دورية أكاديمية
أعرض في EDS

The CaMK Family Differentially Promotes Necroptosis and Mouse Cardiac Graft Injury and Rejection.

التفاصيل البيبلوغرافية
العنوان: The CaMK Family Differentially Promotes Necroptosis and Mouse Cardiac Graft Injury and Rejection.
المؤلفون: Lu H; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Department of Pathology, Western University, London, ON N6A 3K7, Canada., Jiang J; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada., Min J; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada., Huang X; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada., McLeod P; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada., Liu W; Department of Pathology, Western University, London, ON N6A 3K7, Canada., Haig A; Department of Pathology, Western University, London, ON N6A 3K7, Canada., Gunaratnam L; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada.; Multi-Organ Transplant Program, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Division of Nephrology, Department of Medicine, Western University, London, ON N6A 3K7, Canada., Jevnikar AM; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada.; Multi-Organ Transplant Program, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Division of Nephrology, Department of Medicine, Western University, London, ON N6A 3K7, Canada., Zhang ZX; Matthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Department of Pathology, Western University, London, ON N6A 3K7, Canada.; Multi-Organ Transplant Program, London Health Sciences Centre, London, ON N6A 5A5, Canada.; Division of Nephrology, Department of Medicine, Western University, London, ON N6A 3K7, Canada.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 17; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Necroptosis* , Graft Rejection*/metabolism , Graft Rejection*/pathology , Heart Transplantation*/adverse effects , Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism , Receptor-Interacting Protein Serine-Threonine Kinases*/genetics , Dynamins*/metabolism , Dynamins*/genetics, Animals ; Mice ; Mitochondria/metabolism ; Endothelial Cells/metabolism ; Male ; Mice, Inbred C57BL ; Phosphoprotein Phosphatases/metabolism ; Phosphoprotein Phosphatases/genetics ; Phosphorylation ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Signal Transduction
مستخلص: Organ transplantation is associated with various forms of programmed cell death which can accelerate transplant injury and rejection. Targeting cell death in donor organs may represent a novel strategy for preventing allograft injury. We have previously demonstrated that necroptosis plays a key role in promoting transplant injury. Recently, we have found that mitochondria function is linked to necroptosis. However, it remains unknown how necroptosis signaling pathways regulate mitochondrial function during necroptosis. In this study, we investigated the receptor-interacting protein kinase 3 (RIPK3) mediated mitochondrial dysfunction and necroptosis. We demonstrate that the calmodulin-dependent protein kinase (CaMK) family members CaMK1, 2, and 4 form a complex with RIPK3 in mouse cardiac endothelial cells, to promote trans-phosphorylation during necroptosis. CaMK1 and 4 directly activated the dynamin-related protein-1 (Drp1), while CaMK2 indirectly activated Drp1 via the phosphoglycerate mutase 5 (PGAM5). The inhibition of CaMKs restored mitochondrial function and effectively prevented endothelial cell death. CaMKs inhibition inhibited activation of CaMKs and Drp1, and cell death and heart tissue injury (n = 6/group, p < 0.01) in a murine model of cardiac transplantation. Importantly, the inhibition of CaMKs greatly prolonged heart graft survival (n = 8/group, p < 0.01). In conclusion, CaMK family members orchestrate cell death in two different pathways and may be potential therapeutic targets in preventing cell death and transplant injury.
