دورية أكاديمية
Diagnostic efficacy and clinical impact of image-guided core needle biopsy of suspected vertebral osteomyelitis.
| العنوان: | Diagnostic efficacy and clinical impact of image-guided core needle biopsy of suspected vertebral osteomyelitis. |
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| المؤلفون: | Winkler WL; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA. Electronic address: winstonwinkler@wustl.edu., George IA; John T. Milliken Department of Internal Medicine, Division of Infectious Disease, St. Louis, USA., Gandra S; John T. Milliken Department of Internal Medicine, Division of Infectious Disease, St. Louis, USA., Baker JC; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA., Tomasian A; Department of Radiology, Section of Musculoskeletal Radiology, University of Southern California, Los Angeles, USA., Northrup B; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA., Velde TLV; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA., Hillen TJ; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA., Luo C; Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, USA., Imaoka R; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA., Dettorre GM; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA., Jennings JW; Department of Radiology, Section of Musculoskeletal Radiology, Mallinckrodt Institute of Radiology, St. Louis, USA. |
| المصدر: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Jul; Vol. 144, pp. 107027. Date of Electronic Publication: 2024 Apr 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| مواضيع طبية MeSH: | Osteomyelitis*/diagnosis , Osteomyelitis*/microbiology , Osteomyelitis*/pathology , Osteomyelitis*/drug therapy , Image-Guided Biopsy*/methods, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Biopsy, Large-Core Needle/methods ; Aged ; Adult ; Aged, 80 and over ; Spine/pathology ; Spine/diagnostic imaging ; Spine/microbiology ; Spinal Diseases/diagnosis ; Spinal Diseases/microbiology ; Spinal Diseases/pathology ; Spinal Diseases/drug therapy |
| مستخلص: | Objectives: The diagnostic yield and clinical impact of image-guided core needle biopsy (ICNB) of suspected vertebral osteomyelitis in adults is heterogenous in published studies owing to small sample sizes, indicating the need for large cohort studies. Methods: A retrospective analysis of ICNBs was performed from 2010 to 2021 for patients with imaging findings consistent with vertebral osteomyelitis. For each biopsy, a series of factors were analyzed, as well as if histopathology was diagnostic of osteomyelitis and if microbiological cultures were positive. In addition, it was recorded in what way biopsy influenced clinical management regarding antimicrobial treatment. A multivariate statistical analysis was performed to evaluate the factors associated with yield. Results: A total of 570 biopsies performed on 527 patients were included. A histopathologic diagnosis of osteomyelitis was made in 68.4% (359 of 525) of biopsies, and microbiological cultures were positive in 29.6% (169 of 570). Elevated erythrocyte sedimentation rate was positively associated with a histopathologic diagnosis of osteomyelitis (odds ratio [OR] =1.96, P = 0.007) and positive cultures from bone cores (OR = 1.02, P ≤0.001) and aspirate (OR = 1.02, P ≤0.001). Increased total core length was positively associated with a histopathologic diagnosis of osteomyelitis (OR = 1.81, P = 0.013) and positive cultures from bone cores (OR = 1.65, P = 0.049). Clinical management was affected by ICNB in 37.5% (214 of 570) of cases. Conclusions: In this large cohort, ICNB yielded approximately 30% positive cultures and changed clinical management in over one-third of the patients. Competing Interests: Declaration of competing interest The authors have no competing interests to declare. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bone biopsy; Diagnostic yield; Image-guided core needle biopsy; Vertebral osteomyelitis |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240530 Latest Revision: 20240530 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1016/j.ijid.2024.107027 |
| PMID: | 38670483 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-3511 |
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| DOI: | 10.1016/j.ijid.2024.107027 |