Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner.

التفاصيل البيبلوغرافية
العنوان:	Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner.
المؤلفون:	Schavinski AZ; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Reis NG; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Morgan HJN; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Assis AP; Department of Biochemistry/Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Moro ML; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Valentim RR; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Seni-Silva AC; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Ramos ES; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Kettelhut IC; Department of Biochemistry/Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil., Navegantes LCC; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
المصدر:	International journal of molecular sciences [Int J Mol Sci] 2024 Apr 09; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 09.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH:	Insulin-Secreting Cells/metabolism , Vitamin D Deficiency/metabolism , Rats, Wistar* , Insulin/blood , Insulin/metabolism, Animals ; Female ; Male ; Rats ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism ; Prenatal Exposure Delayed Effects/etiology ; Sex Factors ; Insulin Secretion
مستخلص:	Recent studies have shown that maternal vitamin D deficiency (VDD) causes long-term metabolic changes in offspring. However, little is known about the impact of maternal VDD on offspring endocrine pancreas development and insulin secretion in the adult life of male and female animals. Female rats (Wistar Hannover) were fed either control (1000 IU Vitamin D3/kg), VDD (0 IU Vitamin D3/kg), or a Ca ²⁺ -enriched VDD diet (0 IU Vitamin D3/kg + Ca ²⁺ and P/kg) for 6 weeks and during gestation and lactation. At weaning, VDD status was confirmed based on low serum calcidiol levels in dams and pups. Next, male and female offspring were randomly separated and fed a standard diet for up to 90 days. At this age, serum calcidiol levels were restored to normal levels in all groups, but serum insulin levels were decreased in VDD males without affecting glucagon levels, glycemia, or glucose tolerance. Islets isolated from VDD males showed lower insulin secretion in response to different glucose concentrations, but this effect was not observed in VDD females. Furthermore, VDD males, but not females, showed a smaller total pancreatic islet area and lower β cell mass, an effect that was accompanied by reduced gene expression of Ins1 , Ins2 , Pdx1 , and SLC2A2 . The decrease in Pdx1 expression was not related to the methylation profile of the promoter region of this gene. Most of these effects were observed in the male VDD+Ca ²⁺ group, indicating that the effects were not due to alterations in Ca ²⁺ metabolism. These data show that maternal VDD selectively impairs the morphology and function of β cells in adult male offspring rats and that female offspring are fully protected from these deleterious effects.
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معلومات مُعتمدة:	2018/10089-2 Fundação de Amparo à Pesquisa do Estado de São Paulo; 302396/2022-5 National Council for Scientific and Technological Development; PROEX Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة:	Keywords: fetal programming; sexual dimorphism; vitamin D; β cell function
المشرفين على المادة:	0 (Insulin)
تواريخ الأحداث:	Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240429
رمز التحديث:	20240429
مُعرف محوري في PubMed:	PMC11050228
DOI:	10.3390/ijms25084136
PMID:	38673723
قاعدة البيانات:	MEDLINE

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تدمد:	1422-0067
DOI:	10.3390/ijms25084136