دورية أكاديمية
Development and therapeutic implications of small molecular inhibitors that target calcium-related channels in tumor treatment.
| العنوان: | Development and therapeutic implications of small molecular inhibitors that target calcium-related channels in tumor treatment. |
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| المؤلفون: | Zhang L; China Medical University-Queen's University of Belfast Joint College, China Medical University, Shenyang 110000, Liaoning, China., Ren C; Department of Pharmacy, Chengdu Fifth People's Hospital, Chengdu 611130, China., Liu J; Department of Pharmacy, Chengdu Fifth People's Hospital, Chengdu 611130, China., Huang S; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China. Electronic address: shuaih@swjtu.edu.cn., Wu C; Department of Neurology, Laboratory of Neuro-system and Multimorbidity and Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: allenwu1991@163.com., Zhang J; Department of Neurology, Laboratory of Neuro-system and Multimorbidity and Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: zjf298257@163.com. |
| المصدر: | Drug discovery today [Drug Discov Today] 2024 Jun; Vol. 29 (6), pp. 103995. Date of Electronic Publication: 2024 Apr 24. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford : Irvington, NJ : Elsevier Science Ltd. ; Distributed by Virgin Mailing and Distribution, c1996- |
| مواضيع طبية MeSH: | Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Calcium Channels*/metabolism , Epithelial-Mesenchymal Transition*/drug effects , Calcium Channel Blockers*/pharmacology , Calcium Channel Blockers*/therapeutic use, Humans ; Animals ; Drug Development/methods ; Drug Resistance, Neoplasm ; Calcium/metabolism |
| مستخلص: | Calcium ion dysregulation exerts profound effects on various physiological activities such as tumor proliferation, migration, and drug resistance. Calcium-related channels play a regulatory role in maintaining calcium ion homeostasis, with most channels being highly expressed in tumor cells. Additionally, these channels serve as potential drug targets for the development of antitumor medications. In this review, we first discuss the current research status of these pathways, examining how they modulate various tumor functions such as epithelial-mesenchymal transition (EMT), metabolism, and drug resistance. Simultaneously, we summarize the recent progress in the study of novel small-molecule drugs over the past 5 years and their current status. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: calcium-related channels; cancer; drug discovery; small-molecular inhibitor |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Calcium Channels) 0 (Calcium Channel Blockers) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240526 Latest Revision: 20240526 |
| رمز التحديث: | 20240527 |
| DOI: | 10.1016/j.drudis.2024.103995 |
| PMID: | 38670255 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5832 |
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| DOI: | 10.1016/j.drudis.2024.103995 |