دورية أكاديمية
Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study.
| العنوان: | Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study. |
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| المؤلفون: | Mahey R; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India. reetamahey52@gmail.com., Rajput M; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Dada R; Deptt of Anatomy, All India Institute of Medical Sciences, New Delhi, India., Kalaivani M; Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India., Gupta M; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Cheluvaraju R; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Malhotra N; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Saini M; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Bhatt A; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Kumar M; Deptt of Anatomy, All India Institute of Medical Sciences, New Delhi, India., Singh N; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Bhatla N; Deptt of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India. |
| المصدر: | Journal of human genetics [J Hum Genet] 2024 Aug; Vol. 69 (8), pp. 365-372. Date of Electronic Publication: 2024 Apr 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 9808008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-232X (Electronic) Linking ISSN: 14345161 NLM ISO Abbreviation: J Hum Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : London : Nature Pub. Group Original Publication: Tokyo : Springer-Verlag, c1998- |
| مواضيع طبية MeSH: | Infertility, Female*/genetics , Infertility, Female*/epidemiology , Receptors, FSH*/genetics, Adult ; Female ; Humans ; Pregnancy ; Fertilization in Vitro ; Genotype ; India/epidemiology ; Polymorphism, Single Nucleotide ; Prevalence ; Prospective Studies ; Reproductive Techniques, Assisted |
| مستخلص: | The present prospective cohort study evaluated the prevalence of FSH-R receptor Asn680Ser and Ala307Thr among infertile Indian women and the correlation of these polymorphisms with ART outcomes. Total 804 infertile and 209 fertile controls were enrolled for FSH-R analysis. Correlation of different genotypes with ovarian reserve markers, IVF parameters, and cumulative live birth rates (CLBR) was done among women undergoing IVF. In fertile controls, at 680 position GG (Ser/Ser) was the most common genotype; but among infertile women, all the genotypes were equally distributed. There was no significant difference in ovarian response parameters, oocyte yield, and CLBR among the three genotype groups. Empty follicle syndrome (EFS) was highest in women with AA or AG type at both positions. On categorisation of unexpected poor responders according to POSEIDON stratification; GG genotype at both positions had the lowest risk ratio of low-oocyte yield in ART cycles, but these differences were not statistically significant. This is the largest study from Indian ethnicity showing GG (Ser/Ser) genotype is most common among fertile women. The effect of FSH-R genotypes is very marginal on IVF parameters and is not reflected in CLBR. More prospective data may be required on the correlation of these genotypes with genuine EFS, thus stratifying the next cycles with self or donor oocytes. Routine genetic testing of FSH-R polymorphism should not be done except in a research setting. As both 680 and 307 positions are in linkage disequilibrium, only 680 position analysis may be done in a research setting. (© 2024. The Author(s), under exclusive licence to The Japan Society of Human Genetics.) |
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| المشرفين على المادة: | 0 (FSHR protein, human) 0 (Receptors, FSH) |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240725 Latest Revision: 20240726 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1038/s10038-024-01251-8 |
| PMID: | 38664537 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1435-232X |
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| DOI: | 10.1038/s10038-024-01251-8 |