دورية أكاديمية
Fetal Alcohol Spectrum Disorder: The Honey Bee as a Social Animal Model.
العنوان: | Fetal Alcohol Spectrum Disorder: The Honey Bee as a Social Animal Model. |
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المؤلفون: | Camilli MP; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Simko OM; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Bevelander B; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Thebeau JM; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Masood F; Department of Veterinary Microbiology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., da Silva MCB; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Raza MF; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Markova S; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Obshta O; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Jose MS; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Biganski S; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Kozii IV; Prairie Diagnostic Services Inc., Saskatoon, SK S7N 5B4, Canada., Zabrodski MW; Prairie Diagnostic Services Inc., Saskatoon, SK S7N 5B4, Canada., Moshynskyy I; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Simko E; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada., Wood SC; Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, SK S7N 5B4, Canada. |
المصدر: | Life (Basel, Switzerland) [Life (Basel)] 2024 Mar 25; Vol. 14 (4). Date of Electronic Publication: 2024 Mar 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2011- |
مستخلص: | Animal models have been essential for advancing research of fetal alcohol spectrum disorder (FASD) in humans, but few animal species effectively replicate the behavioural and clinical signs of FASD. The honey bee ( Apis mellifera ) is a previously unexplored research model for FASD that offers the distinct benefit of highly social behaviour. In this study, we chronically exposed honey bee larvae to incremental concentrations of 0, 3, 6, and 10% ethanol in the larval diet using an in vitro rearing protocol and measured developmental time and survival to adult eclosion, as well as body weight and motor activity of newly emerged adult bees. Larvae reared on 6 and 10% dietary ethanol demonstrated significant, dose-responsive delays to pupation and decreased survival and adult body weight. All ethanol-reared adults showed significantly decreased motor activity. These results suggest that honey bees may be a suitable social animal model for future FASD research. |
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معلومات مُعتمدة: | This study was supported by start-up research funding provided by Mitacs Accelerate the University of Saskatchewan, Western College of Veterinary Medicine Mitacs |
فهرسة مساهمة: | Keywords: animal models of human disease; fetal alcohol spectrum disorder; honey bee |
تواريخ الأحداث: | Date Created: 20240427 Latest Revision: 20240429 |
رمز التحديث: | 20240429 |
مُعرف محوري في PubMed: | PMC11051024 |
DOI: | 10.3390/life14040434 |
PMID: | 38672706 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2075-1729 |
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DOI: | 10.3390/life14040434 |