دورية أكاديمية
Anti-Coronavirus Potential of Polyether Ionophores: The New Application of Veterinary Antibiotics in Livestock.
| العنوان: | Anti-Coronavirus Potential of Polyether Ionophores: The New Application of Veterinary Antibiotics in Livestock. |
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| المؤلفون: | Zheng Y; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China., Feng J; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China., Yu Y; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China., Ling M; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China., Song Y; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University; Hubei Hongshan Laboratory, Wuhan 430070, China., Xie H; Hangzhou Yanqu Information Technology Co., Ltd., Hangzhou, Zhejiang 310003, China., Zhang M; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University; Hubei Hongshan Laboratory, Wuhan 430070, China., Li W; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University; Hubei Hongshan Laboratory, Wuhan 430070, China., Wang X; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China.; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 May 08; Vol. 72 (18), pp. 10640-10654. Date of Electronic Publication: 2024 Apr 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Ionophores*/pharmacology , Ionophores*/chemistry , Livestock* , CD13 Antigens*/metabolism , CD13 Antigens*/chemistry, Animals ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Coronavirus 3C Proteases/antagonists & inhibitors ; Veterinary Drugs/pharmacology ; Veterinary Drugs/chemistry ; Coronavirus/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Polyether Polyketides |
| مستخلص: | Coronaviruses have consistently posed a major global concern in the field of livestock industry and public health. However, there is currently a lack of efficient drugs with broad-spectrum antiviral activity to address the challenges presented by emerging mutated strains or drug resistance. Additionally, the method for identifying multitarget drugs is also insufficient. Aminopeptidase N (APN) and 3C-like proteinase (3CLpro) represent promising targets for host-directed and virus-directed strategies, respectively, in the development of effective drugs against various coronaviruses. In this study, maduramycin ammonium demonstrated a broad-spectrum antiviral effect by targeting both of the proteins. The binding domains 4 Å from the ligand of both target proteins shared a structural similarity, suggesting that screening and designing drugs based on these domains might exhibit broad-spectrum and highly effective antiviral activity. Furthermore, it was identified that the polyether ionophores' ability to carry zinc ion might be one of the reasons why they were able to target APN and exhibit antiviral effect. The findings of this experiment provide novel perspectives for future drug screening and design, while also offering valuable references for the utilization of polyether ionophores in the management of livestock health. |
| فهرسة مساهمة: | Keywords: coronavirus; drug; dual targeting; livestock health; polyether ionophore |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Ionophores) EC 3.4.11.2 (CD13 Antigens) EC 3.4.22.28 (Coronavirus 3C Proteases) 0 (Veterinary Drugs) 0 (Anti-Bacterial Agents) 0 (Polyether Polyketides) |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240508 Latest Revision: 20240508 |
| رمز التحديث: | 20240508 |
| DOI: | 10.1021/acs.jafc.4c01130 |
| PMID: | 38661066 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.4c01130 |