دورية أكاديمية
Alternative splicing in prostate cancer progression and therapeutic resistance.
العنوان: | Alternative splicing in prostate cancer progression and therapeutic resistance. |
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المؤلفون: | Rawat C; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA., Heemers HV; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. heemerh@ccf.org. |
المصدر: | Oncogene [Oncogene] 2024 May; Vol. 43 (22), pp. 1655-1668. Date of Electronic Publication: 2024 Apr 24. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2002->: Basingstoke : Nature Publishing Group Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987- |
مواضيع طبية MeSH: | Alternative Splicing*/genetics , Drug Resistance, Neoplasm*/genetics , Disease Progression* , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/pathology , Prostatic Neoplasms, Castration-Resistant*/therapy , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/therapy, Humans ; Male ; Gene Expression Regulation, Neoplastic ; Animals |
مستخلص: | Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men. CaP mortality results from diverse molecular mechanisms that mediate resistance to the standard of care treatments for metastatic disease. Recently, alternative splicing has been recognized as a hallmark of CaP aggressiveness. Alternative splicing events cause treatment resistance and aggressive CaP behavior and are determinants of the emergence of the two major types of late-stage treatment-resistant CaP, namely castration-resistant CaP (CRPC) and neuroendocrine CaP (NEPC). Here, we review recent multi-omics data that are uncovering the complicated landscape of alternative splicing events during CaP progression and the impact that different gene transcript isoforms can have on CaP cell biology and behavior. We discuss renewed insights in the molecular machinery by which alternative splicing occurs and contributes to the failure of systemic CaP therapies. The potential for alternative splicing events to serve as diagnostic markers and/or therapeutic targets is explored. We conclude by considering current challenges and promises associated with splicing-modulating therapies, and their potential for clinical translation into CaP patient care. (© 2024. The Author(s).) |
References: | Cancer Res. 2019 Oct 15;79(20):5204-5217. (PMID: 31431456) Trends Cell Biol. 2011 Jun;21(6):336-43. (PMID: 21514162) Oncogene. 2015 Aug 13;34(33):4311-9. (PMID: 25381816) Oncotarget. 2013 May;4(5):691-704. (PMID: 23674566) Cancer Cell. 2017 Dec 11;32(6):792-806.e7. (PMID: 29153843) Cell. 1988 Jul 29;54(3):393-401. (PMID: 2840206) Cancer Cell Int. 2023 Jan 17;23(1):8. (PMID: 36650528) Cancer Res. 2010 Feb 1;70(3):1256-64. (PMID: 20086173) Cancer Res. 2006 Mar 1;66(5):2815-25. (PMID: 16510604) Discov Oncol. 2023 Nov 29;14(1):215. (PMID: 38019357) Nat Genet. 2008 Dec;40(12):1413-5. (PMID: 18978789) Mol Syst Biol. 2011 Nov 08;7:548. (PMID: 22068331) J Exp Clin Cancer Res. 2021 Dec 2;40(1):382. (PMID: 34857016) Transl Androl Urol. 2021 Jul;10(7):3056-3068. (PMID: 34430408) Mol Cell. 2006 Jun 23;22(6):769-781. (PMID: 16793546) Blood. 