دورية أكاديمية
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Clinical Strains of Mycobacterium tuberculosis Representing Different Genotype Families Exhibit Distinct Propensities to Adopt the Differentially Culturable State.

التفاصيل البيبلوغرافية
العنوان: Clinical Strains of Mycobacterium tuberculosis Representing Different Genotype Families Exhibit Distinct Propensities to Adopt the Differentially Culturable State.
المؤلفون: Gordhan BG; Department of Science and Innovation and the National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2017, South Africa.; National Health Laboratory Service, Johannesburg 2000, South Africa., Padarath K; Department of Science and Innovation and the National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2017, South Africa.; National Health Laboratory Service, Johannesburg 2000, South Africa., Sewcharran A; Department of Science and Innovation and the National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2017, South Africa.; National Health Laboratory Service, Johannesburg 2000, South Africa., McIvor A; Department of Science and Innovation and the National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2017, South Africa.; National Health Laboratory Service, Johannesburg 2000, South Africa., VanNieuwenhze MS; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47405-7000, USA., Waja Z; Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg 2017, South Africa., Martinson N; Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg 2017, South Africa.; Center for TB Research, Johns Hopkins University, Baltimore, MD 21218, USA., Kana BD; Department of Science and Innovation and the National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2017, South Africa.; National Health Laboratory Service, Johannesburg 2000, South Africa.
المصدر: Pathogens (Basel, Switzerland) [Pathogens] 2024 Apr 12; Vol. 13 (4). Date of Electronic Publication: 2024 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: Growing evidence points to the presence of differentially culturable tubercle bacteria (DCTB) in clinical specimens from individuals with active tuberculosis (TB) disease. These bacteria are unable to grow on solid media but can resuscitate in liquid media. Given the epidemiological success of certain clinical genotype families of Mycobacterium tuberculosis , we hypothesize that different strains may have distinct mechanisms of adaptation and tolerance. We used an in vitro carbon starvation model to determine the propensity of strains from lineages 2 and 4 that included the Beijing and LAM families respectively, to generate DCTB. Beijing strains were associated with a greater propensity to produce DCTB compared to LAM strains. Furthermore, LAM strains required culture filtrate (CF) for resuscitation whilst starved Beijing strains were not dependent on CF. Moreover, Beijing strains showed improved resuscitation with cognate CF, suggesting the presence of unique growth stimulatory molecules in this family. Analysis of starved Beijing and LAM strains showed longer cells, which with resuscitation were restored to a shorter length. Cell wall staining with fluorescent D-amino acids identified strain-specific incorporation patterns, indicating that cell surface remodeling during resuscitation was distinct between clinical strains. Collectively, our data demonstrate that M. tuberculosis clinical strains from different genotype lineages have differential propensities to generate DCTB, which may have implications for TB treatment success.
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معلومات مُعتمدة: HHMI000 United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: Beijing strains; LAM strains; Mycobacterium tuberculosis; differentially culturable tubercle bacteria; tuberculosis
تواريخ الأحداث: Date Created: 20240426 Latest Revision: 20240429
رمز التحديث: 20240429
مُعرف محوري في PubMed: PMC11054447
DOI: 10.3390/pathogens13040318
PMID: 38668273
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-0817
DOI:10.3390/pathogens13040318