دورية أكاديمية
أعرض في EDS

APOE ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin.

التفاصيل البيبلوغرافية
العنوان: APOE ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin.
المؤلفون: Kondkar AA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia.; Glaucoma Research Chair in Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia.; King Saud University Medical City, King Saud University, Riyadh 11411, Saudi Arabia., Azad TA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia., Sultan T; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia., Khatlani T; Department of Blood and Cancer Research, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University of Health Sciences, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia., Alshehri AA; Department of Ophthalmology, Imam Abdulrahman Alfaisal Hospital, Riyadh 14723, Saudi Arabia., Radhakrishnan R; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55347, USA., Lobo GP; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55347, USA., Alsirhy E; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia., Almobarak FA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia., Osman EA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia., Al-Obeidan SA; Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia.; Glaucoma Research Chair in Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 22; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Apolipoprotein E2*/genetics , Genetic Predisposition to Disease* , Glaucoma, Angle-Closure*/genetics , Polymorphism, Single Nucleotide*, Female ; Humans ; Male ; Alleles ; Case-Control Studies ; Gene Frequency ; Genotype ; Haplotypes ; Heterozygote ; Risk Factors ; Saudi Arabia/epidemiology
مستخلص: This study investigated the association between apolipoprotein E ( APOE ) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 controls, 92 PACG, 94 PXG) was conducted using PCR-based Sanger sequencing. The results showed no significant differences in the allele and genotype frequencies of rs429358 and rs7412 between the PACG/PXG cases and controls. Haplotype analysis revealed ε3 as predominant, followed by ε4 and ε2 alleles, with no significant variance in PACG/PXG. However, APOE genotype analysis indicated a significant association between ε2-carriers and PACG (odds ratio = 4.82, 95% CI 1.52-15.26, p = 0.007), whereas no notable association was observed with PXG. Logistic regression confirmed ε2-carriers as a significant predictor for PACG ( p = 0.008), while age emerged as significant for PXG ( p < 0.001). These findings suggest a potential role of ε2-carriers in PACG risk within the Saudi cohort. Further validation and larger-scale investigations are essential to elucidate the precise role of APOE in PACG pathogenesis and progression.
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معلومات مُعتمدة: GRC-2024 King Saud University through the Vice Deanship of Scientific Research Chair and Glaucoma Research Chair in Ophthalmology
فهرسة مساهمة: Keywords: Saudi; angle-closure; apolipoprotein E; genetics; glaucoma; polymorphisms; pseudoexfoliation; rs429358; rs7412
المشرفين على المادة: 0 (Apolipoprotein E2)
تواريخ الأحداث: Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240522
رمز التحديث: 20240523
مُعرف محوري في PubMed: PMC11050284
DOI: 10.3390/ijms25084571
PMID: 38674156
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25084571