دورية أكاديمية
Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer.
العنوان: | Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer. |
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المؤلفون: | Yalamanchali A; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Griffith C; Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA., Reddy CA; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Koyfman SA; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Woody NM; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Campbell SR; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Silver N; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Scharpf J; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lorenz RR; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Prendes B; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Ku JA; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lamarre E; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Geiger JL; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA. |
المصدر: | Head & neck [Head Neck] 2024 Sep; Vol. 46 (9), pp. 2340-2347. Date of Electronic Publication: 2024 Apr 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley And Sons Country of Publication: United States NLM ID: 8902541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0347 (Electronic) Linking ISSN: 10433074 NLM ISO Abbreviation: Head Neck Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York, NY : John Wiley And Sons Original Publication: New York, NY : J. Wiley, c1989- |
مواضيع طبية MeSH: | Mouth Neoplasms*/pathology , Mouth Neoplasms*/mortality , Mouth Neoplasms*/therapy , Mouth Neoplasms*/surgery , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/mortality , Carcinoma, Squamous Cell*/therapy , Carcinoma, Squamous Cell*/surgery , Extranodal Extension*/pathology, Humans ; Male ; Female ; Middle Aged ; Aged ; Disease-Free Survival ; Retrospective Studies ; Neoplasm Staging ; Proportional Hazards Models ; Adult ; Treatment Outcome |
مستخلص: | Background: Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC). Methods: From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics with disease-free survival (DFS) and overall survival (OS). ENE was analyzed as both a dichotomous and continuous variable. Results: A total of 113 patients were identified. Between major (>2 mm) versus minor ENE (≤2 mm), there was no significant difference in DFS (HR 1.18, 95%CI 0.72-1.92, p = 0.51) or OS (HR 1.17, 95%CI 0.70-1.96, p = 0.55). There was no significant association between ENE as a continuous variable and DFS (HR 0.97 per mm, 95%CI 0.87-1.4, p = 0.96) or OS (HR 0.96 per mm, 95%CI 0.83-1.11, p = 0.58). Conclusion: No significant relationship was seen between ENE extent and DFS or OS in individuals with OCSCC. (© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.) |
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فهرسة مساهمة: | Keywords: extranodal extension; oral cavity cancer; squamous cell carcinoma of head and neck |
تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240807 Latest Revision: 20240807 |
رمز التحديث: | 20240807 |
DOI: | 10.1002/hed.27782 |
PMID: | 38660928 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-0347 |
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DOI: | 10.1002/hed.27782 |