2015 Feb 26;125(9):1367-76. (PMID: 25550361) Front Oncol. 2023 Jun 05;13:1152087. (PMID: 37342192) Mol Biol Rep. 2022 Jun;49(6):4237-4246. (PMID: 35286517) Cell. 2007 Nov 16;131(4):718-29. (PMID: 18022366) Front Genet. 2021 Jul 20;12:700744. (PMID: 34354740) Brief Bioinform. 2019 Sep 27;20(5):1754-1768. (PMID: 29931155) N Engl J Med. 2011 Dec 29;365(26):2497-506. (PMID: 22150006) Lab Invest. 2020 Apr;100(4):570-582. (PMID: 31772313) Cancer Res. 2009 Jan 1;69(1):16-22. (PMID: 19117982) Hum Genomics. 2023 Nov 3;17(1):97. (PMID: 37924098) Mol Carcinog. 2020 Jan;59(1):45-55. (PMID: 31659808) J Clin Oncol. 2018 Aug 20;36(24):2492-2503. (PMID: 29985747) Nat Commun. 2017 Jun 30;8:15921. (PMID: 28665395) Cancer Cell. 2011 Dec 13;20(6):768-80. (PMID: 22172722) Exp Dermatol. 2011 Aug;20(8):685-8. (PMID: 21649738) Eur Urol. 2017 Jan;71(1):68-78. (PMID: 27180064) Elife. 2021 Sep 13;10:. (PMID: 34515025) Nat Rev Mol Cell Biol. 2023 Apr;24(4):242-254. (PMID: 36229538) Cancer Res. 2016 May 1;76(9):2731-42. (PMID: 27197266) Clin Cancer Res. 2019 Mar 15;25(6):1880-1888. (PMID: 30301829) Int J Oncol. 2005 Mar;26(3):635-40. (PMID: 15703818) Mol Cancer Res. 2019 Oct;17(10):2115-2125. (PMID: 31266816) Mol Cell. 2012 Jun 29;46(6):884-92. (PMID: 22749401) N Engl J Med. 2011 Oct 13;365(15):1384-95. (PMID: 21995386) J Clin Oncol. 2023 Sep 10;41(26):4267-4278. (PMID: 37429011) Clin Cancer Res. 2018 Nov 1;24(21):5433-5444. (PMID: 30042207) Tumour Biol. 2016 Feb;37(2):2655-63. (PMID: 26404131) Hum Mol Genet. 2016 Aug 15;25(16):3454-3466. (PMID: 27378699) Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5207-E5215. (PMID: 28611215) Mol Cancer Res. 2015 Feb;13(2):305-18. (PMID: 25274489) Int J Oncol. 2018 Dec;53(6):2473-2487. (PMID: 30221674) Annu Rev Biochem. 2003;72:291-336. (PMID: 12626338) Cell Rep. 2022 Sep 27;40(13):111404. (PMID: 36170835) Nucleic Acids Res. 2013 May;41(9):4949-62. (PMID: 23519612) J Cell Mol Med. 2023 Sep;27(18):2684-2700. (PMID: 37559353) Cancer Sci. 2020 Aug;111(8):3020-3031. (PMID: 32530556) Nucleic Acids Res. 2013 Jan;41(Database issue):D132-41. (PMID: 23118483) Nat Genet. 1995 Apr;9(4):401-6. (PMID: 7795646) Cancer Res. 2008 Jun 1;68(11):4447-54. (PMID: 18519708) Nature. 2016 May 02;534(7605):47-54. (PMID: 27135926) Cancer. 2018 Jul 1;124(13):2758-2765. (PMID: 29660836) Cancer Cell. 2018 Dec 10;34(6):996-1011.e8. (PMID: 30537516) Cell Rep. 2018 Jan 16;22(3):809-819. (PMID: 29346776) Cancer Cell. 2018 Aug 13;34(2):211-224.e6. (PMID: 30078747) Gene. 2023 May 25;866:147330. (PMID: 36871670) Nature. 2016 Mar 3;531(7592):47-52. (PMID: 26909576) Oncogene. 2020 Sep;39(39):6172-6189. (PMID: 32820253) Mol Cell. 2012 Jun 29;46(6):871-83. (PMID: 22749400) Oncogene. 2019 Oct;38(40):6678-6695. (PMID: 31391553) Biochem Genet. 2023 Dec;61(6):2242-2259. (PMID: 37010714) Nucleic Acids Res. 2006;34(14):3955-67. (PMID: 16914448) Endocr Relat Cancer. 2016 Dec;23(12):T199-T210. (PMID: 27702752) Cell Rep. 2021 Jul 27;36(4):109439. (PMID: 34320353) Cancer Res. 2000 Dec 15;60(24):7142-8. (PMID: 11156423) Elife. 2019 Sep 03;8:. (PMID: 31478829) Nat Genet. 2013 Feb;45(2):133-5. (PMID: 23313955) J Cancer. 2019 Sep 7;10(22):5585-5596. (PMID: 31632503) Science. 