دورية أكاديمية
أعرض في EDS

Adequate antiviral treatment lowers overall complications of cytomegalovirus colitis among inpatients with inflammatory bowel diseases.

التفاصيل البيبلوغرافية
العنوان: Adequate antiviral treatment lowers overall complications of cytomegalovirus colitis among inpatients with inflammatory bowel diseases.
المؤلفون: Hsieh CR; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan., Wu RC; Department of Anatomic Pathology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.; Chang Gung Inflammatory Bowel Disease Center, Taoyuan, Taiwan., Kuo CJ; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.; Taiwan Association of the Study of Small Intestinal Disease, Taoyuan, Taiwan.; Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan.; Chang Gung Inflammatory Bowel Disease Center, Taoyuan, Taiwan., Yeh PJ; Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan.; Division of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.; Chang Gung Inflammatory Bowel Disease Center, Taoyuan, Taiwan., Yeh YM; Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan.; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan., Chen CL; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan., Chiu CT; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.; Taiwan Association of the Study of Small Intestinal Disease, Taoyuan, Taiwan.; Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan.; Chang Gung Inflammatory Bowel Disease Center, Taoyuan, Taiwan., Chiu CH; Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan.; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan., Pan YB; Biostatistical Section, Clinical Trial Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan., Tsou YK; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan., Le PH; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. puohsien@gmail.com.; Taiwan Association of the Study of Small Intestinal Disease, Taoyuan, Taiwan. puohsien@gmail.com.; Chang Gung Microbiota Therapy Center, Taoyuan, Taiwan. puohsien@gmail.com.; Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. puohsien@gmail.com.; Chang Gung Inflammatory Bowel Disease Center, Taoyuan, Taiwan. puohsien@gmail.com.
المصدر: BMC infectious diseases [BMC Infect Dis] 2024 Apr 26; Vol. 24 (1), pp. 443. Date of Electronic Publication: 2024 Apr 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Cytomegalovirus Infections*/drug therapy , Cytomegalovirus Infections*/complications , Cytomegalovirus Infections*/virology , Antiviral Agents*/therapeutic use , Inflammatory Bowel Diseases*/drug therapy , Inflammatory Bowel Diseases*/complications , Colitis*/virology , Colitis*/drug therapy , Colitis*/complications, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Cytomegalovirus/drug effects ; Risk Factors ; Aged ; Inpatients ; Treatment Outcome
مستخلص: Background: Cytomegalovirus (CMV) colitis significantly complicates the course of inflammatory bowel disease (IBD), frequently leading to severe flare-ups and poor outcomes. The role of antiviral therapy in hospitalized IBD patients with CMV colitis is currently under debate. This retrospective analysis seeks to clarify the influence of antiviral treatment on these patients.
Methods: We retrospectively reviewed IBD patients diagnosed with CMV colitis via immunohistochemistry staining from colonic biopsies at a major tertiary center from January 2000 to May 2021. The study focused on patient demographics, clinical features, risk factors, prognostic indicators, and antiviral treatment outcomes.
Results: Among 118 inpatients, 42 had CMV colitis. Risk factors included hypoalbuminemia and antibiotic use. IBD patients with CMV colitis receiving < 14 days of antiviral therapy had higher complication (72% vs. 43%, p = 0.028) and surgery rates (56% vs. 26%, p = 0.017) compared to those without CMV. Adequate antiviral therapy (≥ 14 days) significantly reduced complications in the CMV group (29% vs. 72%, p = 0.006), especially in Crohn's disease (20% vs. 100%, p = 0.015). Independent predictors of IBD-related complications were CMV colitis (Odds Ratio [OR] 3.532, 90% Confidence Interval [CI] 1.012-12.331, p = 0.048), biological treatment failure (OR 4.953, 95% CI 1.91-12.842, p = 0.001), and adequate antiviral therapy (OR 0.108, 95% CI 0.023-0.512, p = 0.005).
Conclusion: CMV colitis and a history of biological treatment failure increase complication risks in IBD patients. Adequate antiviral therapy significantly mitigates these risks, highlighting its importance in managing IBD patients with CMV colitis.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Antiviral treatment; Complication; Cytomegalovirus; Inflammatory bowel disease; Risk factor
المشرفين على المادة: 0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20240426 Date Completed: 20240427 Latest Revision: 20240429
رمز التحديث: 20240429
مُعرف محوري في PubMed: PMC11046852
DOI: 10.1186/s12879-024-09317-w
PMID: 38671346
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-024-09317-w