دورية أكاديمية
Understanding Tendon Fibroblast Biology and Heterogeneity.
| العنوان: | Understanding Tendon Fibroblast Biology and Heterogeneity. |
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| المؤلفون: | DiIorio SE; Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Young B; Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Parker JB; Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Griffin MF; Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Longaker MT; Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. |
| المصدر: | Biomedicines [Biomedicines] 2024 Apr 12; Vol. 12 (4). Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
| مستخلص: | Tendon regeneration has emerged as an area of interest due to the challenging healing process of avascular tendon tissue. During tendon healing after injury, the formation of a fibrous scar can limit tendon strength and lead to subsequent complications. The specific biological mechanisms that cause fibrosis across different cellular subtypes within the tendon and across different tendons in the body continue to remain unknown. Herein, we review the current understanding of tendon healing, fibrosis mechanisms, and future directions for treatments. We summarize recent research on the role of fibroblasts throughout tendon healing and describe the functional and cellular heterogeneity of fibroblasts and tendons. The review notes gaps in tendon fibrosis research, with a focus on characterizing distinct fibroblast subpopulations in the tendon. We highlight new techniques in the field that can be used to enhance our understanding of complex tendon pathologies such as fibrosis. Finally, we explore bioengineering tools for tendon regeneration and discuss future areas for innovation. Exploring the heterogeneity of tendon fibroblasts on the cellular level can inform therapeutic strategies for addressing tendon fibrosis and ultimately reduce its clinical burden. |
| References: | Front Pharmacol. 2020 Jan 28;10:1649. (PMID: 32063855) Bioeng Transl Med. 2022 Jun 03;8(1):e10345. (PMID: 36684098) Injury. 2023 Nov;54(11):111052. (PMID: 37738787) Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4219-23. (PMID: 8633044) Science. 2015 Apr 17;348(6232):aaa2151. (PMID: 25883361) Tissue Eng Part C Methods. 2015 Mar;21(3):314-21. (PMID: 25275778) Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C389-C403. (PMID: 29341790) Plast Reconstr Surg. 2019 Oct;144(4):639e-647e. (PMID: 31568303) Biomaterials. 2015 Aug;61:61-74. (PMID: 25996412) Acta Biomater. 2021 Apr 1;124:15-32. (PMID: 33508510) Int J Mol Sci. 2020 Sep 14;21(18):. (PMID: 32937830) J Orthop Res. 2015 Jun;33(6):793-9. (PMID: 25640030) Knee Surg Sports Traumatol Arthrosc. 2015 Jul;23(7):2097-105. (PMID: 24057354) Knee Surg Sports Traumatol Arthrosc. 2008 Sep;16(9):834-42. (PMID: 18516592) Nat Rev Immunol. 2023 Oct;23(10):613. (PMID: 37653335) Am J Sports Med. 2011 Nov;39(11):2476-83. (PMID: 21515806) J Clin Invest. 2008 Feb;118(2):439-44. (PMID: 18246194) J Mech Behav Biomed Mater. 2015 Dec;52:85-94. (PMID: 25958330) Br J Sports Med. 1999 Apr;33(2):129-30. (PMID: 10205697) J Orthop Sports Phys Ther. 2015 Nov;45(11):829-32. (PMID: 27136289) J Orthop Surg Res. 2021 Dec 4;16(1):700. (PMID: 34863223) Sci Rep. 2020 Sep 3;10(1):13939. (PMID: 32883960) Development. 2021 Apr 15;148(8):. (PMID: 33913478) Biomed Mater. 2019 Jun 19;14(4):044102. (PMID: 31108473) J Physiol. 2023 Sep;601(17):3869-3884. (PMID: 37493407) Biomedicines. 2023 Aug 14;11(8):. (PMID: 37626760) Hand (N Y). 2015 Sep;10(3):482-8. (PMID: 26330782) Science. 2021 Apr 23;372(6540):. (PMID: 33888614) Elife. 