2022 May 27;376(6596):eabe1505. (PMID: 35617398) Nat Genet. 2018 Nov;50(11):1584-1592. (PMID: 30297968) J Mol Biol. 1994 Jun 10;239(3):357-65. (PMID: 8201617) Nature. 2008 Nov 27;456(7221):470-6. (PMID: 18978772) Transl Res. 2019 Oct;212:89-103. (PMID: 31344348) Sci Rep. 2017 Jan 20;7:41130. (PMID: 28106138) Sci Rep. 2019 Nov 14;9(1):16794. (PMID: 31727962) Cell Mol Life Sci. 2004 Jul;61(14):1764-74. (PMID: 15241552) CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. (PMID: 38230766) Clin Cancer Res. 2009 Sep 1;15(17):5338-49. (PMID: 19706803) Nat Med. 2018 May;24(4):497-504. (PMID: 29457796) Nature. 2015 Oct 22;526(7574):525-30. (PMID: 26466571) EBioMedicine. 2018 Sep;35:167-177. (PMID: 30100395) Cancer Res. 1995 Apr 1;55(7):1441-3. (PMID: 7882349) Nature. 2013 Nov 14;503(7475):229-34. (PMID: 24196718) Cell Rep. 2020 May 26;31(8):107669. (PMID: 32460015) Cancer Cell. 2011 May 17;19(5):575-86. (PMID: 21575859) Nature. 2010 Jan 21;463(7279):364-8. (PMID: 20010808) Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10461-10466. (PMID: 28893982) ACS Med Chem Lett. 2020 May 01;11(6):1310-1315. (PMID: 32551017) Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2220190120. (PMID: 37399401) Nature. 2012 Jul 12;487(7406):239-43. (PMID: 22722839) Nature. 2011 Sep 11;478(7367):64-9. (PMID: 21909114) Science. 1996 Mar 22;271(5256):1716-8. (PMID: 8596930) Biochim Biophys Acta Gene Regul Mech. 2020 Dec;1863(12):194642. (PMID: 33017668) Mol Cell Biochem. 2013 Jul;379(1-2):191-9. (PMID: 23644876) Nat Commun. 2022 Jan 10;13(1):141. (PMID: 35013146) Genomics. 2021 May;113(3):1234-1246. (PMID: 33705884) Nat Rev Genet. 2014 Oct;15(10):689-701. (PMID: 25112293) Nat Chem Biol. 2007 Sep;3(9):570-5. (PMID: 17643112) Nat Chem Biol. 2007 Sep;3(9):576-83. (PMID: 17643111) BMC Genomics. 2019 Aug 30;20(1):686. (PMID: 31470809) ACS Chem Biol. 2011 Mar 18;6(3):229-33. (PMID: 21138297) Nat Med. 2006 Feb;12(2):175-7. (PMID: 16444267) J Biol Chem. 2001 Nov 23;276(47):43850-9. (PMID: 11571276) N Engl J Med. 2004 Oct 7;351(15):1502-12. (PMID: 15470213) Nat Med. 2016 Mar;22(3):298-305. (PMID: 26855148) Molecules. 2019 Feb 20;24(4):. (PMID: 30791548) J Biol Chem. 2002 Dec 20;277(51):49374-82. (PMID: 12381725) Cancer Cell. 2005 Nov;8(5):393-406. (PMID: 16286247) N Engl J Med. 2014 Sep 11;371(11):1028-38. (PMID: 25184630) Nat Genet. 2018 May;50(5):645-651. (PMID: 29610475) Mol Cell. 2023 Jun 15;83(12):1983-2002.e11. (PMID: 37295433) Cell Rep. 2022 Jun 21;39(12):110985. (PMID: 35732114) Genome Res. 2006 Jan;16(1):66-77. (PMID: 16344558) Mol Cell. 2003 Aug;12(2):525-32. (PMID: 14536091) Clin Epigenetics. 2015 Apr 03;7:40. (PMID: 25859291) Science. 2018 Oct 5;362(6410):91-95. (PMID: 30287662) Nucleic Acids Res. 2010 Dec;38(22):8348-56. (PMID: 20719743) Clin Cancer Res. 2014 Mar 15;20(6):1590-600. (PMID: 24449822) Cancer Discov. 2017 Jan;7(1):54-71. (PMID: 27784708) Diagn Pathol. 2011 Sep 28;6:91. (PMID: 21955582) Br J Cancer. 