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Anti-Sporothrix Activity of Novel Copper-Itraconazole Complexes.

التفاصيل البيبلوغرافية
العنوان: Anti-Sporothrix Activity of Novel Copper-Itraconazole Complexes.
المؤلفون: de Azevedo-França JA; Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brasil., Borba-Santos LP; Laboratório de Biologia Celular de Fungos, Centro de Pesquisa em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil., de Matos LMC; Laboratório de Inovação Farmacêutica e Tecnológica, Departamento de Genética e Biologia Molecular, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brasil., Galvão BVD; Laboratório de Mutagênese Ambiental, Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Araujo-Lima CF; Laboratório de Inovação Farmacêutica e Tecnológica, Departamento de Genética e Biologia Molecular, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brasil., Felzenszwalb I; Laboratório de Mutagênese Ambiental, Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., de Souza W; Laboratório de Ultraestrutura Celular Hertha Meyer, Centro de Pesquisa em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil., Horn A Jr; Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil., Neves ES; Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil., Rozental S; Laboratório de Biologia Celular de Fungos, Centro de Pesquisa em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil., Navarro M; Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brasil.
المصدر: ChemMedChem [ChemMedChem] 2024 Aug 01; Vol. 19 (15), pp. e202400054. Date of Electronic Publication: 2024 Jul 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2006-
مواضيع طبية MeSH: Copper*/chemistry , Copper*/pharmacology , Itraconazole*/pharmacology , Itraconazole*/chemistry , Sporothrix*/drug effects , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Microbial Sensitivity Tests*, Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug
مستخلص: A series of new metal complexes, [Cu(ITZ) 2 Cl 2 ] ⋅ 5H 2 O (1) , [Cu(NO 3 ) 2 (ITZ) 2 ] ⋅ 3H 2 O ⋅ C 4 H 10 O (2) and [Cu(ITZ) 2 )(PPh 3 ) 2 ]NO 3  ⋅ 5H 2 O (3) were synthesized by a reaction of itraconazole (ITZ) with the respective copper salts under reflux. The metal complexes were characterized by elemental analyses, molar conductivity, 1 H and 13 C{ 1 H} nuclear magnetic resonance, UV-Vis, infrared and EPR spectroscopies. The antifungal activity of these metal complexes was evaluated against the main sporotrichosis agents: Sporothrix brasiliensis, Sporothrix schenkii, and Sporothrix globosa. All three new compounds inhibited the growth of S. brasiliensis and S. schenckii at lower concentrations than the free azole, with complex 2 able to kill all species at 4 μM and induce more pronounced alterations in fungal cells. Complexes 2 and 3 exhibited higher selectivity and no mutagenic effect at the concentration that inhibited fungal growth and affected fungal cells. The strategy of coordinating itraconazole (ITZ) to copper was successful, since the corresponding metal complexes were more effective than the parent drug. Particularly, the promising antifungal activity of the Cu-ITZ complexes makes them potential candidates for the development of an alternative drug to treat mycoses.
(© 2024 Wiley-VCH GmbH.)
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معلومات مُعتمدة: 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; APQ 01543/18 Fundação de Amparo à Pesquisa do Estado de Minas Gerais; 306358/2021-2 Conselho Nacional de Desenvolvimento Científico e Tecnológico; E-26/200.438/2023 Fundação de Amparo à Pesquisa do Estado da Bahia; 26/203.853/2022 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; E-592 26/200.839/2021 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; E-26/010.002119/2019 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
فهرسة مساهمة: Keywords: Copper complexes, Itraconazole; Sporothrix brasiliensis; Sporothrix globosa; Sporothrix schenckii
المشرفين على المادة: 789U1901C5 (Copper)
304NUG5GF4 (Itraconazole)
0 (Antifungal Agents)
0 (Coordination Complexes)
تواريخ الأحداث: Date Created: 20240426 Date Completed: 20240802 Latest Revision: 20240802
رمز التحديث: 20240802
DOI: 10.1002/cmdc.202400054
PMID: 38669597
قاعدة البيانات: MEDLINE
الوصف
تدمد:1860-7187
DOI:10.1002/cmdc.202400054