دورية أكاديمية
The effect of unloading and ejection conditions on the properties of pharmaceutical tablets.
| العنوان: | The effect of unloading and ejection conditions on the properties of pharmaceutical tablets. |
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| المؤلفون: | Mazel V; Univ. Bordeaux, CNRS, Arts et Metiers Institute of Technology, Bordeaux INP, INRAE, I2M Bordeaux, F-33400 Talence, France., Yost E; Synthetic Molecule Pharmaceutics, Research and Early Development (gRED), Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sluga KK; Synthetic Molecule Pharmaceutics, Research and Early Development (gRED), Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Nagapudi K; Synthetic Molecule Pharmaceutics, Research and Early Development (gRED), Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Muliadi AR; Synthetic Molecule Pharmaceutics, Research and Early Development (gRED), Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: muliadi.ariel@gene.com. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2024 Jun 10; Vol. 658, pp. 124150. Date of Electronic Publication: 2024 Apr 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Tablets* , Tensile Strength* , Cellulose*/chemistry , Lactose*/chemistry , Mannitol*/chemistry , Excipients*/chemistry, Technology, Pharmaceutical/methods ; Pressure ; Drug Compounding/methods ; Chemistry, Pharmaceutical/methods |
| مستخلص: | This study investigates decompression and ejection conditions on tablet characteristics by comparing compact densities and tensile strengths made using regular rigid dies and custom-built die systems that enable triaxial decompression. Die-wall pressure evolution during decompression and ejection stresses did not meaningfully impact the density and tensile strength of the materials tested: microcrystalline cellulose, crystalline lactose monohydrate, and mannitol. Furthermore, the apparent differences in tensile strength between rectangular cuboids and cylindrical compacts are unrelated to decompression and ejection conditions, but rather a consequence of their shapes and of the test configurations. This suggests that elastic and plastic deformations that may occur during decompression and ejection are not significantly influenced by die-wall pressure evolution. We thus conclude that while triaxial decompression and constraint-free ejection may allow the production of defect-free compacts for materials that otherwise are defect prone using a rigid die, they seem to pose no benefits when the materials already produce defect-free compacts using a rigid die. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Mechanical properties; Pharmaceutical powder; Powder compaction; Tableting; Tensile strength; Triaxial decompression |
| المشرفين على المادة: | 0 (Tablets) 9004-34-6 (Cellulose) OP1R32D61U (microcrystalline cellulose) J2B2A4N98G (Lactose) 3OWL53L36A (Mannitol) 0 (Excipients) |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240530 Latest Revision: 20240530 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1016/j.ijpharm.2024.124150 |
| PMID: | 38663645 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2024.124150 |