References: Dev Cell. 2001 Oct;1(4):515-25. (PMID: 11703942)
Circ Res. 2013 Mar 15;112(6):935-44. (PMID: 23388157)
J Biol Chem. 1996 Mar 8;271(10):5617-22. (PMID: 8621423)
J Mol Cell Cardiol. 2023 Nov;184:48-60. (PMID: 37813179)
Transplantation. 2017 Sep;101(9):2026-2037. (PMID: 29633982)
Biochim Biophys Acta. 2011 Apr;1813(4):616-22. (PMID: 20888866)
Cell Death Dis. 2014 Feb 27;5:e1086. (PMID: 24577084)
Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47. (PMID: 15040446)
Science. 1996 Dec 6;274(5293):1678-83. (PMID: 8939850)
J Neurochem. 2017 Jun;141(6):808-818. (PMID: 28295333)
Biochem Biophys Res Commun. 2018 Jan 8;495(2):1601-1607. (PMID: 29217195)
Nat Rev Mol Cell Biol. 2017 Feb;18(2):127-136. (PMID: 27999438)
J Biol Chem. 2007 Apr 6;282(14):10833-9. (PMID: 17296607)
Cell Rep. 2013 Nov 27;5(4):878-85. (PMID: 24268776)
Cell Calcium. 2020 Dec;92:102286. (PMID: 32932146)
Annu Rev Immunol. 2015;33:79-106. (PMID: 25493335)
J Immunol. 2016 Jan 1;196(1):407-15. (PMID: 26582950)
Am J Transplant. 2019 Mar;19(3):686-698. (PMID: 30203531)
Biochem Biophys Res Commun. 2022 Dec 25;636(Pt 2):104-112. (PMID: 36368152)
Nature. 2018 Jun;558(7710):401-405. (PMID: 29899447)
Nature. 2015 Jan 15;517(7534):311-20. (PMID: 25592536)
Am J Transplant. 2014 Aug;14(8):1778-90. (PMID: 24984764)
Mol Biol Cell. 2001 Aug;12(8):2245-56. (PMID: 11514614)
EMBO J. 1995 Aug 1;14(15):3679-86. (PMID: 7641687)
Cell Mol Life Sci. 2016 Jun;73(11-12):2309-24. (PMID: 27048819)
Int J Mol Med. 2023 Oct;52(4):. (PMID: 37654208)
J Biol Chem. 2004 Sep 24;279(39):40296-302. (PMID: 15262966)
Front Physiol. 2014 Aug 26;5:323. (PMID: 25206339)
Nat Med. 2016 Feb;22(2):175-82. (PMID: 26726877)
Nat Rev Immunol. 2014 Nov;14(11):759-67. (PMID: 25324125)
Cell Calcium. 2011 Jul;50(1):1-8. (PMID: 21529938)
Nature. 2012 Nov 8;491(7423):269-73. (PMID: 23051746)
Int J Mol Sci. 2021 Oct 13;22(20):. (PMID: 34681708)
Nat Commun. 2016 Oct 14;7:13189. (PMID: 27739424)
Bull Exp Biol Med. 2021 Jul;171(3):297-304. (PMID: 34302204)
Cell Death Dis. 2014 Jan 16;5:e1004. (PMID: 24434512)
Cardiovasc Res. 2007 Mar 1;73(4):689-98. (PMID: 17217936)
Transplantation. 2006 May 27;81(10):1442-50. (PMID: 16732183)
Front Pharmacol. 2014 Feb 11;5:15. (PMID: 24575042)
J Cell Biol. 2008 Aug 11;182(3):573-85. (PMID: 18695047)
J Biol Chem. 1996 Aug 30;271(35):21542-8. (PMID: 8702940)
Am J Transplant. 2021 Oct;21(10):3268-3279. (PMID: 33784431)
Am J Transplant. 2022 Feb;22(2):386-401. (PMID: 34714588)
Cell. 2012 Jan 20;148(1-2):228-43. (PMID: 22265414)
معلومات مُعتمدة: FRN169045 Canada CAPMC CIHR
فهرسة مساهمة: Keywords: CaMK; Drp1; PGAM5; heart; necroptosis; transplantation
المشرفين على المادة: EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
EC 2.7.11.1 (Ripk3 protein, mouse)
EC 3.6.5.5 (Dynamins)
EC 3.6.5.5 (Dnm1l protein, mouse)
EC 3.1.3.16 (PGAM5 protein, mouse)
EC 3.1.3.16 (Phosphoprotein Phosphatases)
EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
تواريخ الأحداث: Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240429
رمز التحديث: 20240429
مُعرف محوري في PubMed: PMC11050252
DOI: 10.3390/ijms25084428
PMID: 38674016
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25084428