دورية أكاديمية
أعرض في EDS

Duplicate Gene Expression and Possible Mechanisms of Paralog Retention During Bacterial Genome Expansion.

التفاصيل البيبلوغرافية
العنوان: Duplicate Gene Expression and Possible Mechanisms of Paralog Retention During Bacterial Genome Expansion.
المؤلفون: Garber AI; Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA., Sano EB; Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA., Gallagher AL; Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA., Miller SR; Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
المصدر: Genome biology and evolution [Genome Biol Evol] 2024 May 02; Vol. 16 (5).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101509707 Publication Model: Print Cited Medium: Internet ISSN: 1759-6653 (Electronic) Linking ISSN: 17596653 NLM ISO Abbreviation: Genome Biol Evol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Oxford University Press
مواضيع طبية MeSH: Gene Duplication* , Genome, Bacterial* , Cyanobacteria*/genetics , Cyanobacteria*/metabolism , Evolution, Molecular*, Gene Dosage ; Gene Expression Regulation, Bacterial ; Genes, Duplicate
مستخلص: Gene duplication contributes to the evolution of expression and the origin of new genes, but the relative importance of different patterns of duplicate gene expression and mechanisms of retention remains debated and particularly poorly understood in bacteria. Here, we investigated gene expression patterns for two lab strains of the cyanobacterium Acaryochloris marina with expanding genomes that contain about 10-fold more gene duplicates compared with most bacteria. Strikingly, we observed a generally stoichiometric pattern of greater combined duplicate transcript dosage with increased gene copy number, in contrast to the prevalence of expression reduction reported for many eukaryotes. We conclude that increased transcript dosage is likely an important mechanism of initial duplicate retention in these bacteria and may persist over long periods of evolutionary time. However, we also observed that paralog expression can diverge rapidly, including possible functional partitioning, for which different copies were respectively more highly expressed in at least one condition. Divergence may be promoted by the physical separation of most Acaryochloris duplicates on different genetic elements. In addition, expression pattern for ancestrally shared duplicates could differ between strains, emphasizing that duplicate expression fate need not be deterministic. We further observed evidence for context-dependent transcript dosage, where the aggregate expression of duplicates was either greater or lower than their single-copy homolog depending on physiological state. Finally, we illustrate how these different expression patterns of duplicated genes impact Acaryochloris biology for the innovation of a novel light-harvesting apparatus and for the regulation of recA paralogs in response to environmental change.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
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معلومات مُعتمدة: United States NASA NASA
فهرسة مساهمة: Keywords: bacteria; gene duplication; neofunctionalization; positive dosage
تواريخ الأحداث: Date Created: 20240426 Date Completed: 20240510 Latest Revision: 20240703
رمز التحديث: 20240704
مُعرف محوري في PubMed: PMC11086944
DOI: 10.1093/gbe/evae089
PMID: 38670115
قاعدة البيانات: MEDLINE
الوصف
تدمد:1759-6653
DOI:10.1093/gbe/evae089