigenous people of North Africa, suggesting that this region may have served as a stepping-stone for the passage of hominids to other continents. (© 2024. The Author(s).)
References:	Harapan H, Itoh N, Yufika A, Winardi W, Keam S, Te H, Megawati D, Hayati Z, Wagner AL, Mudatsir M (2020) Coronavirus disease 2019 (COVID-19): A literature review. J Infect Pub Health 13:667–673. https://doi.org/10.1016/j.jiph.2020.03.019. (PMID: 10.1016/j.jiph.2020.03.019) Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W (2020) A novel coronavirus from patients with pneumonia in China, 2019. New Engl J Med 382:727–733. https://doi.org/10.1056/nejmoa2001017. (PMID: 10.1056/nejmoa200101731978945) Ranjan J, Ravindra A, Mishra B (2021) Gender and genetic factors impacting COVID-19 severity. J Family Med Prim Care 10:3956–3963. https://doi.org/10.4103/jfmpc.jfmpc_769_21. (PMID: 10.4103/jfmpc.jfmpc_769_21351367528797126) Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D et al (2020) Genetic mechanisms of critical illness in COVID-19. Nature 591:92–98. https://doi.org/10.1038/s41586-020-03065-y. (PMID: 10.1038/s41586-020-03065-y33307546) Zhou S, Hill CS, Sarkar S, Tse LV, Woodburn BMD, Schinazi RF, Sheahan TP, Baric RS, Heise MT, Swanstrom R (2021) β-d-N 4-hydroxycytidine inhibits SARS-CoV-2 through lethal mutagenesis but is also mutagenic to mammalian cells. J Infect Dis 224:415–419. https://doi.org/10.1093/infdis/jiab247. (PMID: 10.1093/infdis/jiab247339616958136050) Zeberg H, Pääbo S (2021) A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Proc Natl Acad Sci USA 118:e2026309118. https://doi.org/10.1073/pnas.2026309118. (PMID: 10.1073/pnas.2026309118335939417936282) Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Papenberg BW, Zahoor M et al (2022) Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nat Genet 54:1103–1116. https://doi.org/10.1038/s41588-022-01113-z. (PMID: 10.1038/s41588-022-01113-z358359139355882) Huffman JE, Butler-Laporte G, Khan A, Pairo-Castineira E, Drivas TG, Peloso GM, Nakanishi T, COVID-19 Host Genetics Initiative, Ganna A, Verma A, Baillie JK, Kiryluk K, Richards JB, Zeberg H (2022) Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. Nat Genet 54:125–127. https://doi.org/10.1038/s41588-021-00996-8. (PMID: 10.1038/s41588-021-00996-8350277408837537) Kjær KH, Pahus J, Hansen MF, Poulsen JB, Christensen EI, Justesen J, Martensen PM (2014) Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism. BMC Cell Biol 15:33. https://doi.org/10.1186/1471-2121-15-33. (PMID: 10.1186/1471-2121-15-33252054664165621) Choi UY, Kang JS, Hwang YS, Kim YJ (2015) Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases. Exp Mol Med 47:e144. https://doi.org/10.1038/emm.2014.110. (PMID: 10.1038/emm.2014.110257442964351405) Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML et al (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science 374:eabj3624. https://doi.org/10.1126/science.abj3624. (PMID: 10.1126/science.abj3624345816227612834) Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AE, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M Jr, Savan R (2021) Endomembrane targeting of human OAS1 p46 augments antiviral activity. Elife 10:e71047. https://doi.org/10.7554/eLife.71047. (PMID: 10.7554/eLife.71047343425788357416) Lim JK, Lisco A, McDermott DH, Huynh L, Ward JM, Johnson B, Johnson H, Pape J, Foster GA, Krysztof D, Follmann D, Stramer SL, Margolis