دورية أكاديمية
Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer.
| العنوان: | Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer. |
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| المؤلفون: | Yalamanchali A; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Griffith C; Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA., Reddy CA; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Koyfman SA; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Woody NM; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Campbell SR; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA., Silver N; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Scharpf J; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lorenz RR; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Prendes B; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Ku JA; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Lamarre E; Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA., Geiger JL; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA. |
| المصدر: | Head & neck [Head Neck] 2024 Sep; Vol. 46 (9), pp. 2340-2347. Date of Electronic Publication: 2024 Apr 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley And Sons Country of Publication: United States NLM ID: 8902541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0347 (Electronic) Linking ISSN: 10433074 NLM ISO Abbreviation: Head Neck Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : John Wiley And Sons Original Publication: New York, NY : J. Wiley, c1989- |
| مواضيع طبية MeSH: | Mouth Neoplasms*/pathology , Mouth Neoplasms*/mortality , Mouth Neoplasms*/therapy , Mouth Neoplasms*/surgery , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/mortality , Carcinoma, Squamous Cell*/therapy , Carcinoma, Squamous Cell*/surgery , Extranodal Extension*/pathology, Humans ; Male ; Female ; Middle Aged ; Aged ; Disease-Free Survival ; Retrospective Studies ; Neoplasm Staging ; Proportional Hazards Models ; Adult ; Treatment Outcome |
| مستخلص: | Background: Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC). Methods: From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics with disease-free survival (DFS) and overall survival (OS). ENE was analyzed as both a dichotomous and continuous variable. Results: A total of 113 patients were identified. Between major (>2 mm) versus minor ENE (≤2 mm), there was no significant difference in DFS (HR 1.18, 95%CI 0.72-1.92, p = 0.51) or OS (HR 1.17, 95%CI 0.70-1.96, p = 0.55). There was no significant association between ENE as a continuous variable and DFS (HR 0.97 per mm, 95%CI 0.87-1.4, p = 0.96) or OS (HR 0.96 per mm, 95%CI 0.83-1.11, p = 0.58). Conclusion: No significant relationship was seen between ENE extent and DFS or OS in individuals with OCSCC. (© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.) |
| References: | de Almeida JR, Yao CMKL, Ziai H, et al. Postoperative wound infections, neutrophil‐to‐lymphocyte ratio, and cancer recurrence in patients with oral cavity cancer undergoing surgical resection. Oral Oncol. 2019;97:23‐30. doi:10.1016/j.oraloncology.2019.07.023. Mermod M, Tolstonog G, Simon C, Monnier Y. Extracapsular spread in head and neck squamous cell carcinoma: a systematic review and meta‐analysis. Oral Oncol. 2016;62:60‐71. doi:10.1016/j.oraloncology.2016.10.003. Bernier J, Cooper JS, Pajak TF, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27(10):843‐850. doi:10.1002/hed.20279. Bernier J, Ozsahin M, Lefèbvre JL, Maingon P, Cognetti F, van Glabbeke M. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:8‐1952. Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high‐risk squamous‐cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937‐1944. doi:10.1056/NEJMoa032646. Cooper JS, Zhang Q, Pajak TF, et al. Long‐term follow‐up of the RTOG 9501/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high‐risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol. 2012;84(5):1198‐1205. doi:10.1016/j.ijrobp.2012.05.008. Ferris RL, Flamand Y, Weinstein GS, et al. Phase II randomized trial of Transoral surgery and low‐dose intensity modulated radiation therapy in Resectable p16+ locally advanced oropharynx cancer: an ECOG‐ACRIN cancer research group trial (E3311). J Clin Oncol. 2022;40(2):138‐149. doi:10.1200/JCO.21.01752. Chen CC, Lin JC, Chen KW. Lymph node ratio as a prognostic factor in head and neck cancer patients. Radiat Oncol. 2015;10(1):181. doi:10.1186/s13014‐015‐0490‐9. Kim SY, Nam SY, Choi SH, Cho KJ, Roh JL. Prognostic value of lymph node density in node‐positive patients with oral squamous cell carcinoma. Ann Surg Oncol. 2011;18(8):2310‐2317. doi:10.1245/s10434‐011‐1614‐6. Köhler HF, Kowalski LP. Prognostic impact of the level of neck metastasis in oral cancer patients. Braz J Otorhinolaryngol. 2012;78(6):15‐20. doi:10.5935/1808‐8694.20120027. Marchiano E, Patel TD, Eloy JA, Baredes S, Park RCW. Impact of nodal level distribution on survival in oral cavity squamous cell carcinoma: a population‐based study. Otolaryngol Neck Surg. 2016;155(1):99‐105. doi:10.1177/0194599816636356. Lydiatt WM, Patel SG, O'Sullivan B, et al. Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):122‐137. doi:10.3322/caac.21389. Wreesmann VB, Katabi N, Palmer FL, et al. Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma: extent of extranodal spread. Head Neck. 2016;38(S1):E1192‐E1199. doi:10.1002/hed.24190. Mamic M, Lucijanic M, Manojlovic L, Muller D, Suton P, Luksic I. Prognostic significance of extranodal extension in oral cavity squamous cell carcinoma with occult neck metastases. Int J Oral Maxillofac Surg. 2021;50(3):309‐315. doi:10.1016/j.ijom.2020.07.006. de Almeida JR, Truong T, Khan NM, et al. Treatment implications of postoperative chemoradiotherapy for squamous cell carcinoma of the oral cavity with minor and major extranodal extension. Oral Oncol. 2020;110:104845. doi:10.1016/j.oraloncology.2020.104845. Joshi K, Agarwal M, Pasricha S, et al. Macroscopic extranodal extension in oral squamous cell carcinoma‐a subgroup with poor survival. Laryngoscope. 2023;133(3):588‐593. doi:10.1002/lary.30158. Greenberg JS, Fowler R, Gomez J, et al. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer. 2003;97(6):1464‐1470. doi:10.1002/cncr.11202. Best DL, Jazayeri HE, McHugh JB, et al. Extent of extranodal extension in Oral cavity squamous cell carcinoma is not independently associated with overall or disease‐free survival at a 2.0‐mm threshold. J Oral Maxillofac Surg. 2022;80(12):1978‐1988. doi:10.1016/j.joms.2022.08.019. Arun I, Maity N, Hameed S, et al. Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma. Head Neck. 2021;43(2):520‐533. doi:10.1002/hed.26499. Yamada S, Yanamoto S, Otani S, et al. Evaluation of the level of progression of extracapsular spread for cervical lymph node metastasis in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2016;45(2):141‐146. doi:10.1016/j.ijom.2015.09.005. Agarwal JP, Kane S, Ghosh‐Laskar S, et al. Extranodal extension in resected oral cavity squamous cell carcinoma: more to it than meets the eye. Laryngoscope. 2019;129(5):1130‐1136. doi:10.1002/lary.27508. |
| فهرسة مساهمة: | Keywords: extranodal extension; oral cavity cancer; squamous cell carcinoma of head and neck |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240807 Latest Revision: 20240807 |
| رمز التحديث: | 20240807 |
| DOI: | 10.1002/hed.27782 |
| PMID: | 38660928 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0347 |
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| DOI: | 10.1002/hed.27782 |