دورية أكاديمية
Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats.
| العنوان: | Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats. |
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| المؤلفون: | Minko Essono S; Higher Teacher Training College, University of Bertoua, Bertoua, Cameroon., Mvondo MA; Research Unit of Animal Physiology and Phytopharmacology, University of Dschang, Dschang, Cameroon., Wego MTK; Research Unit of Animal Physiology and Phytopharmacology, University of Dschang, Dschang, Cameroon., Kemka Nguimatio FX; Research Unit of Animal Physiology and Phytopharmacology, University of Dschang, Dschang, Cameroon., Momo Tetsatsi AC; Faculty of Health Sciences, University of Bamenda, Bambili, Cameroon., Watcho P; Research Unit of Animal Physiology and Phytopharmacology, University of Dschang, Dschang, Cameroon. |
| المصدر: | Journal of complementary & integrative medicine [J Complement Integr Med] 2024 Apr 26; Vol. 21 (2), pp. 175-183. Date of Electronic Publication: 2024 Apr 26 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2012-> : Berlin : Walter de Gruyter Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004- |
| مواضيع طبية MeSH: | Rats, Wistar* , Plant Extracts*/pharmacology , Seeds*/chemistry , Uterus*/drug effects , Persea*/chemistry , Estradiol* , Vagina*/drug effects , Ovariectomy*, Animals ; Female ; Rats ; Estrogen Antagonists/pharmacology ; Ethanol ; Receptors, Estrogen/metabolism |
| مستخلص: | Objectives: The ethanol extract of Persea americana seeds was found to inhibit the development of estrogen-dependent conditions in female Wistar rats, suggesting the ability of its secondary metabolites to interact with estrogen receptors (ERs), either as partial agonists or as antagonists. To test this hypothesis, the abovementioned extract was assessed for its ability to mimic and/or antagonize estradiol effects. Methods: Two experiments were conducted in ovariectomized (OVX) rats: (1) animals were treated with estradiol valerate (E Results: When administered alone, P. americana did not change the histomorphology of both organs (uterus and vagina). In combination with E Conclusions: The seed extract of P. americana contains ER antagonist secondary metabolites accounting for its ability to inhibit the development of estrogen-dependent conditions in female rats. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.) |
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| فهرسة مساهمة: | Keywords: Persea americana; anti-estrogenic effects; estrogen-receptor antagonists; ovariectomized rat |
| المشرفين على المادة: | 0 (Plant Extracts) 4TI98Z838E (Estradiol) 0 (Estrogen Antagonists) 3K9958V90M (Ethanol) 0 (Receptors, Estrogen) |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1515/jcim-2023-0218 |
| PMID: | 38661065 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1553-3840 |
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| DOI: | 10.1515/jcim-2023-0218 |