دورية أكاديمية
أعرض في EDS

Investigating the Influence of ANTXR2 Gene Mutations on Protective Antigen Binding for Heightened Anthrax Resistance.

التفاصيل البيبلوغرافية
العنوان: Investigating the Influence of ANTXR2 Gene Mutations on Protective Antigen Binding for Heightened Anthrax Resistance.
المؤلفون: Archana CA; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India., Sekar YS; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India., Suresh KP; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India., Subramaniam S; ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar 752050, India., Sagar N; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India., Rani S; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India., Anandakumar J; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India., Pandey RK; Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Solna, Sweden., Barman NN; College of Veterinary Science, Assam Agricultural University (AAU), Guwahati 781022, India., Patil SS; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru 560064, India.
المصدر: Genes [Genes (Basel)] 2024 Mar 28; Vol. 15 (4). Date of Electronic Publication: 2024 Mar 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Antigens, Bacterial*/genetics , Antigens, Bacterial*/immunology , Anthrax*/microbiology , Anthrax*/genetics , Anthrax*/immunology , Receptors, Peptide*/genetics , Mutation* , Polymorphism, Single Nucleotide*, Humans ; Bacterial Toxins/genetics ; Bacillus anthracis/genetics ; Bacillus anthracis/pathogenicity ; Hyaline Fibromatosis Syndrome/genetics ; Hyaline Fibromatosis Syndrome/microbiology ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/immunology ; Spondylitis, Ankylosing/microbiology ; Disease Resistance/genetics ; Receptors, Cell Surface/genetics ; Protein Binding
مستخلص: Bacillus anthracis is the bacterium responsible for causing the zoonotic disease called anthrax. The disease presents itself in different forms like gastrointestinal, inhalation, and cutaneous. Bacterial spores are tremendously adaptable, can persist for extended periods and occasionally endanger human health. The Anthrax Toxin Receptor-2 ( ANTXR2 ) gene acts as membrane receptor and facilitates the entry of the anthrax toxin into host cells. Additionally, mutations in the ANTXR2 gene have been linked to various autoimmune diseases, including Hyaline Fibromatosis Syndrome (HFS), Ankylosing Spondylitis (AS), Juvenile Hyaline Fibromatosis (JHF), and Infantile Systemic Hyalinosis (ISH). This study delves into the genetic landscape of ANTXR2 , aiming to comprehend its associations with diverse disorders, elucidate the impacts of its mutations, and pinpoint minimal non-pathogenic mutations capable of reducing the binding affinity of the ANTXR2 gene with the protective antigen. Recognizing the pivotal role of single-nucleotide polymorphisms (SNPs) in shaping genetic diversity, we conducted computational analyses to discern highly deleterious and tolerated non-synonymous SNPs (nsSNPs) in the ANTXR2 gene. The Mutpred2 server determined that the Arg465Trp alteration in the ANTXR2 gene leads to altered DNA binding ( p = 0.22) with a probability of a deleterious mutation of 0.808; notably, among the identified deleterious SNPs, rs368288611 (Arg465Trp) stands out due to its significant impact on altering the DNA-binding ability of ANTXR2 . We propose these SNPs as potential candidates for hypertension linked to the ANTXR2 gene, which is implicated in blood pressure regulation. Noteworthy among the tolerated substitutions is rs200536829 (Ala33Ser), recognized as less pathogenic; this highlights its potential as a valuable biomarker, potentially reducing side effects on the host while also reducing binding with the protective antigen protein. Investigating these SNPs holds the potential to correlate with several autoimmune disorders and mitigate the impact of anthrax disease in humans.
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معلومات مُعتمدة: 47013240002 The Pennsylvania State University,
فهرسة مساهمة: Keywords: ANTXR2; anthrax; molecular docking; protective antigen; single-nucleotide polymorphisms (SNPs)
المشرفين على المادة: 0 (ANTXR2 protein, human)
0 (Antigens, Bacterial)
0 (anthrax toxin)
0 (Receptors, Peptide)
0 (Bacterial Toxins)
0 (Receptors, Cell Surface)
تواريخ الأحداث: Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240612
رمز التحديث: 20240612
مُعرف محوري في PubMed: PMC11049084
DOI: 10.3390/genes15040426
PMID: 38674361
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes15040426