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Exploring the Impact of Cigarette Smoke Extracts on Vitamin B 12 : Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation.

التفاصيل البيبلوغرافية
العنوان: Exploring the Impact of Cigarette Smoke Extracts on Vitamin B 12 : Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation.
المؤلفون: Al Zoubi MS; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 211-63, Jordan., Al-Oun MA; Department of Biological Sciences, Faculty of Sciences, Yarmouk University, Irbid 211-63, Jordan., Abusahyoun FY; Department of Biological Sciences, Faculty of Sciences, Yarmouk University, Irbid 211-63, Jordan., Abualarja MI; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 211-63, Jordan., Al Smadi A; Department of Biological Sciences, Faculty of Sciences, Yarmouk University, Irbid 211-63, Jordan., Al-Trad B; Department of Biological Sciences, Faculty of Sciences, Yarmouk University, Irbid 211-63, Jordan., Awadin SA; Department of Biological Sciences, Faculty of Sciences, Yarmouk University, Irbid 211-63, Jordan., Al-Batayneh K; Department of Biological Sciences, Faculty of Sciences, Yarmouk University, Irbid 211-63, Jordan., Elaarag M; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar., Al-Zoubi RM; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.; Department of Chemistry, Jordan University of Science and Technology, Irbid 22110, Jordan.; Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha 2713, Qatar.
المصدر: Biochemistry research international [Biochem Res Int] 2024 Apr 18; Vol. 2024, pp. 8827402. Date of Electronic Publication: 2024 Apr 18 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101546751 Publication Model: eCollection Cited Medium: Print ISSN: 2090-2247 (Print) NLM ISO Abbreviation: Biochem Res Int Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Corp.
مستخلص: Vitamin B 12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B 12 exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). This study aimed to evaluate the effect of cigarette smoke on the chemical structure of methylcobalamin and hydroxycobalamin forms of vitamin B 12 . MeCbl and OHCbl were markedly affected by exposure to cigarette smoke. The resemblance of the Rt between MeCbl and OHCbl and CNCbl indicates that exposure to cigarette smoke extracts chemically alters MeCbl and OHCbl to CNCbl, warranting in vivo research investigations.
Competing Interests: All authors declare that there are no conflicts of interest.
(Copyright © 2024 Mazhar Salim Al Zoubi et al.)
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تواريخ الأحداث: Date Created: 20240426 Latest Revision: 20240427
رمز التحديث: 20240427
مُعرف محوري في PubMed: PMC11045288
DOI: 10.1155/2024/8827402
PMID: 38665151
قاعدة البيانات: MEDLINE
الوصف
تدمد:2090-2247
DOI:10.1155/2024/8827402