دورية أكاديمية
Population-level immunologic variation in wild threespine stickleback (Gasterosteusaculeatus).
| العنوان: | Population-level immunologic variation in wild threespine stickleback (Gasterosteusaculeatus). |
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| المؤلفون: | Wohlleben AM; Institute of Zoology and Evolutionary Research, Friedrich Schiller University Jena, Jena, Germany; Biology Department, Clark University, Worcester, MA, USA. Electronic address: awohlleben@gmx.com., Tabima JF; Biology Department, Clark University, Worcester, MA, USA., Meyer NP; Biology Department, Clark University, Worcester, MA, USA., Steinel NC; Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, USA; Center for Pathogen Research and Training, University of Massachusetts Lowell, Lowell, MA, USA. |
| المصدر: | Fish & shellfish immunology [Fish Shellfish Immunol] 2024 Jun; Vol. 149, pp. 109580. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London ; New York : Academic Press, c1991- |
| مواضيع طبية MeSH: | Smegmamorpha*/immunology , Smegmamorpha*/genetics , Smegmamorpha*/parasitology , Fish Diseases*/immunology , Fish Diseases*/parasitology , Cestode Infections*/veterinary , Cestode Infections*/immunology , Cestode Infections*/parasitology , Cestoda*/immunology , Cestoda*/physiology, Animals ; Host-Parasite Interactions/immunology ; Alaska ; Immunity, Innate/genetics |
| مستخلص: | Wild organisms are regularly exposed to a wide range of parasites, requiring the management of an effective immune response while avoiding immunopathology. Currently, our knowledge of immunoparasitology primarily derives from controlled laboratory studies, neglecting the genetic and environmental diversity that contribute to immune phenotypes observed in wild populations. To gain insight into the immunologic variability in natural settings, we examined differences in immune gene expression of two Alaskan stickleback (Gasterosteus aculeatus) populations with varying susceptibility to infection by the cestode Schistocephalus solidus. Between these two populations, we found distinct immune gene expression patterns at the population level in response to infection with fish from the high-infection population displaying signs of parasite-driven immune manipulation. Further, we found significant differences in baseline immune gene profiles between the populations, with uninfected low-infection population fish showing signatures of inflammation compared to uninfected high-infection population fish. These results shed light on divergent responses of wild populations to the same parasite, providing valuable insights into host-parasite interactions in natural ecosystems. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| معلومات مُعتمدة: | R01 AI146168 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240519 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.fsi.2024.109580 |
| PMID: | 38663464 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9947 |
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| DOI: | 10.1016/j.fsi.2024.109580 |