دورية أكاديمية
أعرض في EDS

Somatic Mutations in Surgically Treated Colorectal Liver Metastases: An Overview.

التفاصيل البيبلوغرافية
العنوان: Somatic Mutations in Surgically Treated Colorectal Liver Metastases: An Overview.
المؤلفون: Wang J; Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Botvinov J; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Bhatt AJ; University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA., Beyer K; Department of General and Visceral Surgery, Charité Campus Benjamin Franklin, 12203 Berlin, Germany., Kreis ME; Department of General and Visceral Surgery, Charité Campus Benjamin Franklin, 12203 Berlin, Germany., Adam M; Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Alseidi A; Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Margonis GA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
المصدر: Cells [Cells] 2024 Apr 14; Vol. 13 (8). Date of Electronic Publication: 2024 Apr 14.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Liver Neoplasms*/secondary , Liver Neoplasms*/surgery , Mutation*/genetics, Humans ; DNA Mismatch Repair/genetics ; Precision Medicine
مستخلص: Colorectal cancer is the second most common cause of cancer death in the United States, and up to half of patients develop colorectal liver metastases (CRLMs). Notably, somatic genetic mutations, such as mutations in RAS , BRAF , mismatch repair (MMR) genes, TP53 , and SMAD4 , have been shown to play a prognostic role in patients with CRLM. This review summarizes and appraises the current literature regarding the most relevant somatic mutations in surgically treated CRLM by not only reviewing representative studies, but also providing recommendations for areas of future research. In addition, advancements in genetic testing and an increasing emphasis on precision medicine have led to a more nuanced understanding of these mutations; thus, more granular data for each mutation are reviewed when available. Importantly, such knowledge can pave the way for precision medicine with the ultimate goal of improving patient outcomes.
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معلومات مُعتمدة: P30 CA008748 United States CA NCI NIH HHS; N/A Jane Wang was supported by the UCSF Noyce Initiative Computational Innovator Postdoctoral Fellowship Award.
فهرسة مساهمة: Keywords: BRAF; CRLM; RAS; somatic mutations
تواريخ الأحداث: Date Created: 20240426 Date Completed: 20240426 Latest Revision: 20240709
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC11049420
DOI: 10.3390/cells13080679
PMID: 38667294
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells13080679