دورية أكاديمية
Transcranial direct current stimulation (tDCS) for neurological disability among subacute stroke survivors to improve multiple domains in health-related quality of life: Randomized controlled trial protocol.
| العنوان: | Transcranial direct current stimulation (tDCS) for neurological disability among subacute stroke survivors to improve multiple domains in health-related quality of life: Randomized controlled trial protocol. |
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| المؤلفون: | Esht V; Physical Therapy Department, College of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia. Electronic address: vandanaesht@jazanu.edu.sa., Alshehri MM; Physical Therapy Department, College of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia., Balasubramanian K; Physical Therapy Department, College of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia., Sanjeevi RR; Physical Therapy Department, College of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia., Shaphe MA; Physical Therapy Department, College of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia., Alhowimel A; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin University, Jazan 45142, Kingdom of Saudi Arabia., Alenazi AM; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin University, Jazan 45142, Kingdom of Saudi Arabia., Alqahtani BA; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin University, Jazan 45142, Kingdom of Saudi Arabia., Alhwoaimel N; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin University, Jazan 45142, Kingdom of Saudi Arabia. |
| المصدر: | Neurophysiologie clinique = Clinical neurophysiology [Neurophysiol Clin] 2024 May; Vol. 54 (3), pp. 102976. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Clinical Trial Protocol; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: France NLM ID: 8804532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1769-7131 (Electronic) Linking ISSN: 09877053 NLM ISO Abbreviation: Neurophysiol Clin Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Elsevier Original Publication: Amsterdam ; New York : Elsevier, c1988- |
| مواضيع طبية MeSH: | Quality of Life* , Stroke*/complications , Stroke*/therapy , Stroke*/psychology , Stroke Rehabilitation*/methods , Transcranial Direct Current Stimulation*/methods, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Survivors/psychology ; Treatment Outcome ; Randomized Controlled Trials as Topic |
| مستخلص: | Objectives: The primary goal of the current proposal is to fill the gaps in the literature by studying the effectiveness of transcranial direct current stimulation (tDCS) on lifestyle parameters, and physical, behavioral, and cognitive functions among stroke survivors, and understanding the factors that mediate the effects of various domains related to Health-related Quality of life (HRQoL) improvements. Methods: Anticipated 64 volunteer subacute stroke survivors (>7 days to 3 months post stroke) aged 40-75 years with National Institutes of Health stroke scale (NIHSS) score of >10 and Mini-Mental State Examination (MMSE) score between 18 and 23 will be randomly assigned at a ratio of 1:1 to receive either: (1) 20 sessions of anodal tDCS or (2) sham tDCS in addition to conventional rehabilitation. Battery driven tDCS will be applied at 2 mA intensity to the dorsolateral prefrontal cortex and primary motor cortex for 20 minutes. The primary endpoints of study will be 36-Item Short Form Survey (SF-36) post intervention at 4 weeks. The secondary outcomes will include Stroke Specific Quality of Life Scale (SS_QOL), Montreal cognitive assessment (MCA), Beck Anxiety Inventory (BAI), Fugl-Meyer Assessment (FMA), 10 m walk test and Modified Barthel Activities of daily living (ADL) Index. At 0.05 level of significance, data normality, within group and between group actual differences will be analyzed with a moderate scope software. Discussion: Our knowledge of this technique and its use is expanding daily as tDCS motor recovery studies-mostly single-center studies-in either single session or many sessions have been completed and shown positive results. The field is prepared for a multi-center, carefully planned, sham-controlled, double-blinded tDCS study to comprehensively examine its feasibility and effectiveness in enhancing outcomes in stroke population. Conclusion: The function of Transcranial Direct Current Stimulation in aiding stroke recuperation will be ascertained. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. (Copyright © 2024 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Brain stimulation; Cognitive functions; Stroke rehabilitation; Subacute stroke; Transcranial direct current stimulation |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240523 Latest Revision: 20240711 |
| رمز التحديث: | 20240711 |
| DOI: | 10.1016/j.neucli.2024.102976 |
| PMID: | 38663043 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1769-7131 |
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| DOI: | 10.1016/j.neucli.2024.102976 |