دورية أكاديمية
T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1α/AMPK signaling axis.
| العنوان: | T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1α/AMPK signaling axis. |
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| المؤلفون: | Qi F; Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China; National Healthy Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Heilongjiang Provincial Laboratory of Trace Element and Human Health, Harbin Medical University, Harbin, 150081, China., Cui SL; Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China; National Healthy Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Heilongjiang Provincial Laboratory of Trace Element and Human Health, Harbin Medical University, Harbin, 150081, China., Zhang B; Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China; National Healthy Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Heilongjiang Provincial Laboratory of Trace Element and Human Health, Harbin Medical University, Harbin, 150081, China; School of Public Health, Beihua University, Jilin, 132013, Jilin, China., Li HN; Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China; National Healthy Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Heilongjiang Provincial Laboratory of Trace Element and Human Health, Harbin Medical University, Harbin, 150081, China., Yu J; Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China; National Healthy Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Heilongjiang Provincial Laboratory of Trace Element and Human Health, Harbin Medical University, Harbin, 150081, China. Electronic address: 6yujun@126.com. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 May 28; Vol. 243, pp. 107735. Date of Electronic Publication: 2024 Apr 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | T-2 Toxin*/toxicity , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Cartilage, Articular*/drug effects , Cartilage, Articular*/pathology , Autophagy*/drug effects , Signal Transduction*/drug effects , AMP-Activated Protein Kinases*/metabolism , Rats, Sprague-Dawley*, Animals ; Male ; Rats |
| مستخلص: | T-2 toxin is one of the most toxic mycotoxins. People are primarily exposed to T-2 toxin through the consumption of spoiled food, typically over extended periods and at low doses. T-2 toxin can cause damage to articular cartilage. However, the exact mechanism is not fully understood. In this experiment, 36 male rats were divided into a control group, a solvent control group, and a T-2 toxin group. The rats in the T-2 toxin group were orally administered the toxin at a dosage of 100 ng/g BW/Day. The damage to articular cartilage and key proteins associated with the autophagy process and the HIF-1α/AMPK signaling axis was assessed at 4, 8, 12, and 16 weeks. Our findings indicate that T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1α/AMPK signaling pathway. This study offers novel insights into the precise mechanism underlying T-2 toxin-induced damage to articular cartilage. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Articular cartilage; Autophagy; Chronic; HIF-1α/AMPK; Rats; T-2 toxin |
| المشرفين على المادة: | 0 (Hif1a protein, rat) |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240517 Latest Revision: 20240517 |
| رمز التحديث: | 20240518 |
| DOI: | 10.1016/j.toxicon.2024.107735 |
| PMID: | 38670500 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2024.107735 |