The impact of enriched environments on cerebral oxidative balance in rodents: a systematic review of environmental variability effects.
| العنوان: | The impact of enriched environments on cerebral oxidative balance in rodents: a systematic review of environmental variability effects. |
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| المؤلفون: | Ramos TL; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., de Sousa Fernandes MS; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.; Instituto Keizo Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., da Silva Fidélis DE; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Jurema Santos GC; Programa de Pós-Graduação em Nutrição, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Albuquerque RB; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.; Instituto Keizo Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Ferreira DJS; Physical Education Department/Federal University of São Francisco Valley, Petrolina, Pernambuco, Brazil., de Souza RF; Department of Physical Education, Federal University of Sergipe, São Cristovão, Sergipe, Brazil., Badicu G; Department of Physical Education and Special Motricity, Transilvania University of Braşov, Braşov, Romania., Yagin FH; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, Malatya, Türkiye., Yagin B; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, Malatya, Türkiye., Alwhaibi RM; Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Souto FO; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.; Instituto Keizo Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Lagranha CJ; Programa de Pós-Graduação em Nutrição Atividade Física e Plasticidade Fenotípica, Centro Acadêmico de Vitória, Vitória de Santo Antão, Pernambuco, Brazil. |
| المصدر: | Frontiers in neuroscience [Front Neurosci] 2024 Apr 11; Vol. 18, pp. 1366747. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024). |
| نوع المنشور: | Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
| مستخلص: | Introduction: The present review aimed to systematically summarize the impacts of environmental enrichment (EE) on cerebral oxidative balance in rodents exposed to normal and unfavorable environmental conditions. Methods: In this systematic review, four databases were used: PubMed (830 articles), Scopus (126 articles), Embase (127 articles), and Science Direct (794 articles). Eligibility criteria were applied based on the Population, Intervention, Comparison, Outcomes, and Study (PICOS) strategy to reduce the risk of bias. The searches were carried out by two independent researchers; in case of disagreement, a third participant was requested. After the selection and inclusion of articles, data related to sample characteristics and the EE protocol (time of exposure to EE, number of animals, and size of the environment) were extracted, as well as data related to brain tissues and biomarkers of oxidative balance, including carbonyls, malondialdehyde, nitrotyrosine, oxygen-reactive species, and glutathione (reduced/oxidized). Results: A total of 1,877 articles were found in the four databases, of which 16 studies were included in this systematic review. The results showed that different EE protocols were able to produce a global increase in antioxidant capacity, both enzymatic and non-enzymatic, which are the main factors for the neuroprotective effects in the central nervous system (CNS) subjected to unfavorable conditions. Furthermore, it was possible to notice a slowdown in neural dysfunction associated with oxidative damage, especially in the prefrontal structure in mice. Discussion: In conclusion, EE protocols were determined to be valid tools for improving oxidative balance in the CNS. The global decrease in oxidative stress biomarkers indicates refinement in reactive oxygen species detoxification, triggering an improvement in the antioxidant network. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Ramos, de Sousa Fernandes, da Silva Fidélis, Jurema Santos, Albuquerque, Ferreira, de Souza, Badicu, Yagin, Yagin, Alwhaibi, Souto and Lagranha.) |
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| فهرسة مساهمة: | Keywords: antioxidants; biochemistry; brain; central nervous system; enriched environment; oxidative stress |
| تواريخ الأحداث: | Date Created: 20240426 Latest Revision: 20240427 |
| رمز التحديث: | 20240427 |
| مُعرف محوري في PubMed: | PMC11043487 |
| DOI: | 10.3389/fnins.2024.1366747 |
| PMID: | 38665291 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1662-4548 |
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| DOI: | 10.3389/fnins.2024.1366747 |