2021 Jan 22;10:. (PMID: 33480357) Acta Orthop Scand. 1981 Dec;52(6):615-22. (PMID: 7331798) BMC Musculoskelet Disord. 2009 Feb 26;10:27. (PMID: 19245707) Nat Cell Biol. 2019 Dec;21(12):1490-1503. (PMID: 31768046) Front Bioeng Biotechnol. 2023 Sep 14;11:1250533. (PMID: 37781529) Orthopedics. 2010 Mar;33(3):164-70. (PMID: 20349872) Sports Med. 2003;33(5):381-94. (PMID: 12696985) Tissue Eng Regen Med. 2021 Feb;18(1):1-14. (PMID: 33150560) Acta Orthop Scand. 1999 Feb;70(1):51-4. (PMID: 10191749) Scand J Med Sci Sports. 2000 Dec;10(6):312-20. (PMID: 11085557) PLoS One. 2018 Oct 16;13(10):e0205811. (PMID: 30325952) J Musculoskelet Neuronal Interact. 2010 Mar;10(1):35-45. (PMID: 20190378) Sci Rep. 2017 Aug 17;7(1):8658. (PMID: 28819185) Nat Biomed Eng. 2022 Oct;6(10):1167-1179. (PMID: 34980903) Am J Physiol Cell Physiol. 2020 Nov 1;319(5):C885-C894. (PMID: 32877217) Front Immunol. 2023 Feb 28;14:1137659. (PMID: 36926329) Front Immunol. 2023 May 08;14:1092778. (PMID: 37223090) J Orthop Res. 2010 May;28(5):639-43. (PMID: 19918904) Acta Biomater. 2013 Jun;9(6):6905-14. (PMID: 23416576) Cell Rep. 2022 Nov 22;41(8):111706. (PMID: 36417854) Front Genet. 2019 Apr 05;10:317. (PMID: 31024627) J Orthop Res. 2015 Jun;33(6):780-4. (PMID: 25764524) J R Soc Interface. 2012 Nov 7;9(76):3108-17. (PMID: 22764132) Biomolecules. 2022 Oct 20;12(10):. (PMID: 36291727) Front Bioeng Biotechnol. 2023 Feb 20;11:1115312. (PMID: 36890920) Elife. 2023 Jan 19;12:. (PMID: 36656751) Matrix Biol. 2013 Mar 11;32(2):106-16. (PMID: 23357642) Cell Rep Med. 2021 Jul 21;2(7):100343. (PMID: 34337559) J Hand Surg Eur Vol. 2013 Jul;38(6):651-7. (PMID: 22918883) Arthritis Res Ther. 2009;11(3):235. (PMID: 19591655) J Orthop Res. 2001 Nov;19(6):1203-9. (PMID: 11781025) J Orthop Res. 2015 Jun;33(6):832-9. (PMID: 25641114) Int J Mol Sci. 2023 Jan 25;24(3):. (PMID: 36768692) Front Physiol. 2022 Jun 13;13:852795. (PMID: 35770188) Cell Stem Cell. 2022 Aug 4;29(8):1161-1180. (PMID: 35931028) Arthroscopy. 1998 Nov-Dec;14(8):840-3. (PMID: 9848596) Nat Commun. 2020 Aug 7;11(1):3953. (PMID: 32769974) Sci Rep. 2017 Aug 30;7(1):9713. (PMID: 28855560) J Orthop Res. 2023 Oct;41(10):2082-2092. (PMID: 37211925) Nat Commun. 2022 Jun 14;13(1):3409. (PMID: 35701396) Am J Pathol. 2009 Nov;175(5):1938-51. (PMID: 19834058) Transl Res. 2019 Jul;209:156-168. (PMID: 30776336) J Orthop Res. 2020 Jan;38(1):7-12. (PMID: 31529731) FASEB J. 2020 Mar;34(3):3677-3692. (PMID: 31930613) Front Bioeng Biotechnol. 2020 Feb 25;8:130. (PMID: 32158751) Bioeng Transl Med. 2022 Jul 14;8(1):e10355. (PMID: 36684085) Adv Drug Deliv Rev. 2015 Apr;84:257-77. (PMID: 25499820) J Physiol. 2020 Apr;598(8):1537-1550. (PMID: 32083717) J Hand Surg Br. 1984 Jun;9(2):117-20. (PMID: 6431041) Ann Plast Surg. 2004 Dec;53(6):560-4. (PMID: 15602253) Curr Sports Med Rep. 2006 Sep;5(5):233-41. (PMID: 16934204) J Anat. 2008 Mar;212(3):211-28. (PMID: 18304204) Theranostics. 2021 Apr 3;11(12):5911-5925. (PMID: 33897889) Knee Surg Sports Traumatol Arthrosc. 2022 Mar;30(3):1109-1117. (PMID: 34657973) J Invest Dermatol. 2012 Nov;132(11):2565-72. (PMID: 22696053) Am J Sports Med. 2012 Sep;40(9):1993-2001. (PMID: 22896627) Connect Tissue Res. 2018 Sep;59(5):423-436. (PMID: 29447021) |
| فهرسة مساهمة: | Keywords: biomaterials; fibroblast; fibrosis; tendon; tenocyte |
| تواريخ الأحداث: | Date Created: 20240427 Latest Revision: 20240429 |
| رمز التحديث: | 20240429 |
| مُعرف محوري في PubMed: | PMC11048404 |
| DOI: | 10.3390/biomedicines12040859 |
| PMID: | 38672213 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2227-9059 |
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| DOI: | 10.3390/biomedicines12040859 |