LB, Murphy PM (2009) Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. PLoS Pathog 5:e1000321. https://doi.org/10.1371/journal.ppat.1000321. (PMID: 10.1371/journal.ppat.1000321192474382642680) O’Brien M, Lonergan R, Costelloe L, O’Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O’Farrelly C, Hutchinson M, Tubridy N (2010) OAS1: a multiple sclerosis susceptibility gene that influences disease severity. Neurology 75:411–418. https://doi.org/10.1212/wnl.0b013e3181ebdd2b. (PMID: 10.1212/wnl.0b013e3181ebdd2b20679634) Mandal S, Abebe F, Chaudhary J (2011) 2′-5′ oligoadenylate synthetase 1 polymorphism is associated with prostate cancer. Cancer 117:5509–5518. https://doi.org/10.1002/cncr.26219. (PMID: 10.1002/cncr.2621921638280) Sams AJ, Dumaine A, Nédélec Y, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB (2016) Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol 17:246. https://doi.org/10.1186/s13059-016-1098-6. (PMID: 10.1186/s13059-016-1098-6278991335129249) Liu X, Xing H, Gao W, Yu D, Zhao Y, Shi X, Zhang K, Li P, Yu J, Xu W, Shan H, Zhang K, Bao W, Fu X, Yang S, Wang S (2017) A functional variant in the OAS1 gene is associated with Sjögren’s syndrome complicated with HBV infection. Sci Rep 7:17571. https://doi.org/10.1038/s41598-017-17931-9. (PMID: 10.1038/s41598-017-17931-9292425595730593) Wu S, Wang Y, Chen G, Zhang M, Wang M, He JQ (2018) 2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study. BMC Pulm Med 18:180. https://doi.org/10.1186/s12890-018-0746-x. (PMID: 10.1186/s12890-018-0746-x304974216267069) Zeberg H, Pääbo S (2020) The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature 587:610–612. https://doi.org/10.1038/s41586-020-2818-3. (PMID: 10.1038/s41586-020-2818-332998156) Ben El Haj R, Salmi A, Regragui W, Moussa A, Bouslam N, Tibar H, Benomar A, Yahyaoui M, Bouhouche A (2017) Evidence for prehistoric origins of the G2019S mutation in the North African Berber population. PLoS One 12:e0181335. https://doi.org/10.1371/journal.pone.0181335. (PMID: 10.1371/journal.pone.0181335287239525517005) Schöley J, Aburto JM, Kashnitsky I, Kniffka MS, Zhang L, Jaadla H, Dowd JB, Kashyap R (2022) Life expectancy changes since COVID-19. Nat Hum Behav 6(12):1649–1659. https://doi.org/10.1038/s41562-022-01450-3. (PMID: 10.1038/s41562-022-01450-3362535209755047) Botigué LR, Henn BM, Gravel S, Maples BK, Gignoux CR, Corona E, Atzmon G, Burns E, Ostrer H, Flores C, Bertranpetit J, Comas D, Bustamante CD (2013) Gene flow from North Africa contributes to differential human genetic diversity in southern Europe. Proc Natl Acad Sci USA 110:11791–11796. https://doi.org/10.1073/pnas.1306223110. (PMID: 10.1073/pnas.1306223110237339303718088) Schuenemann VJ, Peltzer A, Welte B, van Pelt WP, Molak M, Wang CC, Furtwängler A, Urban C, Reiter E, Nieselt K, Teßmann B, Francken M, Harvati K, Haak W, Schiffels S, Krause J (2017) Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods. Nat Commun 8:15694. https://doi.org/10.1038/ncomms15694. (PMID: 10.1038/ncomms15694285568245459999) Pakstis AJ, Gurkan C, Dogan M, Balkaya HE, Dogan S, Neophytou PI et al (2019) Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs. Eur J Hum Genet 27:1885–1893. https://doi.org/10.1038/s41431-019-0466-6. (PMID: 10.1038/s41431-019-0466-6312855306871633) van de Loosdrecht M, Bouzouggar A, Humphrey L, Posth C, Barton N, Aximu-Petri A, Nickel B, Nagel S, Talbi EH, El Hajraoui MA, Amzazi