دورية أكاديمية
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Crocin enhances the sensitivity to paclitaxel in human breast cancer cells by reducing BIRC5 expression.

التفاصيل البيبلوغرافية
العنوان: Crocin enhances the sensitivity to paclitaxel in human breast cancer cells by reducing BIRC5 expression.
المؤلفون: Jia Y; Department of General Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, China., Yang H; Department of Endocrinology, Nanshi Hospital Affiliated to Henan University, Nanyang, China., Yu J; Department of Thyroid and Breast Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, China.; Key Laboratory of Thyroid Tumor Prevention and Treatment of Nanyang, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, China., Li Z; Department of General Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, China., Jia G; Department of Thyroid and Breast Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, China., Ding B; Department of General Surgery, Nanyang First People's Hospital Affiliated to Henan University, Nanyang, China.
المصدر: Chemical biology & drug design [Chem Biol Drug Des] 2024 Feb; Vol. 103 (2), pp. e14467.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell, 2006-
مواضيع طبية MeSH: Paclitaxel*/pharmacology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Survivin*/metabolism , Survivin*/genetics , Carotenoids*/pharmacology , Carotenoids*/chemistry , Apoptosis*/drug effects, Humans ; Female ; MCF-7 Cells ; Drug Resistance, Neoplasm/drug effects ; Cell Survival/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor
مستخلص: Paclitaxel (PTX) is one of the first-line chemotherapeutic agents for treating breast cancer. However, PTX resistance remains a major hurdle in breast cancer therapy. Crocin, the main chemical constituent of saffron, shows anti-cancer activity against various types of cancer. However, the effect of crocin on the resistance of PTX in breast cancer is still unknown. CCK-8 and TUNEL assays were employed to detect cell viability and apoptosis, respectively. The targets of crocin were predicted using HERB database and the targets associated with breast cancer were acquired using GEPIA database. The Venn diagram was utilized to identify the common targets between crocin and breast cancer. Baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5) expression was detected by qRT-PCR and western blot analysis. The correlation between BIRC5 expression and survival was analyzed by Kaplan-Meier plotter and PrognoScan databases. Our data suggested that crocin aggravated PTX-induced decrease of viability and increase of apoptosis in MCF-7 and MCF-7/PTX cells. BIRC5 was identified as the target of crocin against breast cancer. Crocin inhibited BIRC5 expression in MCF-7 and MCF-7/PTX cells. BIRC5 is overexpressed in breast cancer tissues, as well as PTX-sensitive and PTX-resistant breast cancer cells. BIRC5 expression is related to the poor survival of patients with breast cancer. Depletion of BIRC5 strengthened PTX-induced viability reduction and promotion of apoptosis in MCF-7 and MCF-7/PTX cells. Moreover, BIRC5 overexpression reversed the inhibitory effect of crocin on PTX resistance in breast cancer cells. In conclusion, crocin enhanced the sensitivity of PTX in breast cancer cells partially through inhibiting BIRC5 expression.
(© 2024 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: Funder name: Henan Medical Science and Technology Research PlanFunder No. LHGJ20230966 Funder name: Nanyang Basic and Frontier Research Project Funder No. JCQY002.
فهرسة مساهمة: Keywords: BIRC5; apoptosis; breast cancer; crocin; paclitaxel resistance
المشرفين على المادة: 877GWI46C2 (crocin)
P88XT4IS4D (Paclitaxel)
0 (Survivin)
36-88-4 (Carotenoids)
0 (BIRC5 protein, human)
0 (Antineoplastic Agents, Phytogenic)
تواريخ الأحداث: Date Created: 20240425 Date Completed: 20240425 Latest Revision: 20240425
رمز التحديث: 20240425
DOI: 10.1111/cbdd.14467
PMID: 38661582
قاعدة البيانات: MEDLINE
الوصف
تدمد:1747-0285
DOI:10.1111/cbdd.14467