دورية أكاديمية
Electrospun EU/HPMC nanofibers decorated by ZIF-8 nanoparticle as the advanced electrochemical biosensor modifier for sensitive and selective detection of c-MET cancer biomarker in human plasma sample.
| العنوان: | Electrospun EU/HPMC nanofibers decorated by ZIF-8 nanoparticle as the advanced electrochemical biosensor modifier for sensitive and selective detection of c-MET cancer biomarker in human plasma sample. |
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| المؤلفون: | Maleki F; Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, 53714-161, Tabriz, Iran., Razmi H; Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, 53714-161, Tabriz, Iran. Electronic address: mh_razmi@yahoo.com., Rashidi MR; Pharmacy Faculty, Tabriz University of Medical Science, Tabriz, Iran., Yousefi M; Department of Immunology, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran., Ramezani S; Faculty of Textile Engineering, Urmia University of Technology, Urmia 5716693188, Iran., Ghorbani M; Iran Polymer and Petrochemical Institute, PO Box:14965/115, Tehran, Iran. Electronic address: ghorbani.marjan65@yahoo.com. |
| المصدر: | Biosensors & bioelectronics [Biosens Bioelectron] 2024 Aug 01; Vol. 257, pp. 116319. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Advanced Technology Original Publication: [Barking, Essex, England] : Elsevier Applied Science, 1989- |
| مواضيع طبية MeSH: | Biomarkers, Tumor*/blood , Biosensing Techniques*/methods , Electrochemical Techniques*/methods , Nanofibers*/chemistry , Proto-Oncogene Proteins c-met*/blood, Humans ; Imidazoles ; Limit of Detection ; Metal-Organic Frameworks/chemistry ; Nanoparticles/chemistry ; Neoplasms/blood ; Zeolites/chemistry |
| مستخلص: | This research presents a selective and sensitive electrochemical biosensor for the detection of the mesenchymal-epithelial transition factor (c-MET). The biosensing is based on a modification of the SPCE (screen-printed carbon electrode) with the electrospun nanofiber containing eudragit (EU), hydroxypropyl methylcellulose (HPMC), and Zeolite imidazolate frameworks (ZIF-8) nanoparticles. EU/HPMC/ZIF-8 nanofibers have presented a high capability of electron transfer, and more active surface area than bare SPCE due to synergistic effects between EU, HPMC, and ZIF-8. On the other hand, EU/HPMC nanofibers provided high porosity, flexible structures, high specific surface area, and good mechanical strength. The presence of ZIF-8 nanoparticles improved the immobilization of anti-c-MET on the modified SPCE and also resulted in increasing the conductivity. By c-MET incubation on the modified SPCE, c-MET was connected to anti-c-MET, and consequently the electrochemical signal of [Fe(CN) Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer biomarker; Electrochemical biosensor; Electrospun EU/HPMC/ZIF-8 nanofiber; Mesenchymal–epithelial transition factor (c-MET); Monoclonal antibody; Screen-printed carbon electrode |
| المشرفين على المادة: | 0 (MET protein, human) 0 (ZIF-8 metal-organic framework) |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240508 Latest Revision: 20240517 |
| رمز التحديث: | 20240517 |
| DOI: | 10.1016/j.bios.2024.116319 |
| PMID: | 38669845 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4235 |
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| DOI: | 10.1016/j.bios.2024.116319 |