دورية أكاديمية
Exosomes in Vascular/Neurological Disorders and the Road Ahead.
| العنوان: | Exosomes in Vascular/Neurological Disorders and the Road Ahead. |
|---|---|
| المؤلفون: | Alzahrani FA; Department of Biochemistry, King Fahad Center for Medical Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Riza YM; Department of Biochemistry, King Fahad Center for Medical Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Eid TM; Department of Biochemistry, King Fahad Center for Medical Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Almotairi R; Department of Medical Laboratory Technology, Prince Fahad bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia., Scherschinski L; Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Contreras J; Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Nadeem M; Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Perez SE; Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Raikwar SP; Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Jha RM; Department of Neurology, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Preul MC; Department of Neurosurgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Ducruet AF; Department of Neurosurgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Lawton MT; Department of Neurosurgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Bhatia K; School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA., Akhter N; Department of Biology, Arizona State University, Lake Havasu City, AZ 86403, USA., Ahmad S; Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.; Department of Neurosurgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.; Phoenix Veterans Affairs (VA) Health Care System, Phoenix, AZ 85012, USA. |
| المصدر: | Cells [Cells] 2024 Apr 12; Vol. 13 (8). Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | Exosomes*/metabolism, Humans ; Animals ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Vascular Diseases/metabolism ; Vascular Diseases/pathology ; Nervous System Diseases/metabolism ; Nervous System Diseases/pathology |
| مستخلص: | Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke, and aneurysms, are characterized by the abnormal accumulation and aggregation of disease-causing proteins in the brain and spinal cord. Recent research suggests that proteins linked to these conditions can be secreted and transferred among cells using exosomes. The transmission of abnormal protein buildup and the gradual degeneration in the brains of impacted individuals might be supported by these exosomes. Furthermore, it has been reported that neuroprotective functions can also be attributed to exosomes in neurodegenerative diseases. The potential neuroprotective functions may play a role in preventing the formation of aggregates and abnormal accumulation of proteins associated with the disease. The present review summarizes the roles of exosomes in neurodegenerative diseases as well as elucidating their therapeutic potential in AD, PD, ALS, HD, stroke, and aneurysms. By elucidating these two aspects of exosomes, valuable insights into potential therapeutic targets for treating neurodegenerative diseases may be provided. |
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| فهرسة مساهمة: | Keywords: Alzheimer’s; exosomes; neurological diseases; stroke; vascular diseases |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240426 Latest Revision: 20240515 |
| رمز التحديث: | 20240516 |
| مُعرف محوري في PubMed: | PMC11049650 |
| DOI: | 10.3390/cells13080670 |
| PMID: | 38667285 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2073-4409 |
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| DOI: | 10.3390/cells13080670 |