S, Hublin JJ, Pääbo S, Schiffels S, Meyer M, Haak W, Jeong C, Krause J (2018) Pleistocene North African genomes link near Eastern and sub-Saharan African human populations. Science 360:548–552. https://doi.org/10.1126/science.aar8380. (PMID: 10.1126/science.aar838029545507) Lesage S, Patin E, Condroyer C, Leutenegger AL, Lohmann E, Giladi N et al (2010) Parkinson’s disease-related LRRK2 G2019S mutation results from independent mutational events in humans. Hum Mol Genet 19:1998–2004. https://doi.org/10.1093/hmg/ddq081. (PMID: 10.1093/hmg/ddq08120197411) Bruner E, Pearson O (2013) Neurocranial evolution in modern humans: the case of Jebel Irhoud 1. Anthropol Sci 121:31–41. https://doi.org/10.1537/ase.120927. (PMID: 10.1537/ase.120927) Kennedy KAR (1992) Continuity or Replacement: Controversies in Homo sapiens evolution (1st ed.). In: Bräuer G and Smith FH (ed). Rotterdam, Netherlands and Brookfield. https://doi.org/10.1002/ajpa.1330890213. Hublin JJ, Ben-Ncer A, Bailey SE, Freidline SE, Neubauer SMM, Bergmann I, Le Cabec A, Benazzi S, Harvati K, Gunz P (2017) New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens. Nature 546:289–292. https://doi.org/10.1038/nature22336. (PMID: 10.1038/nature2233628593953) Mounier A, Mirazón LM (2019) Deciphering African late middle Pleistocene hominin diversity and the origin of our species. Nat Commun 10:3406. https://doi.org/10.1038/s41467-019-11213-w. (PMID: 10.1038/s41467-019-11213-w315064226736881) Crooks L, Cooper-Knock J, Heath PR, Bouhouche A, Elfahime M, Azzouz M, Bakri Y, Adnaoui M, Ibrahimi A, Amzazi S, Tazi-Ahnini R (2020) Identification of single nucleotide variants in the Moroccan population by whole-genome sequencing. BMC Genet 21:111. https://doi.org/10.1186/s12863-020-00917-4. (PMID: 10.1186/s12863-020-00917-4329579657507649) Sánchez-Quinto F, Botigué LR, Civit S, Arenas C, Avila-Arcos MC, Bustamante CD, Comas D, Lalueza-Fox C (2012) North African populations carry the signature of admixture with Neandertals. PLoS One 7:e47765. https://doi.org/10.1371/journal.pone.0047765. (PMID: 10.1371/journal.pone.0047765230822123474783) Arambourg C (1962) Découverte au Maroc d'un crâne de Néanderthalien. Bulletin de la Société Préhistorique Française 59-7-8:513-514. Mohib A, Raynal JP, Gallotti R, Daujeard C, El Graoui M, Fernandes P, Geraads D, Magoga L, Rué M, Sbihi-Alaoui FZ, Lefèvre D (2019) Forty Years of Research at Casablanca (Morocco): New Insights in the Early/Middle Pleistocene Archaeology and Geology. Hespéris-Tamuda, Eléments d’Archéologie préhistorique marocaine LIV (3):25-56. hal-03067997. Gallotti R, Muttoni G, Lefèvre D, Degeai JP, Geraads D, Zerboni A, Andrieu-Ponel V, Maron M, Perini S, El Graoui M, Sanz-Laliberté S, Daujeard C, Fernandes P, Rué M, Magoga L, Mohib A, Raynal JP (2021) First high resolution chronostratigraphy for the early North African Acheulean at Casablanca (Morocco). Sci Rep 11:15340. https://doi.org/10.1038/s41598-021-94695-3. (PMID: 10.1038/s41598-021-94695-3343215528319413)
المشرفين على المادة:	EC 2.7.7.84 (2',5'-Oligoadenylate Synthetase) EC 2.7.7.- (OAS1 protein, human)
تواريخ الأحداث:	Date Created: 20240424 Date Completed: 20240425 Latest Revision: 20240523
رمز التحديث:	20240523
مُعرف محوري في PubMed:	PMC11043147
DOI:	10.1007/s00705-024-06038-y
PMID:	38658463
قاعدة البيانات:	MEDLINE

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تدمد:	1432-8798
DOI:	10.1007/s00705-024-06038-y