دورية أكاديمية
Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis.
| العنوان: | Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis. |
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| المؤلفون: | Aguiar BRL; Health Science Graduate Program, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil., Ferreira EB; Health Science Graduate Program, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.; Nursing Department, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil., Normando AGC; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, São Paulo, Brazil., Dias SDS; Superior School of Health Sciences, Brasília, DF, Brazil., Guerra ENS; Laboratory of Oral Histopathology, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil., Reis PED; Nursing Department, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil. pauladiniz@unb.br.; School of Health Sciences, Campus Darcy Ribeiro, Asa Norte, University of Brasilia, 70910-900, Brasília, DF, Brazil. pauladiniz@unb.br. |
| المصدر: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2024 Jul; Vol. 200 (7), pp. 568-582. Date of Electronic Publication: 2024 Apr 26. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Urban & Vogel Country of Publication: Germany NLM ID: 8603469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-099X (Electronic) Linking ISSN: 01797158 NLM ISO Abbreviation: Strahlenther Onkol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [München] : Urban & Vogel, [c1986- |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide* , Radiodermatitis*/genetics, Humans ; Genetic Markers/genetics ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/genetics ; Risk Factors |
| مستخلص: | Purpose: To identify potential Single Nucleotide Polymorphisms (SNPs) of susceptibility for the development of acute radiation dermatitis in head and neck cancer patients, and also to verify the association between SNPs and the severity of RD. Methods: This systematic review was reported according to the PRISMA guideline. The proportion meta-analysis was performed to identify the prevalence of genetic markers by geographical region and radiation dermatitis severity. The meta-analysis was performed to verify the association between genetic markers and RD severity. The certainty of the evidence was assessed by GRADE. Results: Thirteen studies were included. The most prevalent SNPs were XRCC3 (rs861639) (36%), TGFβ1 (rs1800469) (35%), and RAD51 (rs1801321) (34%). There are prevalence studies in Europe and Asia, with a similar prevalence for all SNPs (29-40%). The prevalence was higher in patients who developed radiation dermatitis ≤2 for any subtype of genes (75-76%). No SNP showed a statistically significant association with very low certainty of evidence. Conclusion: The most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions. (© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Genetic markers; Head and neck neoplasms.; Radiodermatitis; Radiotherapy; Single Nucleotide Polymorphism |
| المشرفين على المادة: | 0 (Genetic Markers) |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240619 Latest Revision: 20240620 |
| رمز التحديث: | 20240621 |
| DOI: | 10.1007/s00066-024-02237-3 |
| PMID: | 38668865 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00066-024-02237-3 |