دورية أكاديمية
Superb bio-effectiveness of Cobalt (II) phthalocyanine and Ag NPs adorned Sm-doped ZnO nanorods/cuttlefish bone to annihilate Trichinella spiralis muscle larvae and adult worms: In-vitro evaluation.
| العنوان: | Superb bio-effectiveness of Cobalt (II) phthalocyanine and Ag NPs adorned Sm-doped ZnO nanorods/cuttlefish bone to annihilate Trichinella spiralis muscle larvae and adult worms: In-vitro evaluation. |
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| المؤلفون: | Bayaumy FEA; Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt. Electronic address: fatma.anwar@women.asu.edu.eg., Rizk SA; Department of Chemistry, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt., Darwish AS; Department of Chemistry, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt. |
| المصدر: | Parasitology international [Parasitol Int] 2024 Aug; Vol. 101, pp. 102899. Date of Electronic Publication: 2024 Apr 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9708549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0329 (Electronic) Linking ISSN: 13835769 NLM ISO Abbreviation: Parasitol Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c1997- |
| مواضيع طبية MeSH: | Zinc Oxide*/pharmacology , Indoles*/pharmacology , Trichinella spiralis*/drug effects , Nanotubes*/chemistry , Silver*/pharmacology , Larva*/drug effects , Organometallic Compounds*/pharmacology , Organometallic Compounds*/chemistry, Animals ; Metal Nanoparticles ; Decapodiformes/parasitology ; Anthelmintics/pharmacology ; Nanocomposites ; Bone and Bones/drug effects ; Bone and Bones/parasitology ; Muscles/parasitology ; Muscles/drug effects |
| مستخلص: | Herein, innovative biocides are designed for the treatment of Trichinella spiralis muscle larvae (ML) and adult worms. Samarium-doped ZnO nanorods (Sm-doped ZnO) are stabilized onto the laminar structure of cuttlefish bone (CB) matrix and adorned by either Ag NPs or cobalt phthalocyanine (CoPc) species. Physicochemical characteristics of such nanocomposites are scrutinised. Adorning of Sm-doped ZnO/CB with Ag NPs shortens rod-like shaped Sm-doped ZnO nanoparticles and accrues them, developing large-sized detached patches over CB moiety. Meanwhile, adorning of Sm-doped ZnO/CB by CoPc species degenerates CB lamellae forming semi-rounded platelets and encourages invading of Sm-doped ZnO nanorods deeply inside gallery spacings of CB. Both nanocomposites possess advanced parasiticidal activity, displaying quite intoxication for ML and adult worms (≥88% mortality) within an incubation period of <48 h at concentrations around 200 μg/ml. CoPc@Sm-doped ZnO/CB nanocomposite exhibits faster killing efficiency of adult worms than that of Ag@Sm-doped ZnO/CB at a concentration of ∼75 μg/ml showing entire destruction of parasite after 24 h incubation with the former nanocomposite and just 60% worm mortality after 36 h exposure to the later one. Morphological studies of the treated ML and adult worms show that CoPc@Sm-doped ZnO/CB exhibits a destructive impact on the parasite body, creating featureless and sloughed fragments enriched with intensive vacuoles. Hybridization of cuttlefish bone lamellae by CoPc species is considered a springboard for fabrication of futuristic aggressive drugs against various food- and water-borne parasites. Competing Interests: Declaration of competing interest The authors declare no competing interests. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antitrichinellosis; CoPc; Muscle larvae; Sm doped ZnO/CB nanocomposite; T. spiralis adult worms |
| المشرفين على المادة: | SOI2LOH54Z (Zinc Oxide) 0 (Indoles) 3M4G523W1G (Silver) 0 (Organometallic Compounds) 3317-67-7 (cobalt phthalocyanine) 0 (Anthelmintics) |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240524 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| DOI: | 10.1016/j.parint.2024.102899 |
| PMID: | 38663799 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-0329 |
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| DOI: | 10.1016/j.parint.2024.102899 |