دورية أكاديمية
MORTALITY AND ASSOCIATED FACTORS AMONG INTENSIVE CARE UNIT ADMITTED ADULT PATIENTS WITH MECHANICAL VENTILATION IN ETHIOPIA: A SYSTEMATIC REVIEW AND META-ANALYSIS.
| العنوان: | MORTALITY AND ASSOCIATED FACTORS AMONG INTENSIVE CARE UNIT ADMITTED ADULT PATIENTS WITH MECHANICAL VENTILATION IN ETHIOPIA: A SYSTEMATIC REVIEW AND META-ANALYSIS. |
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| المؤلفون: | Alamaw AW, Abebe GK; Department of Emergency and Critical Care Nursing, School of Nursing, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia., Abate BB; Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia., Tilahun BD; Department of Nursing, School of Nursing, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia., Yilak G; Department of Nursing, School of Nursing, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia., Birara WA; Department Medical Laboratory Sciences, College of Health Sciences, Woldia University, Woldia, Ethiopia., Azmeraw M; Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia., Habtie TE; Department of Nursing, College of Health Sciences, Woldia University, Woldia, Ethiopia., Zemariam AB; Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia. |
| المصدر: | Shock (Augusta, Ga.) [Shock] 2024 May 01; Vol. 61 (5), pp. 660-665. Date of Electronic Publication: 2024 Apr 23. |
| نوع المنشور: | Journal Article; Systematic Review; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Philadelphia : Lippincott Williams & Wilkins Original Publication: Augusta, GA : BioMedical Press, [1994- |
| مواضيع طبية MeSH: | Respiration, Artificial* , Intensive Care Units*, Humans ; Ethiopia/epidemiology ; Hospital Mortality ; Adult |
| مستخلص: | Abstract: Introduction: The global demand for intensive care has risen, given its effectiveness in lowering mortality rates. Mechanical ventilation (MV) is integral to intensive care but introduces risks such as ventilator-associated complications. Ethiopia experiences a high intensive care unit (ICU) mortality rate. Objective: This systematic review and meta-analysis aim to comprehensively synthesize evidence on the mortality of adults undergoing MV in Ethiopia and identify associated factors. Methods: The study extensively searched databases and gray literature for research on MV outcomes, trends, and associated factors in adult ICUs. Adhering to the 2020 PRISMA checklist, a systematic review and meta-analysis sought to establish the mortality rate and key determinants among adult ICU patients on MV. The search incorporated keywords and MeSH terms, excluding studies with unsound methodologies or missing data. Data extraction, quality assessment, and analysis followed established protocols, including the JBI tool for methodological quality evaluation. STATA version 17.0 facilitated analysis, assessing heterogeneity, publication bias, and performing sensitivity and meta-regression analyses. Results: The pooled mortality rate among adult ICU patients undergoing MV was 48.61% (95% CI: 40.82, 56.40%). Significant mortality-contributing factors included medical diagnosis, Glasgow Coma Scale score, sepsis/septic shock, sedation use, multiple-organ dysfunction syndrome, and cardiovascular disease. Although some pooled odds ratios seemed insignificant, closer examination revealed significant associations in individual studies. Conclusion : The study underscores the urgent need for further research, improved ICU infrastructure, and healthcare personnel training in Ethiopia to enhance outcomes for mechanically ventilated patients. Identified factors offer valuable insights for targeted interventions, guiding tailored treatment strategies to reduce mortality. This study contributes to understanding mortality and associated factors in MV patients, informing initiatives to improve critical care outcomes in Ethiopia. Competing Interests: Author conflict of interest statement: The authors declare that there is no conflict of interest regarding the publication of this article, "Prevalence of Mortality and Associated Factors Among ICU-Admitted Adult Patients with Mechanical Ventilation in Ethiopia: A Systematic Review and Meta-Analysis." The research was conducted objectively, and the authors have no financial or personal relationships that could influence or bias the findings and conclusions presented in this manuscript. This work was carried out with the sole purpose of contributing to the scientific understanding of mortality and associated factors in mechanically ventilated patients in Ethiopian ICUs. The authors report no conflicts of interest. (Copyright © 2024 by the Shock Society.) |
