A Chronic Aquatic Hazard Assessment for the Perfume Raw Material Octahydro-tetramethyl-naphthalenyl-ethanone.

التفاصيل البيبلوغرافية
العنوان:	A Chronic Aquatic Hazard Assessment for the Perfume Raw Material Octahydro-tetramethyl-naphthalenyl-ethanone.
المؤلفون:	Lapczynski A; Research Institute for Fragrance Materials, Mahwah, New Jersey, USA., Belanger SE; The Procter & Gamble Company (retired), Cincinnati, Ohio, USA., Connors K; Environmental Stewardship and Sustainability, The Procter and Gamble Company, Mason, Ohio, USA., Bozich J; International Flavors and Fragrances, New York, New York, USA.
المصدر:	Environmental toxicology and chemistry [Environ Toxicol Chem] 2024 Jun; Vol. 43 (6), pp. 1378-1389. Date of Electronic Publication: 2024 Apr 25.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: SETAC Press Country of Publication: United States NLM ID: 8308958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE
أسماء مطبوعة:	Publication: Pensacola, FL : SETAC Press Original Publication: New York : Pergamon Press, c1982-
مواضيع طبية MeSH:	Water Pollutants, Chemical/toxicity , Naphthalenes/toxicity , Naphthalenes*/chemistry, Animals ; Risk Assessment ; Daphnia/drug effects ; Perfume/toxicity ; Toxicity Tests, Chronic ; Chironomidae/drug effects ; Zebrafish ; Cladocera/drug effects
مستخلص:	Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) is a high-production volume fragrance material used in various down-the-drain consumer products. To assess aquatic risk, the Research Institute for Fragrance Materials (RIFM) uses a tiered data-driven framework to determine a risk characterization ratio, where the ratio of the predicted-environmental concentration to the predicted-no-effect concentration (PNEC) of <1 indicates an acceptable level of risk. Owing to its high production volume and the conservative nature of the RIFM framework, RIFM identified the need to utilize a species sensitivity distribution (SSD) approach to reduce the PNEC uncertainty for OTNE. Adding to the existing Daphnia magna, Danio rerio, and Desmodesmus subspicatus chronic studies, eight new chronic toxicity studies were conducted on the following species: Navicula pelliculosa, Chironomus riparius, Lemna gibba, Ceriodaphnia dubia, Hyalella azteca, Pimephales promelas, Anabaena flos-aquae, and Daphnia pulex. All toxicity data were summarized as chronic 10% effect concentration estimates using the most sensitive biological response. Daphnia magna was the most sensitive (0.032 mg/L), and D. subspicatus was the least sensitive (>2.6 mg/L, the OTNE solubility limit). The 5th percentile hazardous concentration (HC5) derived from the cumulative probability distribution of the chronic toxicity values for the 11 species was determined to be 0.0498 mg/L (95% confidence interval 0.0097-0.1159 mg/L). A series of "leave-one-out" and "add-one-in" simulations indicated the SSD was stable and robust. Add-one-in simulations determined that the probability of finding a species sensitive enough to lower the HC5 two- or threefold was 1/504 and 1/15,300, respectively. Given the high statistical confidence in this robust SSD, an additional application factor protection is likely not necessary. Nevertheless, to further ensure the protection of the environment, an application factor of 2 to the HC5, resulting in a PNEC of 0.0249 mg/L, is recommended. When combined with environmental exposure information, the overall hazard assessment is suitable for a probabilistic environmental risk assessment. Environ Toxicol Chem 2024;43:1378-1389. © 2024 SETAC. (© 2024 SETAC.)
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فهرسة مساهمة:	Keywords: Aquatic toxicology; Ecotoxicology; Fragrance; Hazard/risk assessment; Species sensitivity distributions
المشرفين على المادة:	0 (Water Pollutants, Chemical) 0 (Naphthalenes) 0 (Perfume)
تواريخ الأحداث:	Date Created: 20240425 Date Completed: 20240603 Latest Revision: 20240603
رمز التحديث:	20240603
DOI:	10.1002/etc.5865
PMID:	38661477
قاعدة البيانات:	MEDLINE

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تدمد:	1552-8618
DOI:	10.1002/etc.5865