دورية أكاديمية
أعرض في EDS

Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis.

التفاصيل البيبلوغرافية
العنوان: Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis.
المؤلفون: Jeung D; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Lee GE; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Chen W; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Byun J; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Nam SB; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea.; Biopharmaceutical research center, Ochang Institute of Biological and Environmental Science, Korea Basic Science Institute, 162, Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, 28119, Republic of Korea., Park YM; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Lee HS; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Kang HC; College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Lee JY; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea., Kim KD; Division of Life Sciences, Gyeongsang National University, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, South Korea., Hong YS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, 30, Yeongudanji-ro, Ochang-eup, Cheongju-si, Chongbuk, 28116, South Korea., Lee CJ; Biopharmaceutical research center, Ochang Institute of Biological and Environmental Science, Korea Basic Science Institute, 162, Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, 28119, Republic of Korea., Kim DJ; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, MBMRF, 1.410, 5300, North L St., McAllen, TX, 78504, USA., Cho YY; BK21-4Th Team, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14662, South Korea. yongyeon@catholic.ac.kr.
المصدر: Scientific reports [Sci Rep] 2024 Apr 24; Vol. 14 (1), pp. 9440. Date of Electronic Publication: 2024 Apr 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Ribosomal Protein S6 Kinases, 90-kDa*/metabolism , Ribosomal Protein S6 Kinases, 90-kDa*/genetics , Melanins*/biosynthesis , Melanins*/metabolism , alpha-MSH*/metabolism , alpha-MSH*/pharmacology , Signal Transduction* , Pteridines*, Animals ; Mice ; Cell Line, Tumor ; Forkhead Transcription Factors/metabolism ; Forkhead Transcription Factors/genetics ; Ultraviolet Rays ; Morpholines/pharmacology ; Chromones/pharmacology ; Nitriles/pharmacology ; Butadienes/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Melanoma, Experimental/metabolism ; Melanogenesis
مستخلص: Although previous studies have examined the signaling pathway involved in melanogenesis through which ultraviolet (UV) or α-melanocyte-stimulating hormones (α-MSH) stimuli act as key inducers to produce melanin at the stratum basal layer of the epidermis, the signaling pathway regulating melanogenesis is still controversial. This study reports that α-MSH, not UVA and UVB, acted as a major stimulus of melanogenesis in B16F10 melanoma cells. Signaling pathway analysis using gene knockdown technology and chemical inhibitors, the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)/p90 ribosomal S6 kinase 2 (RSK2) played an important role in melanogenesis. Unexpectedly, LY294002, a PI3K inhibitor, increased melanogenesis without UV or α-MSH stimulation, suggesting that the PI3K/AKT signaling pathway may not be a major signaling pathway for melanogenesis. Chemical inhibition of the MEKs/ERKs/RSK2 signaling pathway using U0126 or BI-D1870 suppressed melanogenesis by stimulation of UVA or α-MSH stimulation, or both. In particular, the genetic depletion of RSK2 or constitutive active (CA)-RSK2 overexpression showed that RSK2 plays a key role in melanogenesis. Interestingly, forkhead box protein O4 (FOXO4) was phosphorylated by RSK2, resulting in the increase of FOXO4's transactivation activity. Notably, the FOXO4 mutant harboring serine-to-alanine replacement at the phosphorylation sites totally abrogated the transactivation activity and reduced melanin production, indicating that RSK2-mediated FOXO4 activity plays a key role in melanogenesis. Furthermore, kaempferol, a flavonoid inhibiting the RSK2 activity, suppressed melanogenesis. In addition, FOXO4-wt overexpression showed that FOXO4 enhance melanin synthesis. Overall, the RSK2-FOXO4 signaling pathway plays a key role in modulating melanogenesis.
(© 2024. The Author(s).)
