دورية أكاديمية
Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery.
العنوان: | Prediction of drug-drug interaction risk of P-glycoprotein substrate in drug discovery. |
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المؤلفون: | Kido Y; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: yasuto.kido@shionogi.co.jp., Nanchi I; Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: isamu.nanchi@shionogi.co.jp., Matsuzaki T; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: takanobu.matsuzaki@shionogi.co.jp., Watari R; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: ryosuke.watari@shionogi.co.jp., Kiyohara H; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: hayato.kiyohara@shionogi.co.jp., Seki N; Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: naomi.seki@shionogi.co.jp., Okuda T; Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: tomohiko.okuda@shionogi.co.jp. |
المصدر: | Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2024 Jun; Vol. 56, pp. 101008. Date of Electronic Publication: 2024 Mar 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 101164773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-0920 (Electronic) Linking ISSN: 13474367 NLM ISO Abbreviation: Drug Metab Pharmacokinet Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : London : Elsevier Original Publication: Tokyo, Japan : Japanese Society for the Study of Xenobiotics, c2002- |
مواضيع طبية MeSH: | Drug Interactions* , ATP Binding Cassette Transporter, Subfamily B, Member 1*/metabolism , ATP Binding Cassette Transporter, Subfamily B, Member 1*/genetics , Drug Discovery*/methods , Mice, Knockout*, Animals ; Mice ; LLC-PK1 Cells ; Humans ; Swine ; Area Under Curve ; Male ; Pharmaceutical Preparations/metabolism |
مستخلص: | We aimed at predicting the drug-drug interaction (DDI) risk of P-glycoprotein (P-gp) substrates by using P-gp expressing LLC-PK1 cells and its knockout mice (KO). The area under the curve (AUC) of 16 marketed drugs and plasma concentration (C Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2024 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.) |
فهرسة مساهمة: | Keywords: Drug discovery; Drug-drug interaction; Knockout mice; P-glycoprotein; Permeability; Prediction; Substrate |
المشرفين على المادة: | 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1) 0 (Pharmaceutical Preparations) |
تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240622 Latest Revision: 20240711 |
رمز التحديث: | 20240711 |
DOI: | 10.1016/j.dmpk.2024.101008 |
PMID: | 38663183 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1880-0920 |
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DOI: | 10.1016/j.dmpk.2024.101008 |