دورية أكاديمية
Current approaches in smart nano-inspired drug delivery: A narrative review.
| العنوان: | Current approaches in smart nano-inspired drug delivery: A narrative review. |
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| المؤلفون: | Boppana SH; Department of Anesthesia and Critical Care Johns Hopkins School of Medicine Baltimore Maryland USA., Kutikuppala LVS; Department of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India., Sharma S; Department of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India., C M; Department of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India., Rangari G; Department of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India., Misra AK; Department of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India., Kandi V; Department of Microbiology Prathima Institute of Medical Sciences Karimnagar Telangana India., Mishra S; School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India., Singh PK; School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India., Rabaan AA; Molecular Diagnostic Laboratory Johns Hopkins Aramco Healthcare Dhahran Saudi Arabia.; College of Medicine Alfaisal University Riyadh Saudi Arabia.; Department of Public Health and Nutrition The University of Haripur Haripur Pakistan., Mohapatra RK; Department of Chemistry Government College of Engineering Keonjhar Odisha India., Kudrat-E-Zahan M; Department of Chemistry Rajshahi University Rajshahi Bangladesh. |
| المصدر: | Health science reports [Health Sci Rep] 2024 Apr 24; Vol. 7 (4), pp. e2065. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 101728855 Publication Model: eCollection Cited Medium: Internet ISSN: 2398-8835 (Electronic) Linking ISSN: 23988835 NLM ISO Abbreviation: Health Sci Rep Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Hoboken, NJ] : John Wiley and Sons, Inc., [2017]- |
| مستخلص: | Background and Aim: The traditional drug delivery approach involves systemic administration of a drug that could be nonspecific in targeting, low on efficacy, and with severe side-effects. To address such challenges, the field of smart drug delivery has emerged aiming at designing and developing delivery systems that can target specific cells, tissues, and organs and have minimal off-target side-effects. Methods: A literature search was done to collate papers and reports about the currently available various strategies for smart nano-inspired drug delivery. The databases searched were PubMed, Scopus, and Google Scholar. Based on selection criteria, the most pertinent and recent items were included. Results: Smart drug delivery is a cutting-edge revolutionary intervention in modern medicines to ensure effective and safe administration of therapeutics to target sites. These hold great promise for targeted and controlled delivery of therapeutic agents to improve the efficacy with reduced side-effects as compared to the conventional drug delivery approaches. Current smart drug delivery approaches include nanoparticles, liposomes, micelles, and hydrogels, each with its own advantages and limitations. The success of these delivery systems lies in engineering and designing them, and optimizing their pharmacokinetics and pharmacodynamics properties. Conclusion: Development of drug delivery systems that can get beyond various physiological and clinical barriers, as observed in conventionally administered chemotherapeutics, has been possible through recent advancements. Using multifunctional targeting methodologies, smart drug delivery tries to localize therapy to the target location, reduces cytotoxicity, and improves the therapeutic index. Rapid advancements in research and development in smart drug delivery provide wider and more promising avenues to guarantee a better healthcare system, improve patient outcomes, and achieve higher levels of effective medical interventions like personalized medicine. Competing Interests: The authors declare no conflict of interest. (© 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: hydrogels; liposomes; micelles; nanoparticles; smart drug delivery; therapeutics |
| تواريخ الأحداث: | Date Created: 20240425 Latest Revision: 20240426 |
| رمز التحديث: | 20240426 |
| مُعرف محوري في PubMed: | PMC11040566 |
| DOI: | 10.1002/hsr2.2065 |
| PMID: | 38660006 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2398-8835 |
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| DOI: | 10.1002/hsr2.2065 |