2020 Sep;123(6):1024-1032. (PMID: 32581342) Clin Cancer Res. 2011 Mar 15;17(6):1561-70. (PMID: 21278242) Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5269-5279. (PMID: 32086391) Cell. 2012 Sep 14;150(6):1107-20. (PMID: 22980975) Clin Cancer Res. 2008 Aug 1;14(15):4719-25. (PMID: 18676740) Bioorg Med Chem. 2020 Oct 15;28(20):115712. (PMID: 33069070) RNA. 2008 Aug;14(8):1459-62. (PMID: 18567814) Cancer Res. 2008 Jul 1;68(13):5469-77. (PMID: 18593950) Nat Commun. 2020 Apr 29;11(1):2089. (PMID: 32350277) Comput Struct Biotechnol J. 2020 Dec 24;19:183-195. (PMID: 33425250) Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):189-92. (PMID: 12502788) Acta Pharmacol Sin. 2015 Jan;36(1):3-23. (PMID: 24909511) Cancer Res. 2012 Jul 15;72(14):3457-62. (PMID: 22710436) Cancer Discov. 2021 Aug;11(8):1938-1951. (PMID: 33811047) Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18583-8. (PMID: 17998536) Endocr Relat Cancer. 2014 Aug;21(4):T87-T103. (PMID: 24859991) Mol Cell. 2013 Apr 25;50(2):223-35. (PMID: 23562324) J Clin Invest. 2010 Aug;120(8):2715-30. (PMID: 20644256) Cancer Cell. 2019 Mar 18;35(3):414-427.e6. (PMID: 30889379) Org Biomol Chem. 2016 Jun 21;14(23):5263-71. (PMID: 27188838) JAMA Oncol. 2015 Aug;1(5):582-91. (PMID: 26181238) Bioorg Med Chem Lett. 2023 Jul 15;91:129333. (PMID: 37207846) Int J Biochem Cell Biol. 2017 Oct;91(Pt B):102-115. (PMID: 28552434) EBioMedicine. 2020 Jan;51:102547. (PMID: 31902674) Cancer Res. 2023 Dec 15;83(24):4142-4160. (PMID: 37801613) Cell. 2015 Jul 16;162(2):454. (PMID: 28843286) BMC Genomics. 2006 Dec 27;7:325. (PMID: 17192196) Tumour Biol. 2015 Aug;36(8):6083-93. (PMID: 25833691) Nat Commun. 2018 Mar 21;9(1):1176. (PMID: 29563510) J Clin Invest. 1995 Feb;95(2):515-20. (PMID: 7860733) Cell. 2013 Jan 31;152(3):453-66. (PMID: 23374342) Mol Ther Methods Clin Dev. 2022 Mar 17;25:147-157. (PMID: 35402635) J Clin Pathol. 2007 Nov;60(11):1238-43. (PMID: 17259299) Cancer Res. 2000 Jan 1;60(1):56-9. (PMID: 10646852) Clin Cancer Res. 2015 Oct 15;21(20):4698-708. (PMID: 26071481) Nucleic Acids Res. 1998 Jan 15;26(2):687. (PMID: 9480454) Nat Rev Mol Cell Biol. 2005 May;6(5):386-98. (PMID: 15956978) N Engl J Med. 2016 Jan 21;374(3):286. (PMID: 26789884) BMC Bioinformatics. 2006 Apr 11;7:202. (PMID: 16608523) Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8655-60. (PMID: 18559850) Nat Commun. 2017 Dec 13;8(1):2100. (PMID: 29235465) Nat Genet. 2023 Dec;55(12):2117-2128. (PMID: 38036788) Nat Genet. 2013 Aug;45(8):933-6. (PMID: 23793026) Genome Res. 2002 Aug;12(8):1231-45. (PMID: 12176931) Nat Rev Mol Cell Biol. 2003 Dec;4(12):960-70. (PMID: 14685174) Steroids. 2013 Jun;78(6):548-54. (PMID: 23380368) Int J Cancer. 2017 Aug 15;141(4):731-743. (PMID: 28510291) |
معلومات مُعتمدة: | R01 CA248048 United States CA NCI NIH HHS; CA248048 U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI); N/A Republic of Korea National Cancer Center; CA166440 U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) |
تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240529 Latest Revision: 20240701 |
رمز التحديث: | 20240702 |
مُعرف محوري في PubMed: | PMC11136669 |
DOI: | 10.1038/s41388-024-03036-x |
PMID: | 38658776 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1476-5594 |
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DOI: | 10.1038/s41388-024-03036-x |