References: Int J Mol Sci. 2013 Jun 07;14(6):12222-48. (PMID: 23749111)
Biochem Biophys Res Commun. 2013 Oct 11;440(1):112-8. (PMID: 24055036)
J Biol Chem. 2002 Sep 13;277(37):33690-7. (PMID: 12093801)
Arch Pharm Res. 2021 Dec;44(12):1091-1108. (PMID: 34750753)
Adv Protein Chem Struct Biol. 2019;115:247-295. (PMID: 30798934)
Cancer Res. 2005 May 1;65(9):3596-603. (PMID: 15867353)
Biochem J. 2007 Jan 1;401(1):29-38. (PMID: 17040210)
Cancer Res. 2007 Sep 15;67(18):8725-35. (PMID: 17875713)
Exp Ther Med. 2020 Jul;20(1):173-185. (PMID: 32509007)
Int J Mol Sci. 2017 Feb 03;18(2):. (PMID: 28165370)
J Cancer Prev. 2015 Sep;20(3):165-71. (PMID: 26473154)
Physiol Rev. 2018 Oct 1;98(4):2381-2430. (PMID: 30156493)
Physiol Rev. 2004 Oct;84(4):1155-228. (PMID: 15383650)
J Biotechnol. 2021 Dec 10;342:114-127. (PMID: 34757047)
Cancer Res. 2009 May 15;69(10):4398-406. (PMID: 19435896)
Int J Mol Sci. 2019 Apr 23;20(8):. (PMID: 31018569)
J Mol Endocrinol. 2019 Apr 1;62(3):R239-R253. (PMID: 30780132)
Polymers (Basel). 2021 May 20;13(10):. (PMID: 34065580)
J Biol Chem. 2011 Aug 5;286(31):27111-22. (PMID: 21659537)
Int J Cosmet Sci. 2018 Aug;40(4):328-347. (PMID: 29752874)
Lab Invest. 2017 Jun;97(6):649-656. (PMID: 28263292)
Cancer Res. 2005 Feb 1;65(3):1027-34. (PMID: 15705904)
Biochem Biophys Res Commun. 2023 Jan 29;642:66-74. (PMID: 36566564)
Pigment Cell Melanoma Res. 2021 Jul;34(4):748-761. (PMID: 33884776)
Molecules. 2016 Sep 28;21(10):. (PMID: 27689982)
Arch Pharm Res. 2017 Mar;40(3):291-303. (PMID: 28013489)
Mol Biol Cell. 1995 Aug;6(8):1025-35. (PMID: 7579705)
J Cancer Prev. 2014 Sep;19(3):199-208. (PMID: 25337589)
Cancer Res. 2005 Apr 15;65(8):3108-16. (PMID: 15833840)
Phytomedicine. 2019 Apr;57:129-136. (PMID: 30668315)
Cell Death Dis. 2018 Mar 14;9(3):401. (PMID: 29540697)
Front Oncol. 2013 Aug 05;3:201. (PMID: 23936765)
Phytomedicine. 2019 Apr;57:57-64. (PMID: 30668323)
Int J Dermatol. 2010 Sep;49(9):978-86. (PMID: 20883261)
Sci Rep. 2020 Sep 1;10(1):14374. (PMID: 32873804)
Science. 2005 May 27;308(5726):1318-21. (PMID: 15919995)
J Biol Chem. 2002 Aug 2;277(31):27733-41. (PMID: 12016217)
Photochem Photobiol. 2008 May-Jun;84(3):539-49. (PMID: 18435612)
Eur J Cancer. 1999 Dec;35(14):2003-9. (PMID: 10711242)
J Investig Dermatol Symp Proc. 1997 Aug;2(1):87-93. (PMID: 9487022)
Int J Mol Sci. 2016 Jul 15;17(7):. (PMID: 27428965)
Int J Mol Sci. 2015 Oct 13;16(10):24219-42. (PMID: 26473849)
Annu Rev Biochem. 1987;56:567-613. (PMID: 2956925)
Curr Biol. 2020 Feb 24;30(4):R142-R143. (PMID: 32097632)
Cancer Res. 2007 Sep 1;67(17):8104-12. (PMID: 17804722)
Free Radic Biol Med. 2012 Feb 1;52(3):626-634. (PMID: 22178978)
Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44. (PMID: 15187187)
J Biol Chem. 2011 Jan 21;286(3):2057-66. (PMID: 21098035)
Curr Pharm Des. 2017 Nov 16;23(29):4247-4258. (PMID: 28714417)
J Biol Chem. 2003 Sep 19;278(38):35959-67. (PMID: 12857750)
J Clin Invest. 1997 Feb 15;99(4):635-42. (PMID: 9045865)
Redox Biol. 2020 Sep;36:101624. (PMID: 32863230)
J Invest Dermatol. 2014 May;134(5):1378-1388. (PMID: 24284420)
معلومات مُعتمدة: 2023R1A2C2003059 Ministry of Science, ICT and Future Planning
فهرسة مساهمة: Keywords: FOXO4; FOXO4 activity; Melanogenesis; RSK2; Signaling pathway
المشرفين على المادة: EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 90-kDa)
0 (Melanins)
581-05-5 (alpha-MSH)
0 (Forkhead Transcription Factors)
0 (Morpholines)
0 (BI D1870)
31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)
0 (Chromones)
0 (Nitriles)
0 (Butadienes)
0 (U 0126)
EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
EC 2.7.11.1 (ribosomal protein S6 kinase, 90kDa, polypeptide 3)
0 (Pteridines)
تواريخ الأحداث: Date Created: 20240424 Date Completed: 20240424 Latest Revision: 20240530
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC11043394
DOI: 10.1038/s41598-024-60165-9
PMID: 38658799
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-60165-9