دورية أكاديمية
Exploring the antifungal potential of Annona muricata leaf extract-loaded hydrogel in treating vulvovaginal candidiasis.
| العنوان: | Exploring the antifungal potential of Annona muricata leaf extract-loaded hydrogel in treating vulvovaginal candidiasis. |
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| المؤلفون: | Campos LM; Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., de Oliveira Lemos AS; Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., de Lima Paula P; Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., da Rocha VN; Department of Veterinary Medicine, Faculty of Medicine, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., de Freitas Araújo MG; Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, MG, Brazil., Tavares GD; Laboratory of Nanostructured Systems Development, Department of Pharmaceutical Science, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., Barradas TN; Laboratory of Nanostructured Systems Development, Department of Pharmaceutical Science, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., Nascimento WWG; Department of Pharmacy, Institute of Life Sciences, Federal University of Juiz de Fora, Campus Governador Valadares, Governor Valadares, MG, Brazil., Denadai AML; Department of Pharmacy, Institute of Life Sciences, Federal University of Juiz de Fora, Campus Governador Valadares, Governor Valadares, MG, Brazil., de Oliveira LFC; Center for Spectroscopy and Molecular Structure, Department of Chemistry, Institute of Exact Sciences, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil., Fabri RL; Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Juiz de Fora, MG, Brazil. Electronic address: rodrigo.fabri@ufjf.br. |
| المصدر: | Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Jun; Vol. 238, pp. 113919. Date of Electronic Publication: 2024 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c1993- |
| مواضيع طبية MeSH: | Annona*/chemistry , Candidiasis, Vulvovaginal*/drug therapy , Candidiasis, Vulvovaginal*/microbiology , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Leaves*/chemistry , Hydrogels*/chemistry , Hydrogels*/pharmacology , Candida albicans*/drug effects, Female ; Animals ; Rheology ; Microbial Sensitivity Tests ; Mice |
| مستخلص: | Vulvovaginal candidiasis, mostly caused by Candida albicans, remains a prevalent concern in women's health. Annona muricata L. (Annonaceae), a plant native from Brazil, is well-known for its therapeutic potential, including antitumor, anti-inflammatory, and antimicrobial properties. This study presents an innovative hydrogel formulation containing the ethanolic extract from A. muricata leaves designed to control C. albicans in an in vivo model of vulvovaginal candidiasis. Here, we report the development, thermal, physicochemical and rheological characterization of a Carbopol®-based hydrogel containing A. muricata extract. Furthermore, we evaluated its activity in a vulvovaginal candidiasis in vivo model. Thermal analyses indicated that the addition of the extract increased the polymer-polymer and polymer-solvent interactions.Rheological analysis showed a decrease in the viscosity and elasticity of the formulation as the A. muricata extract concentration increased, suggesting a liquid-like behavior. After treatment with the Carbopol®-based hydrogel with A. muricata, our in vivo results showed a significant reduction in vulvovaginal fungal burden and infection, as well as a reduction in mucosal inflammation. The current research opens up possibilities for the application of the Carbopol®-based hydrogel with A. muricata as a natural therapeutic option for the treatment of vulvovaginal candidiasis. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Annona muricata; Carbopol®-based hydrogel; Rheology characterization; Vulvovaginal candidiasis |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Plant Extracts) 0 (Hydrogels) |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240509 Latest Revision: 20240509 |
| رمز التحديث: | 20240510 |
| DOI: | 10.1016/j.colsurfb.2024.113919 |
| PMID: | 38663311 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4367 |
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| DOI: | 10.1016/j.colsurfb.2024.113919 |