دورية أكاديمية
Copaiba oil minimizes inflammation and promotes parenchyma re-epithelization in acute allergic asthma model induced by ovalbumin in BALB/c mice.
| العنوان: | Copaiba oil minimizes inflammation and promotes parenchyma re-epithelization in acute allergic asthma model induced by ovalbumin in BALB/c mice. |
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| المؤلفون: | Caputo LS; Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Alves CL; Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Laranjeira IM; Life and Health Sciences Research Institute, ICVS, School of Medicine, Campus of Gualtar, University of Minho, Braga, Portugal.; ICVS/3B‟s - PT Government Associate Laboratory, Braga, Portugal.; Centre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.; Centre of Molecular and Environmental Biology, CBMA, University of Minho, Campus de Gualtar, Braga, Portugal., Fonseca-Rodrigues D; Life and Health Sciences Research Institute, ICVS, School of Medicine, Campus of Gualtar, University of Minho, Braga, Portugal.; ICVS/3B‟s - PT Government Associate Laboratory, Braga, Portugal., da Silva Filho AA; Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Dias ACP; Centre of Molecular and Environmental Biology, CBMA, University of Minho, Campus de Gualtar, Braga, Portugal., Pinto-Ribeiro F; Life and Health Sciences Research Institute, ICVS, School of Medicine, Campus of Gualtar, University of Minho, Braga, Portugal.; ICVS/3B‟s - PT Government Associate Laboratory, Braga, Portugal., Pereira Junior ODS; Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., de Paula ACC; Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Nagato AC; Department of Physiology, Federal University of Juiz de Fora, UFJF, Juiz de Fora, Brazil., Corrêa JODA; Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil. |
| المصدر: | Frontiers in pharmacology [Front Pharmacol] 2024 Apr 11; Vol. 15, pp. 1356598. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Media] |
| مستخلص: | Introduction: Asthma is a condition of airflow limitation, common throughout the world, with high mortality rates, especially as it still faces some obstacles in its management. As it constitutes a public health challenge, this study aimed to investigate the effect of copaiba oil (e.g., Copaifera langsdorffii ), as a treatment resource, at doses of 50 and 100 mg/kg on certain mediators of acute lung inflammation (IL-33, GATA3, FOXP3, STAT3, and TBET) and early mechanisms of lung remodeling (degradation of elastic fiber tissues, collagen deposition, and goblet cell hyperplasia). Methods: Using an ovalbumin-induced acute allergic asthma model in BALB/c mice, we analyzed the inflammatory mediators through immunohistochemistry and the mechanisms of lung remodeling through histopathology, employing orcein, Masson's trichrome, and periodic acid-Schiff staining. Results: Copaiba oil treatment (CO) reduced IL-33 and increased FOXP3 by stimulating the FOXP3/GATA3 and FOXP3/STAT3 pathways. Additionally, it upregulated TBET, suggesting an additional role in controlling GATA3 activity. In the respiratory epithelium, CO decreased the fragmentation of elastic fibers while increasing the deposition of collagen fibers, favoring epithelial restructuring. Simultaneously, CO reduced goblet cell hyperplasia. Discussion: Although additional research is warranted, the demonstrated anti-inflammatory and re-epithelializing action makes CO a viable option in exploring new treatments for acute allergic asthma. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Caputo, Alves, Laranjeira, Fonseca-Rodrigues, da Silva Filho, Dias, Pinto-Ribeiro, Pereira Junior, de Paula, Nagato and Corrêa.) |
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| فهرسة مساهمة: | Keywords: Copaifera langsdorffii Desf; airway remodeling; anti-inflammatory agent; asthma; lung inflammation; natural products; re-epithelialization |
| تواريخ الأحداث: | Date Created: 20240426 Latest Revision: 20240427 |
| رمز التحديث: | 20240427 |
| مُعرف محوري في PubMed: | PMC11043548 |
| DOI: | 10.3389/fphar.2024.1356598 |
| PMID: | 38666018 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1663-9812 |
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| DOI: | 10.3389/fphar.2024.1356598 |