| References: | Zimmerman JE, Kramer AA, Knaus WA. Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012. Crit Care . 2013;17(2):R81. Walter K. Mechanical ventilation. JAMA . 2021;326(14):1452. Lassen H. A preliminary report on the 1952 poliomyelitis epidemic in. Classic Papers Crit Care . 1953;1(1). Ketcham SW, Sedhai YR, Miller HC, et al. Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study. Crit Care . 2020;24(1):391. Kelly FE, Fong K, Hirsch N, et al. Intensive care medicine is 60 years old: the history and future of the intensive care unit. Clin Med (Lond) . 2014;14(4):376–379. Metnitz PG, Metnitz B, Moreno RP, et al. Epidemiology of mechanical ventilation: analysis of the SAPS 3 database. Intensive Care Med . 2009;35(5):816–825. Klompas M. Complications of mechanical ventilation—the CDC’s new surveillance paradigm. N Engl J Med . 2013;368(16):1472–1475. Mutlu G, Factor P. Complications of mechanical ventilation. Respir Care Clin N Am . 2000;6(2):213–252, v. Perren A, Brochard L. Managing the apparent and hidden difficulties of weaning from mechanical ventilation. Intensive Care Med . 2013;39(11):1885–1895. Endeshaw AS, Tarekegn F, Bayu HT, et al. The magnitude of mortality and its determinants in Ethiopian adult intensive care units: a systematic review and meta-analysis. Ann Med Surg (Lond) . 2022;84:104810. Berhe E, Gebrehiwet TG, Teka H, et al. Clinical characteristics and determinants of invasive mechanical ventilation outcome in adult intensive care unit in northern Ethiopia: a resource-limited setting. J Pan Afr Thorac Soc . 2023;4(1):11–21. Kenubish D: Time to Death and its Predictors among Adult Patients On Mechanical Ventilation Admitted to Intensive Care Unit in West Amhara Comprehensive Specialized Hospitals. Amhara, Ethiopia: Retrospective Follow Up Study, 2022. Liang J, Li Z, Dong H, et al. Prognostic factors associated with mortality in mechanically ventilated patients in the intensive care unit: a single-center, retrospective cohort study of 905 patients. Medicine (Baltimore) . 2019;98(42):e17592. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg . 2021;88:105906. The EndNote Team: EndNote. 20th ed. Philadelphia: Clarivate Analytics, 2020. Institute JB, Institute JB. Checklist for Analytical Cross Sectional Studies. Adelaide: The Joanna Briggs Institute 2017;7. StataCorp: Stata 17.0. Texas USA: StataCorp LLC, 2021. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med . 2002;21(11):1539–1558. World Health Organization: World Report on Ageing and Health. World Health Organization, 2015. Nour TY, Farah AM, Ali OM, et al. Immunization coverage in Ethiopia among 12–23 month old children: systematic review and meta-analysis. BMC Public Health . 2020;20(1):1134. Biset G, Woday A, Mihret S, et al. Full immunization coverage and associated factors among children age 12-23 months in Ethiopia: systematic review and meta-analysis of observational studies. Hum Vaccin Immunother . 2021;17(7):2326–2335. Abate SM, Basu B, Jemal B, et al. Pattern of disease and determinants of mortality among ICU patients on mechanical ventilator in sub-Saharan Africa: a multilevel analysis. Crit Care . 2023;27(1):37. Debebe F, Goffi A, Haile T, et al. Predictors of ICU mortality among mechanically ventilated patients: an inception cohort study from a tertiary care center in Addis Ababa, Ethiopia. Crit Care Res Pract . 2022;2022:7797328. Alemayehu M, Azazh A, Hussien H, et al. Characteristics and outcomes of mechanically ventilated patients at adult ICU of selected public hospitals in Addis Ababa, Ethiopia. Open Access Emerg Med . 2022;14:395–404. Tsegay K, Teklu T, Debebe F, et al.: Outcomes of Patients on Mechanical Ventilation among Adult Intensive Care Units of Tikur Anbesa Specialized Hospital. Addis Ababa, Ethiopia: Research Square, 2023. Fialkow L, Farenzena M, Wawrzeniak IC, et al. Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil: an epidemiological study. Clinics . 2016;71:144–151. Combes A, Costa M-A, Trouillet J-L, et al. Morbidity, mortality, and quality-of-life outcomes of patients requiring ≥14 days of mechanical ventilation. Crit Care Med . 2003;31(5):1373–1381. Parker RK, Mwachiro EB, Mwachiro MM, et al. Mortality prediction in rural Kenya: a cohort study of mechanical ventilation in critically ill patients. Crit Care Explor . 2019;1(12):e0067. Meinders AJ, van der Hoeven JG, Meinders AE. The outcome of prolonged mechanical ventilation in elderly patients: are the efforts worthwhile? Age Ageing . 1996;25(5):353–356. Sudarsanam TD, Jeyaseelan L, Thomas K, et al. Predictors of mortality in mechanically ventilated patients. Postgrad Med J . 2005;81(962):780–783. Towey R, Ojara S. Practice of intensive care in rural Africa: an assessment of data from Northern Uganda. Afr Health Sci . 2008;8(1):61–64. Huang C. How prolonged mechanical ventilation is a neglected disease in chest medicine: a study of prolonged mechanical ventilation based on 6 years of experience in Taiwan. Ther Adv Respir Dis . 2019;13:1753466619878552. Easter BD, Fischer C, Fisher J. The use of mechanical ventilation in the ED. Am J Emerg Med . 2012;30(7):1183–1188. Hunegnaw W, Bayisa T: Outcome of mechanical ventilator use and associated factors at Saint Paul’s Hospital Millennium Medical College Medical Intensive Care Unit. MJH, 2022. |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240430 Latest Revision: 20240530 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1097/SHK.0000000000002340 |
| PMID: | 38662674 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1540-0514 |
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| DOI: | 10.1097/SHK.0000000000002340 |